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A numerical method to predict the membrane tension distribution of spreading cells based on the reconstruction of focal adhesions

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 88-100页

作者： XinYue Liu Keni-chi Tsubota Yi Yu Wang Xi XiaoBo Gong Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai 200072China Key Laboratory of Hydrodynamics(Ministry of Education) Department of Engineering MechanicsSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical Engineering Chiba UniversityChiba 263-8522Japan Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China Mechanobiology Institute National University of SingaporeSingapore 117411Singapore Institut Jacques Monod UniversitéParis CitéCentre National de la Recherche ScientifiqueParis F-75013France Institute of Mechanobiology and Biomedical Engineering School of Life Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240China

Changes in membrane tension significantly affect the physiological functions of cells in various ***,directly measuring the spatial distribution of membrane tension remains an ongoing *** this study,an algorithm is proposed to determine the membrane tension inversely by executing a particle-based method and searching for the minimum deformation energy based on the cell images and focal adhesions.A standard spreading cell model is established using 3D reconstructions with images from structured illumination microscopy as the reference cell *** membrane tension distribution,forces across focal adhesions,and profile of the spread cell are obtained using this method,until the cell deformation energy function optimization *** and quantitative comparisons with previous experimental results validated the reliability of this *** results show that in the standard spreading cell model,the membrane tension decreases from the bottom to the top of the *** method can be applied to predict the membrane tension distribution of cells freely spreading into different shapes,which could improve the quantitative analysis of cellular membrane tension in various studies for cell mechanics.

关键词： cell spread membrane tension distribution particle-based method optimization method 3D reconstructions

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