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PET imaging in stroke

PET imaging in stroke

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中国神经科学学会第十届全国学术会议

作者： Wolf-Dieter Heiss Max Planck Institute for Neurologigal Research

Cerebrovascular diseases are caused by interruption or significant impairment of blood supply to the brain,which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological *** pathophysiological changes can be assessed by positron emission tomography（PET）,which permits to measure regionally various physiologic parameters and to image the distribution of molecular *** has broadened our understanding of flow and metabolic thresholds critical for maintenance of brain function and morphology:in this apphcation PET was essential in the transfer of the concept of the penumbra,*** with perfusion below the functional threshold,but above the threshold for preservation of morphology,to clinical stroke and thereby had a great impact on developing treatment *** for receptors can be applied as early markers of irreversible neuronal damage and thereby can predict the size of the final infarcts,which is also important for decisions of invasive therapy in large（ "malignant"） *** PET investigations the reserve capacity of blood supply to the brain can be tested in obstructive arteriosclerosis of supplying arteries,which again is essential for planning *** effect of a stroke on surrounding and contralateral primarily not-affected tissue can be investigated,and these results help to understand symptoms caused by disturbance in functional *** cerebrovascular disease causes vascular cognitive disorders including vascular dementia which *** increasing burden of the aging *** allows imaging the localized and / or diffuse metabolic disturbances responsible for cognitive impairment and dementia,and is effective in differentiatmg vascular dementia from degenerative dementia,as Alzheimer’s *** also may help to understand the importance of inflammatory changes and their interaction with amyloid depositions for the development of pos

关键词： Ischemic stroke penumbra,irreversible neuronal damage cerebral blood flow oxygen consumption glucose metabolism benzodiazepine receptor malignant infarction poststroke dementia vascular cognitive impairment

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