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Etiology, Pathology, Management and Prognosis of Chronic Pancreatitis in Chinese Population: A Retrospective Study

Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 384-389页

作者： Soriba Naby Camara Sonam Ramdany 赵刚勾善淼熊炯炘杨智勇殷涛杨明 Oumar Taibata Balde Ahmed Boubacar Barry Seid.Adji 李想金岩吴河水王春友 Department of General Surgery Pancreatic Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of General Surgery National Hospital of Donka Department of Gastroenterology Pancreatic Center Union Hospital Tongji Medical College Huazhong University of Science and Technology

The purpose of this study was to investigate the etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population. The clinical data of 142 patients with chronic pancreatitis were retrospectively studied. All patients were of Chinese nationality and hospitalized from January 2008 to December 2011. Their ages ranged from 14 to 76 years, with a mean of 43 years. Of 142 patients, there were 72 cases of obstructive chronic pancreatitis（50.70%）, 19 cases of alcoholic chronic pancreatitis（13.38%）, 14 cases of autoimmune pancreatitis（9.86%） and 37 cases of undetermined etiology（26.06%）. pathologically, the average inflammatory mass diameter was 3.8±3.3 cm, biliary obstruction occurred in 36 cases, gall stones in 70 cases, calcification in 88 cases, ductal dilatation in 61 cases, side branch dilatation in 32 cases, ductal irregularity in 10 cases, lymphocytic inflammation in 23 cases, obliterative phlebitis in 14 cases, extra pancreatic lesion in 19 cases and fibrosis in 142 cases. Location of pancreatic lesion in the region of head（n=97）, neck（n=16）, body（n=12）, tail（n=15） and whole pancreas（n=2） influenced the choice of surgical procedures. Ninety-four patients（66.20%） received surgical treatment and 33.80% received other treatments. After operation, 80.85% of 94 patients experienced decreased pain, and 8.51% of 94 showed recovery of endocrine function but with a complication rate of 12.77%. All the operations were performed successfully. According to the pain scale of European Organization for Research and Treatment of Cancer（QLQ-C30） a decrease from 76±22 to 14±18 was observed. Etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population vary from others.

关键词： chronic-pancreatitis etiology pathological characteristics management prognosis Chinese population

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Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan Shi Jiu-Tian Huang Ling-Mei Meng He-Jun Zhang Rong-Li Cui Yuan Li Shi-Gang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 10019China Department of Gastroenterology Pathology Laboratory Peking University Third HospitalBeijing 100191China Department of Gastroenterology Peking University International HospitalBeijing 102206China

BACKGROUND The intrapapillary capillary loop(IPCL)characteristics,visualized using magnifying endoscopy,are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma(ESCC).Japan Esophageal Society(JES)classification is the most widely used *** structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor:tortuosity,dilatation,irregular caliber,and different ***,the pathological characteristics of IPCLs have not been thoroughly investigated,especially the microvascular structures corresponding to the deepest parts of the lesions'*** To investigate differences in pathological microvascular structures of ESCC,which correspond to the deepest parts of the lesions'*** Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April *** first underwent magnified endoscopic examination,followed by endoscopic submucosal dissection or surgical *** images were scanned using a threedimensional slice scanner,and the pathological structural differences in different types,according to the JES classification,were analyzed using nonparametric tests and *** The 35 lesions were divided into four groups according to the JES classification:A,B1,B2,and *** analyses revealed significant differences(aP0.05).However,significant differences in the short calibers,long calibers,and area of IPCL were observed between types B1 and B3(aP0.05).CONCLUSION pathological structures of IPCLs in the deepest infiltrating regions differ among va

关键词： Esophageal squamous cell carcinoma Intrapapillary capillary loop The Japan Esophageal Society classification Magnifying endoscopy pathological characteristics

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Clinical and pathological features in 49 elderly patients with meningiomas

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Neural Regeneration Research 2007年第9期2卷 574-576页

作者： Chuan Fang Yanli Tan Zengxue Cui Yanfang Shi Jialiang Wang Hui Di Department of Neurosurgery Affiliated Hospital of Hebei University Baoding 071000 Hebei Province China Medical College of Hebei University Baoding 071000 Hebei Province China

