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Amelanotic primary cervical malignant melanoma:A case report and review of literature

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World Journal of Clinical Oncology 2024年第7期15卷 953-960页

作者： Jin-Lin Duan Jing Yang Yong-Long Zhang Wen-Tao Huang Department of Pathology The Affiliated Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200332China Laboratory of Targeted Therapy and Precision Medicine Department of Clinical LaboratoryShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Primary malignant melanoma of the cervix(PMMC)is an extremely rare disease that originates from primary cervical malignant melanoma and frequently re-presents a challenge in disease diagnosis due to unclarified clinical and histo-logical presentations,particularly those without *** SUMMARY Here,we report a case of amelanotic PMMC,with a history of breast cancer and thyroid *** patient was finally diagnosed by immunohistochemical staining and staged as IB2 based on the International Federation of Gynecology and Obstetrics with reference to National Comprehensive Cancer Network guide-lines and was treated with radical hysterectomy,bilateral salpingo-oophorectomy and pelvic *** then received combination therapy consisting of immunotherapy with tislelizumab and radiofrequency *** has remained free of disease for more than 1 *** The differential diagnosis process reenforced the notion that immunohisto-chemical staining is the most reliable approach for amelanotic PMMC *** to the lack of established therapeutic guidelines,empirical information from limited available studies does not provide the rationale for treatment-decision *** integrating'omics'technologies and patient-derived xenografts or mini-patient-derived xenograft models this will help to identify selective thera-peutic window(s)and screen the appropriate therapeutics for targeted therapies,immune checkpoint blockade or combination therapy strategies effectively and precisely that will ultimately improve patient survival.

关键词： Primary cervical malignant melanoma MelanA Immunotherapy patient management Case report

γ-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1014-1030页

作者： Le-Jia Sun Ai Guan Wei-Yu Xu Mei-Xi Liu Huan-Huan Yin Bao Jin Gang Xu Fei-Hu Xie Hai-Feng Xu Shun-Da Du Yi-Yao Xu Hai-Tao Zhao Xin Lu Xin-Ting Sang Hua-Yu Yang Yi-Lei Mao Department of Liver Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Gallbladder carcinoma(GBC)carries a poor prognosis and requires a prediction ***-glutamyl transferase–to–platelet ratio(GPR)is a recently reported cancer prognostic *** the mechanism for the relationship between GPR and poor cancer prognosis remains unclear,studies have demonstrated the clinical effect of both gamma-glutamyl transferase and platelet count on GBC and related gallbladder *** To assess the prognostic value of GPR and to design a prognostic nomogram for *** The analysis involved 130 GBC patients who underwent surgery at Peking Union Medical College Hospital from December 2003 to April *** patients were stratified into a high-or low-GPR *** predictive ability of GPR was evaluated by Kaplan–Meier analysis and a Cox regression *** developed a nomogram based on GPR,which we verified using calibration *** nomogram and other prognosis prediction models were compared using timedependent receiver operating characteristic curves and the concordance *** patients in the high-GPR group had a higher risk of jaundice,were older,and had higher carbohydrate antigen 19-9 levels and worse postoperative *** analysis revealed that GPR,age,body mass index,tumor–node–metastasis(TNM)stage,jaundice,cancer cell differentiation degree,and carcinoembryonic antigen and carbohydrate antigen 19-9 levels were related to overall survival(OS).Multivariate analysis confirmed that GPR,body mass index,age,and TNM stage were independent predictors of poor *** curves were highly consistent with actual *** of timedependent receiver operating characteristic curves and the concordance index showed advantages for the nomogram over TNM *** GPR is an independent predictor of GBC prognosis,and nomogram-integrated GPR is a promising predictive model for OS in GBC.

关键词： Gamma-glutamyl transferase-to-platelet ratio Gallbladder carcinoma Prognosis Nomogram Tumor-node-metastasis patient management

management of neurosurgical patients during coronavirus disease 2019 pandemics:The Ljubljana,Slovenia experience

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World Journal of Clinical Cases 2022年第15期10卷 4726-4736页

作者： Tomaz Velnar Roman Bosnjak Department of Neurosurgery University Medical Centre LjubljanaLjubljana 1000Slovenia

The novel coronavirus disease 2019(COVID-19)is an emerging disease,caused by severe acute respiratory syndrome *** bears unique biological characteristics,clinical symptoms and imaging manifestations,therefore presenting an important and urgent threat to global *** a result,a new public health crisis arose,threatening the world with the spread of the 2019 novel *** the maximal worldwide public health responses aimed at containing the disease and delaying its spread,many countries have been confronted with a critical care crisis,and even more,countries will almost certainly *** Slovenia,the COVID-19 has struck the health system immensely and among all the specialities,neurosurgery has also been experiencing difficulties in the service,not only in regular,elective surgeries but especially during *** management of these neurosurgical patients has become more difficult than *** describe our protocol in the management of neurosurgical patients in the University Medical Centre Ljubljana,Slovenia and how neurosurgical pathology was tackled during the pandemics.

