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Cell-type-specific genes associated with cortical structural abnormalities in pediatric bipolar disorder

Psychoradiology 2022年第2期2卷 56-65页

作者： Wenkun Lei Qian Xiao Chun Wang Weijia Gao Yiwen Xiao Yingliang Dai Guangming Lu Linyan Su Yuan Zhong School of Psychology Nanjing Normal UniversityNanjingJiangsu 210097China Nanjing Normal University Jiangsu Key Laboratory of Mental Health and Cognitive ScienceNanjingJiangsu 210097China The Mental Health Centre of Xiangya Hospital Central South UniversityChangshaHunan 410008China The Department of Psychiatry Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsu 210029China The Children’s Hospital affiliated to the Medical College of Zhejiang University HangzhouZhejiang 310003China The Department of Medical Imaging Jinling HospitalNanjing University School of MedicineNanjingJiangsu 210002China The Second Xiangya Hospital of Central South University ChangshaHunan 410008China

Background pediatric bipolar disorder(PBD)has been proven to be related to abnormal brain structural connectivity,but how the abnormalities in PBD correlate with gene expression is debated.Objective This study aims at identification of cell-type-specific gene modules based on cortical structural differences in PBD.Methods Morphometric similarity networks(MSN)were computed as a marker of interareal cortical connectivity based on MRI data from 102 participants(59 patients and 43 controls).Partial least squares(PLS)regression was used to calculate MSN differences related to transcriptomic data in AHBA.The biological processes and cortical cell types associated with this gene expression profile were determined by gene enrichment tools.Results MSN analysis results demonstrated differences of cortical structure between individuals diagnosed with PBD and healthy control participants.MSN differences were spatially correlated with the PBD-related weighted genes.The weighted genes were enriched for“trans-synaptic signaling”and“regulation of ion transport”,and showed significant specific expression in excitatory and inhibitory neurons.Conclusions This study identified the genes that contributed to structural network aberrations in PBD.It was found that transcriptional changes of excitatory and inhibitory neurons might be associated with abnormal brain structural connectivity in PBD.

关键词： morphometric similarity Allen Human Brain Atlas pediatric bipolar disorder cell type

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