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Double-side role of short chain fatty acids on host health via the gut-organ axes

Animal Nutrition 2024年第3期18卷 322-339页

作者： Yanan Gao Qianqian Yao Lu Meng Jiaqi Wang Nan Zheng Key Laboratory of Quality&Safety Control for Milk and Dairy Products of Ministry of Agriculture and Rural Affairs Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Milk and Milk Products Inspection Center of Ministry of Agriculture and Rural Affairs Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Department of Food Science Faculty of Veterinary MedicineUniversity of LiègeLiège 4000Belgium

Short chain fatty acids(SCFA)exist in dietary foods and are produced by the fermentation of gut microbiota,and are considered an important element for regulating host *** blood circulation,SCFA produced in the gut and obtained from foods have an impact on the intestinal health as well as vital organs of the *** has been recognized that the gut is the“vital organ”in the *** the gut microbial metabolites,SCFA could create an“axis”connecting the gut and to other ***,the“gut-organ axes”have become a focus of research in recent years to analyze organism *** this review,we summarized the sources,absorption properties,and the function of SCFA in both gut and other peripheral tissues(brain,kidney,liver,lung,bone and cardiovascular)in the way of“gut-organ axes”.Short chain fatty acids exert both beneficial and pathological role in gut and other organs in various ways,in which the beneficial effects are more *** addition,the beneficial effects are reflected in both preventive and therapeutic *** importantly,the mechanisms behinds the gut and other tissues provided insight into the function of SCFA,assisting in the development of novel preventive and therapeutic strategies for maintaining the host health.

关键词： Short chain fatty acid Intestinal barrier Gut-organ axis Host health Beneficial effect pathological effect

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Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

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Cellular & Molecular Immunology 2015年第6期12卷 729-742页

作者： Yang Xiao Fang Liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li Jie Yu Yi Yang Huimin Yan Mucosal immunity Research Group State Key Laboratory of Virology Wuhan institute of Virology Chinese Academy of Sciences Wuhan China

Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it is a good adjuvant candidate for vaccines, and it might function as a biological protectant against both major acute radiation syndrome during cancer radiotherapy and a mitigator of radiation emergencies. However, accumulating evidence has implicated flagellin in the occurrence of some inflammatory diseases, such as acute lung inflammation, cardiovascular collapse and inflammatory bowel disease. The aim of this study was to elucidate whether only flagellin-TLR5 signaling activation plays a role in the pathophysiology of liver or whether some other flagellin activity also contributes to liver injury either via bacterial infections or during clinical applications. Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 signaling in liver injury in wild-type and TLR5 KO mice. Gross lesions and large areas of hepatocellular necrosis were observed in liver tissue 12 h after the intraperitoneal administration of 100 or 200 pg flagellin （FliC） in a dose-and time-dependent manner in wild-type mice, but not in TLR5 KO mice. Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the subsequent acute liver function abnormality and damage. These data confirmed that flagellin is an essential determinant of liver injury and demonstrated that the over-activation of TLR5 signaling by high-dose flagellin caused acute inflammatory responses, neutrophil accumulation and oxidative stress in the liver, which contributes to the progression and severity of flagellin-induced liver injury.

关键词： flagellin liver injury pathological effect TLR5

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