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Paratyphoid fever- Emerging problem in South India

Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 815-817页

作者： Ragini Bekur K.E.Vandana K.N.Shivashankara Rohit Valsalan Vishwanath Sathyanarayanan Department of Medicine Kasturba Medical CollegeManipal UniversityManipalUdupiKarnatakaIndia-576104 Department of Microbiology Kasturba Medical CollegeManipal UniversityManipalUdupiKarnatakaIndia-576104

Objective:To review the clinical profile and drug susceptibilities of Salmonella paratyphi A in a tertiary care ***:Retrospective analyses of 113 patients with paratyphoid fever and 101 culture proven Salmonella paratyphi A infection were included in the *** study extended over a period of 3 years(2006-2008).Diagnosis of patients were based on clinical features,serology and blood *** drug susceptibility testing of the isolates were performed by the disc diffusion *** presentation,laboratory parameters,susceptibility patterns of isolates,treatment and clinical response were ***:Of the 113 cases,77(68.4%) were males and 36 were females(32.8%),which included 2 pediatric *** was the most common symptom(100.0%) followed by loose stools(37.2%),headache(35.4%),myalgia(31.9%), pain abdomen(29.2%),dry cough(19.5%) and vomiting(13.3%).All patients were clinically cured. Majority of the isolates(46%) were resistant to cotrimoxazole in 2006,however they became 100% sensitive in 2007 and *** the strains became 100% sensitive to ampicillin and chloramphenicol only in *** 2006 the sensitivity of organisms to ciprofloxacin was 89% but in 2007 and 2008 there has been an increasing resistance to ciprofloxacin(46% and 86%) *** 3 isolates(8.1%) were resistant to ceftriaxone in 2006,showed 100% sensitivity in *** drugs used were ceftriaxone in 100 cases(88.4%) and ciprofloxacin in 13 cases(11.6%).One patient had relapse of paratyphoid fever after treatment with ciprofloxacin which responded to ***:Paratyphoid fever A is one of the emerging infections and a significant problem in *** increasing resistance to fluoroquinolones is *** monitoring of drug susceptibilities is mandatory in instituting appropriate therapy.

关键词： Paratyphoid fever Salmonella paratyphi A Antimicrobial susceptibility

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