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Soft nanofiber modified micropatterned substrates enhance nativelike endothelium maturation via CXCR4/calcium-mediated actin cytoskeleton assembly

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Nano Research 2023年第1期16卷 792-809页

作者： Bingcheng Yi Boya Zhou Wufei Dai Xinwu Lu Wei Liu Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Regeneration and maturation of native-like endothelium is crucial for material-guided small-diameter vascular *** parallel-microgroove-patterned(micropatterned)substrates are capable of promoting endothelial regeneration with native-like endothelial cell(EC)alignment,their unbefitting high-stiffness acutely inhibits cell–matrix interaction and endothelial *** that the sufficient softness of nanofibers allows cells to deform the local matrix architecture to satisfy cell survival and functional requirements,in this study,an effective strategy of decorating micropatterned substrate with soft nanofibers was exploited to enhance cell–matrix interaction for engineering healthy *** demonstrated that the micropatterned nanofibrous membranes were successfully obtained with high-resolution parallel microgrooves(groove width:~15μm;groove depth:~5μm)and adequate softness(bulk modulus:2.27±0.18 MPa).This particular substrate markedly accelerated the formation and maturation of confluent native-like endothelium by synchronously increasing cell–cell and cell–matrix *** analysis revealed that compared with smooth features,the microgrooved pattern was likely to promote endothelial remodeling via integrinα5-mediated microtubule disassembly and type I interleukin 1 receptormediated signaling pathways,whereas the nanofibrous pattern was likely to guide endothelial regeneration via integrinα5β8-guided actin cytoskeleton ***,endowing micropatterned substrate with soft nanofibers was demonstrated to accelerate endothelial maturation via chemokine(C-X-C motif)receptor 4/calcium-mediated actin cytoskeleton ***,numerical simulation results of hemodynamics indicated the positive impact of the micropatterned nanofibers on maintaining stable ***,our current work supports an affirmation that the micropatterned nanofibrous substrates can significantly promote regeneration

关键词： small-diameter vascular grafts parallel microgrooves nanofibers cell-matrix interaction endothelial regeneration

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