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Oncogenic Role of Skp2 and p27^(kip1) in Intraductal proliferative Lesions of the Breast

Chinese Medical Sciences Journal 2012年第3期27卷 161-166页

作者： Yan Lv Yun Niu Xiu-min Ding Xu-qi Xiao Department of Acupuncture and Moxibustion Tianjin University of Traditional Chinese MedicineTianjin 300193China Breast Cancer Research and pathology Laboratory Cancer Institute&Hospital of Tianjin Medical UniversityTianjin 300060China

Objective To investigate whether the connection of p27 kip1 to S-phase kinase-associated protein 2 (Skp2) plays an oncogenic role in intraductal proliferative lesions of the breast. Methods Here we investigated the mechanism involved in association of Skp2's degradation of p27 kip1 with the breast carcinogenesis by immunohistochemical method through detection of Skp2 and p27 kip1 protein levels in 120 paraffin-embedded tissues of intraductal proliferative lesions including usual ductal hyperplasia (UDH, n=30), atypical ductal hyperplasia (n=30), flat epithelial atypia (FEA, n=30), and ductal carcinoma in situ (DCIS, n=30). Moreover, the expression status of Skp2 and p27 kip1 in 30 cases of the normal breast paraffin-embedded tissues were explored. Results The DCIS group was with the highest Skp2 level and the lowest p27 kip1 level, and the UDH group was with the lowest Skp2 level and the highest p27 kip1 level. Both Skp2 and p27 kip1 levels in the DCIS group were significantly different from those in the UDH group (all pp2 and p27 kip1 in the FEA group were significantly different from both the DCIS and UDH groups (all pp27 kip1 was negatively correlated with Skp2 in both the UDH group (r=-0.629, p=0.026) and DCIS group (r=-0.893, p=0.000). Conclusion Overexpression of Skp2 might be the mechanism underlying p27 kip1 over degradation.

关键词： breast cancer intraductal proliferative lesions p27 ^kip1 S-phase kinase-associated protein 2

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