BACKGROUND： As aging in elderly people, their brain tissue has degeneration and brain atrophy of different severity, and the volume of cranial cavity is relatively enlarged, it has greater compensatory ability to the space occupying lesion, and it is difficult to detect the meningioma because it grows to expand slowly, the tumor locates in non-functional region, and there are atypical symptoms and deficiency of localization signs. OBJECTIVE： To investigate the clinicopathologic features of senile meningiomas. DESIGN： A retrospective analysis. SETTING： Affiliated Hospital of Hebei University. PARTICIPANTS： Forty-nine elderly patients with meningioma were selected from the Department of Neurosurgery, Affiliated Hospital of Hebei University from May 1999 to March 2005, including 15 males and 34 females, 60-74 years of age, and they were all diagnosed by CT and MRI. METHODS： The sites of tumors were identified by CT and MRI examinations in all the patients. The tumors were partially or totally resected according to their own conditions. The types of the resected tumor were pathologically observed. The conditions of postoperative recovery were observed after 1, 3 and 6 months, and without new neurological dysfunction or complication was considered as good outcome. MAIN OUTCOME MEASURES： ① Sites and pathological types of the tumor; ② Postoperative outcomes and complications. RESULTS： All the 49 patients were involved in the analysis of results. ① The tumors had wide distributions with a main location in brain convexity. Among the 49 cases of meningioma, there were 25 cases of fibrocystic type, 12 cases of meningothelial type, 6 cases of psammomatous type, 4 cases of angiomatous type and 2 cases of microcystic type. ② Among the 49 patients, 35 had good outcome, 8 had self-care ability, 4 required care by others, 2 （4.1%） died postoperatively. No long-term complication related to the operation was observed during the follow-up postoperatively. CONCLUSION： Meni

关键词： meningioma elderly patients pathological characteristics

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Cell apoptosis in perihematomal brain regions and expression of Caspase-3 protein in patients with hypertensive intracerebral hemorrhage

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Neural Regeneration Research 2006年第5期1卷 420-423页

作者： Xinqing Zhang Xiaoliang Yin Kun Zhang Zhimin Zhang Hui Cai Honglan Xu Department of Neurosurgery Beijing Chuiyangliu Hospital Beijing 100022 China Department of Pathology Beijing Chuiyangliu Hospital Beijing 100022 China

BACKGROUND： In patients with intracerebral hemorrhage （ICH）, besides the space-occupying effect of hematoma, hematomal component also causes the pathological changes of perihematomal region, including the death of neurons and glial cells, vasogenic brain edema, the destruction of blood brain barrier and so on, which are the important factors to influence the prognosis of patients. Therefore, it is necessary to perform further investigation and study on the pathological characteristics of injury and death of brain nerve cells. OBJECTIVE： To observe the pathological changes of apoptosis and Caspase-3 expression in perihematomal brain regions in patients with hypertensive ICH （HICH） in different stages of onset, and analyze their relationship. DESIGN ： Case-control observation. SETTING： Departments of Neurosurgery and Pathology of Beijing Chuiyangliu Hospital.PARTICIPANTS： Totally 19 patients with HICH, including 12 male, 7 female, aged （58.3±12.8） ranging from 49 to 78 years, whose mean volume of hemorrhage was （48.6±16.4） mL, were involved . All the cases conformed to the diagnostic criteria of intracerebral hemorrhage formulated in the 4^th National Cerebrovascular Diseases Conference and were confirmed by skull CT scanning. Informed consents of operation and specimens were obtained from the patients and relatives. METHODS： ①Patients with HICH who had undergone surgical evacuation of an intracerebral hematoma by traverse temporal lobe approach in the Department of Neurosurgery, Beijing Chuiyangliu Hospital from January 2004 to July 2005 were involved. Nineteen specimens of brain tissue from perihematomal region of HICH patients in different phases served as patient group. Five specimens were obtained from distant regions of patients in the super-early phase as the control group. According to the time from onset to operation, the 19 cases were divided into 3 groups： 6 cases in super-early phase（onset 〈 8 hours）, 8 cases in early phase （onset about 8 to 24 h

关键词： intracerebral hemorrhage cell apoptosis correlation analysis pathological characteristics immunohistochemical staining visual field signal transduction diagnostic criteria blood brain barrier protein expression measurement data temporal lobe nerve cells CT scanning brain edema

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