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Traditional Chinese medicine “Qing Yi Tang” alleviates oxygen free radical injury in acute necrotizing pancreatitis

World Journal of Gastroenterology 1998年第4期4卷 85-87页

作者： LI ZhanLiang1, WU ChengTang2, LU LianRong, ZHU XiaoFeng and XIONG DeXinKeywords pancreatitis/therapy Qing Yi Tang free radicals superoxide dismutase/analysis malonyldiadehyde/analysis 304th Hospital of PLA Beijing 100037 China Nanfang Hospital First Military Medical University Guangzhou 510515 China Kharkov Medical School Ukraine Department of Surgery China 304th Hospital of PLA Beijing 100037 51 Fucheng Rd China

AIM To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine 'Qing Yi Tang' in acute necrotizing pancreatitis (ANP).METHODS After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were *** As compared with control group, the serum level of amylase (734U/L vs 2783U/L) and MDA (7.8nmol/ml vs 14.8nmol/ml) in Chinese medicine group were decreased on day 7 (P＜0.05), while SOD increased significantly (281nU/ml vs 55nU/ml, P＜0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as *** 'Qing Yi Tang' is effective in clearing OFRs and alleviating pathological changes in ANP.

关键词： pancreatitis therapy Qing Yi Tang free radicals superoxide dismutase analysis malonyldiadehyde analysis

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