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Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension

癌症生物学与医学：英文版 2017年第4期14卷 405-413页

作者： Filiz Kisaayak Collak Ummuhan Demir Seyma Ozkanli Esra Kurum Pinar Engin Zerk Molecular Biology and Genetics Department Faculty of Engineering and Natural Sciences Istanbul Medeniyet University Istanbul 34700 Turkey pathology Department Faculty of Medicine Istanbul Medeniyet University Istanbul 34700 Turkey Statistics Department University of California Riverside Riverside CA 92521 USA

Objective:Yes associated protein 1(YAP1)is a member of the Hippo pathway,acting as a transcriptional *** elucidate the role of YAP1 and phosphorylated(p)YAP1 in prostate cancer(PCa)tumorigenesis,we investigated their expression in clinical samples of PCa and cell ***:Fifty-four tumor,adjacent nontumor,and prostate intraepithelial neoplasia(PIN)tissues from patients with PCa after radical prostatectomy were selected from a retrospective cohort and studied using immunohistochemistry(IHC).Protein and m RNA expression levels of YAP1 were evaluated by Western blot analysis and quantitative real-time reverse transcription PCR,respectively,in cancer cell *** available gene expression datasets were downloaded to analyze YAP1 m RNA and protein levels in PCa tissue ***:IHC analysis of PCa tissues revealed that YAP1 staining intensities were moderate to weak in the nucleus and cytoplasm of tumor cells,whereas adjacent normal epithelia showed strong *** observed that benign prostates were characterized by higher expression levels of both nuclear(P=0.004)and cytosolic(P=0.005)YAP1.p YAP1 staining was weak in the cytoplasm and absent in the nucleus of all the tissues ***1 expression was an indicator of extraprostatic extension(EPE).The level of YAP1 was negatively correlated with the level of the androgen receptor(AR)in The Cancer Genome Atlas dataset and Western blot analysis of cell ***:Our study suggested that YAP1 expression is heterogeneous in PCa tissue samples;therefore,YAP1 might play different roles in different aspects of PCa *** might involve AR–YAP1 interplay in PCa.

关键词： YAP1 pyap1 PCa

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