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Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea

Asian Journal of Andrology 2020年第5期22卷 485-492页

作者： Tao Li Fu-Dong Fu Chang-Jing Wu Feng Qin Run Wang Jiu-Hong Yuan Andrology Laboratory West China HospitalSichuan UniversityChengdu 610041China Departm ent of Urology West China HospitalSichuan UniversityChengdu 610041China Department of Urology University of Texas M.D.Anderson Cancer CenterHoustonTX 77030USA

This study aimed to explore whether and how anti-lysyl oxidase(anti-LOX)combined with a vacuum device(VD)could promote penile lengthening and to evaluate the effect on erectile *** study was performed on four groups of adult rats:control,anti-LOX,VD(negative pressure value of-300 mmHg),and anti-LOX+*** length was measured by a modified VD method and verified on exposed length *** pressure(ICP)and maximum ICP/mean arterial pressure(MAP)ratio were recorded to assess erectile *** corpus cavernosum,LOX activity and concentrations of pyridinoline,desmosine,hydroxyproline,and elastin were analyzed;transmission electron microscope and Hart’s elastin staining were performed to monitor microstructural ***-LOX and VD significantly lengthened the penis by 10.8%(3.75 mm)and 8.2%(2.48 mm)compared with the control group,respectively,while anti-LOX+VD achieved the longest penile size(40.58±0.40 mm)which was 17.4%longer than the control group(34.58±0.54 mm).After 1-week washout,no penile retraction was ***,exposed penile length data confirmed that the penis in the anti-LOX+VD group was also significantly ***-LOX inhibited LOX activity to reduce pyridinoline level,which led the penile tunica albuginea ***,it had no effect on hydroxyproline,desmosine,and elastin ***,anti-LOX had no impact on erectile function,which was determined by ICP and ICP/MAP *** results suggest that anti-LOX elongates the penis by reducing pyridinoline,which induces tunica albuginea *** lengthening effect was more obvious when combined with a *** procedures had no impact on erectile function.

关键词： anti-lysyl oxidase crosslinking penile lengthening tunica albuginea remodeling vacuum device

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