检索结果-南通市图书馆

p53 gene therapy in combination with transcatheter arterial chemoembolization for HCC:One-year follow-up

World Journal of Gastroenterology 2011年第16期17卷 2143-2149页

作者： Yong-Song Guan Yuan Liu Qing He Xiao Li Lin Yang Ying Hu Zi La Department of Oncology West China HospitalSichuan University Chengdu 610041 Sichuan Province China

AIM:To evaluate the efficacy and safety of combination therapy with recombinant adenovirus p53 injection (rAdp53) and transcatheter hepatic arterial chemoembolization (TACE) for advanced hepatocellular carcinoma (HCC).METHODS:A total of 82 patients with advanced HCC treated only with TACE served as control *** 68 patients with HCC treated with TACE in combination with recombinant adenovirus-p53 injection served as p53 treatment *** were followed up for 12 *** and therapeutic effects were evaluated according to the improvement in clinical symptoms,leukocyte count,Karnofsky and RECIST *** rate was calculated with Kaplan-Meier ***:The total effective rate was 58.3% for p53 treatment group,and 26.5% for control group (p ptoms was lower in p53 treatment group than in control group (p p53 treatment group than for control group (p p=0.006) and pain of muscles and joints (13.2%,p=0.003),which were significantly higher than the *** for these minor adverse effects,no severe vector-related complications were *** respect to the efficacy,patients in p53 treatment group had less gastrointerestinal symptoms (p=0.062),better improvement in tumor-related pain (p=0.003),less downgrade of leukocyte counts (p=0.003) and more upgrade of Karnofsky performance score (p=0.029) than those in control *** total effective rate (CR + pR) for p53 treatment group and control group was 58.3% and 26.5%,respectively,with distributions of different effect in two groups (p=0.042).The survival rates were 89.71%,76.13%,and 43.30% for p53 treatment group,and 68.15%,36.98%,and 24.02% for control group,respectively,3,6 and 12 mo after treatment,suggesting that the survival rates are significantly higher for p53 tre

关键词： Adenovirus p53 Clinical trial Hepatocellular carcinoma Transcatheter hepatic arterial chemoembolization p53 gene therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：