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Safety and efficacy of polymer-free paclitaxel-eluting microporous stent in real-world practice： 1-year follow-up of the SERY-I registry

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Chinese Medical Journal 2011年第21期124卷 3521-3526页

作者： Zhang Rui-yan Zhang Qi Zhu Jin-zhou Chen Liang-long Zhang Chen-yun Zhou Xu-chen Yuan Yong Zhong Zhi-xiong Li Lang Qiu Jian Wang Wei Chen Xi-ming Yang Zhi-jian Yan Jin-chuan Chen Shao-liang Hou Yu-qing Wu Yan-qing Luo Hai-ming Qiu Jian-ping Zhu Li Wang Yan Fu Guo-sheng Wang Jian-an Ma Kang-hua Yin Yue-hui Zhang Dai-fu Hu Xue-song Zhu Guo-ying Shen Wei-feng Shanghai Jiao Tong Univ Sch Med Dept Cardiol Ruijin Hosp Shanghai 200025 Peoples R China Fujian Med Univ Union Hosp Dept Cardiol Fuzhou 350005 Fujian Peoples R China Guizhou Prov Peoples Hosp Dept Cardiol Guiyang 550002 Guizhou Peoples R China Dalian Med Univ Affiliated Hosp 1 Dept Cardiol Dalian 116011 Liaoning Peoples R China Zhongshan Peoples Hosp Dept Cardiol Zhongshan 528400 Guangdong Peoples R China Meizhou Peoples Hosp Dept Cardiol Meizhou 514031 Guangdong Peoples R China Guangxi Med Univ Affiliated Hosp 1 Dept Cardiol Nanning 530000 Guagnxi Peoples R China Gen Hosp Guangzhou Mil Command Peoples Liberat Ar Dept Cardiol Guangzhou 510010 Guangdong Peoples R China Guangzhou Med Coll Dept Cardiol Affiliated Hosp 1 Guangzhou 510120 Guangdong Peoples R China Guangzhou Med Coll Dept Cardiol Affiliated Hosp 3 Guangzhou 510150 Guangdong Peoples R China Jiangsu Prov Hosp Dept Cardiol Nanjing 210029 Jiangsu Peoples R China Jiangsu Univ Dept Cardiol Affiliated Hosp Zhenjiang 212001 Jiangsu Peoples R China Nanjing First Hosp Dept Cardiol Nanjing 210000 Jiangsu Peoples R China So Med Univ Dept Cardiol Nanfang Hosp Guangzhou 510515 Guangdong Peoples R China Nanchang Univ Dept Cardiol Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China Shanghai Univ Tradit Chinese Med Dept Cardiol Yueyang Hosp Integrated Tradit Chinese & Western Shanghai 200437 Peoples R China Shanghai Pudong New Area Goughli Hosp Dept Cardiol Shanghai 200135 Peoples R China Jiangsu Taizhou Peoples Hosp Dept Cardiol Taizhou 225300 Jiangsu Peoples R China Xiamen Univ Dept Cardiol Zhongshan Hosp Xiamen 361004 Fujian Peoples R China Sir Run Run Shaw Hosp Dept Cardiol Hangzhou 310020 Zhejiang Peoples R China Zhejiang Univ Sch Med Dept Cardiol Affiliated Hosp 2 Hangzhou 310009 Zhejiang Peoples R China Chongqing Med Univ Dept Cardiol Affiliated Hosp 1 Chongqing 400042 Peoples R China Chongqing Med Univ Dept Cardiol Affiliated Hosp 2 Chongqing 400010 Peop

Background Polymer coating on coronary stents induces vascular inflammatory response, reduces re-endothelialization, and affects long-term outcome after percutaneous coronary intervention （PCI）. The SERY-1 registry aimed to determine whether a novel polymer-free paclitaxel-eluting microporous Yinyi stent could improve 1-year outcome after index procedure in real-world clinical practice. Methods Clinical and angiographic data and follow-up outcome were collected in 1045 patients who underwent PCI with implantation of 〉1 Yinyi stents between June 2008 and August 2009 at 27 medical centers. The primary endpoint was the cumulative rate of composite major adverse cardiac events （MACE） and the secondary endpoint was the incidence of stent thrombosis at 1 year. Results Overall, 1376 lesions were treated successfully with 1713 Yinyi stents, and 1019 （98.7%） patients received dual antiplatelet therapy for at least 12 months. During 1-year follow-up, 8 patients （0.78%） had cardiac death, 6 （0.58%） suffered non-fatal myocardial infarction, and 46 （4.46%） underwent repeat PCI due to recurrence of angina, resulting in 1-year MACE-free survival of 94.09%. stent thrombosis occurred in 10 （0.97%） patients, and the rate of Academic Research Consortium （ARC） definite or probable stent thrombosis was 0.78%. Conclusions Polymer-free paclitaxel-eluting microporous Yinyi stent is effective and safe for interventional treatment of coronary artery disease in real-world clinical practice, without recourse to carrier polymer. Potential long-term clinical advantages of this stent deserve further investigation.

关键词： polymer-free microporous stent paclitaxel-eluting stent stent thrombosis

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A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 754-761页

作者： Xiao-hong PAN Ying-xue CHEN Mei-xiang XIANG Geng XU Jian-an WANG Department of Cardiology the Seeond Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent(PES) in ST-segment elevation myocardial infarction(STEMI) patients.A systematic literature search was conducted to identify all randomized clinical trials in mortality,recurrent myocardial infarction(rMI),repeat revascularization(RR),and stent thrombosis(ST).A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent(BMS).The pooled repeat revascularization rate was 5.7% in PES group,significantly lower than 10.0% in BMS group with an odds ratio(OR) of 0.56,95% confidence interval(CI) [0.44,0.72](Pstent thrombosis with BMS(2.3% vs.2.4%,OR 0.81,95% CI [0.52,1.26],P=0.35).The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety.

关键词：心肌的梗塞 paclitaxel-eluting stent 赤裸金属的 stent 元分析

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