关键词： Coronavirus disease 2019 Pandemic neurosurgery patient management Antivirus protocol Ljubljana

Hypertension in the elderly： insights from recent research

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Journal of Geriatric Cardiology 2010年第2期7卷 116-125页

作者： Jun-Hua Wang Shan Zhou Department of Cardiology Chinese PLA Airforce General HospitalBeijing 100036China Department of Medical Administration Chinese PLA Navy General HospitalBeijing 100048China

Hypertension is a leading cause of mortality and morbidity around the world and,prevalence of hypertension is increasing with *** in the elderly is associated with increased occurrence rates of sodium sensitivity,isolated systolic hypertension,and ＇white coat effect＇.Arterial stiffness and endothelial dysfunction also increase with *** factors should be considered in selecting antihypertensive *** prime objective of this therapy is to prevent *** fmdings of controlled trials show that there should be no cut-off age for treatment.A holistic program for controlling cardiovascular risks should be fully discussed with the patient,including evaluation to exclude underlying causes of secondary hypertension,and implementation of lifestyle *** choice of antihypertensive drug therapy is influenced by concomitant disease and previous medication history,but will typically include a thiazide diuretic as the first-line agent;to this will be added an angiotensin inhibitor and/or a calcium channel *** blockers are not generally recommended,in part because they do not combat the effects of increased arterial *** hypertension-hypoten-sion syndrome requires case-specific ***-resistant hypertension is important to differentiate from faulty compliance with *** resistant to the third-line drug therapy may benefit from treatment with extended-release isosorbide mononitrate.A trial of spironolactone may also be worthwhile.

关键词： hypertension elderly antihypertensive treatment patient management

Chinese expert consensus on prevention and treatment of delayed nausea and vomiting(2022 Edition)

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Oncology and Translational Medicine 2023年第4期9卷 147-162页

作者： Xiang-Lin Yuan Committee of Neoplastic Supportive-Care(CONS) Affiliated Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology 不详

Nausea and vomiting are common adverse reactions of antitumor therapy,among which chemotherapy-induced nausea and vomiting(CINV)has been studied most *** of insufficient prevention or insufficient attention,CINV brings a series of harms to can-cer patients and even lead to the delay or termination of antitumor *** CINV is often underestimated because it mostly occurs outside the hospital,and patients cannot report it *** recent years,the proportion of outpatient chemotherapy and day-time chemotherapy patients in China has increased year by ***,the prevention of delayed CINV is particularly ***,the challenges faced by delayed CINV include the need to deeply explore its physiological and pathological mechanisms,improve its risk assessment standards,and optimize its prevention ***,there is still lack of practice guidelines or consensus on delayed ***,the Committee of Neoplastic Supportive-Care of China Anti-Cancer Association organized multidisciplinary experts in this field to formulate this consensus based on the analysis and discussion of current evidence-based medical research in combination with clinical problems that need to be solved urgently.

关键词： Antitumor therapy Delayed CINV Expert consensus Drug therapy patient management

Nursing Care management Strategies in Isolation Wards during the COVID-19 Outbreak

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Open Journal of Nursing 2021年第4期11卷 249-257页

作者： Zhenghua Zhao Xing Lan Qinghong Chen Chengying Li Tingting Wang Xiangdong Chen Shanglong Yao Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Coronavirus disease 2019 (COVID-19) is highly infectious and has spread worldwide. Medical staff may be exposed to the infection under circumstances of medical supply shortages and improper protection. How to better protect medical staff has become the focus of all walks of life. Therefore, during the COVID-19 outbreak, timely adjustments and optimization of nursing management strategies in isolation wards are important for improving care quality and reducing the infection of medical staff. Based on a literature review and clinical nursing management practices, this article summarizes the nursing management strategies in isolation wards during the COVID-19 outbreak, aiming to provide references for clinical nursing managers.

关键词： Nursing Care management Isolation Ward COVID-19 patient management Care Quality management