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Glucomannan for abdominal pain-related functional gastrointestinal disorders in children:A randomized trial

World Journal of Gastroenterology 2013年第20期19卷 3062-3068页

作者： Andrea Horvath Piotr Dziechciarz Hania Szajewska Department of Paediatrics the Medical University of WarsawDzialdowska 1Poland

AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized *** were recruited among children referred to the Department of Paediatrics,Medical University of *** in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic *** children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same *** content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 ***:Of the 89 eligible children,84(94%) completed the study."No pain" and "treatment success"(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool *** demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily ***:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.

关键词： Functional abdominal pain Abdominal painrelated functional gastrointestinal disorders Children

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