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papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration

Nano Research 2023年第7期16卷 9792-9803页

作者： Yueyue Li Weifeng Zhong Junjie Wu Yuan Jia Zhonghua Chen Kaiwen Zhang Danyang Guo Yifei Fu Mengnan Chen Weiwei Chen Fan Tian Xia Li Hongji Zhang Xiaojin Zhou Feng-Lai Yuan Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214000China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214000China

The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound *** fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to *** fibroblasts play central regulatory roles in the regeneration of skin appendages during wound *** by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary *** the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation *** sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+*** in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound *** findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.

关键词： wound healing regeneration papillary fibroblasts recruitment

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