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Journal of Renewable Materials 2023年第2期11卷 555-566页

作者： Tanhao Zhang Shuo Zhang Wu Lan Fengxia Yue State Key Laboratory of pulp and paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510640China

Ferulic acid(FA)and p-coumaric acid(pCA)in bagasse,wheat straw,corn straw,and corncob were extracted by alkaline hydrolysis and characterized by gas chromatography(GC)and gas chromatography-mass spectrometry(GC-MS).It was found that the FA and most of the pCA in gramineous biomass could be dissociated and released after being treated with 1 M NaOH at 100℃for 4 h.The yields of pCA/FA in bagasse,wheat straw,corn straw,and corncob determined by GC-FID are 39.8/11.5,13.7/11.0,28.0/11.0,and 35.1/14.5 mg/g,respectively.The raw materials and the treated solid residues were characterized by gel-state 2D Heteronuclear Single Quantum Coherence Nuclear Magnetic Resonance(2D HSQC NMR).It was found that only a small amount of lignin was detected in the residue after alkali treatment,indicating that the alkali treatment conditions can effectively cleave the FA and pCA.Additionally,the lignin in the alkali solution was recovered and characterized by 2D HSQC NMR.The FA was not able to be detected by NMR,whereas a small amount of pCA remained in the alkali lignin.This study reveals the structural change of residual lignins during the quantitative isolation of FA and pCA,which is essential for the selective isolation of pCA/FA and valorization of residual alkali lignin.

关键词： Gramineae ferulic acid p-coumaric acid alkali lignin alkaline pretreatment

p-coumaric acid alleviates adriamycin-induced hepatotoxicity in rats

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Asian pacific Journal of Tropical Biomedicine 2021年第3期11卷 115-121页

作者： Zeinab Rafiee Maasoumeh Zare Moaiedi Armita Valizadeh Gorji Esrafil Mansouri Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Clinical Biochemistry Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Bone Marrow Transplantation Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Cellular and Molecular Research Center Department of Anatomical SciencesFaculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Objective:To evaluate the effect of p-coumaric acid against adriamycin-induced hepatotoxicity in rats.Methods:The rats were divided into 4 groups.The control group received solvent;the p-coumaric acid group was treated with 100 mg/kg of p-coumaric acid orally for five consecutive days;the adriamycin group was administered with a single dose of adriamycin(15 mg/kg,i.p.),and the p-coumaric acid+adriamycin group was given p-coumaric acid five days before adriamycin administration.Twenty-four hours after the last administration,blood samples were collected for biochemical analysis,and liver tissues were removed for histopathological and immunohistochemistrical studies.Moreover,the levels of tissue lipid peroxidation and enzyme activities of glutathione peroxidase,superoxide dismutase,and catalase in liver tissue were measured.Results:Treatment with p-coumaric acid protected the liver from the toxicity of adriamycin by attenuating the increase in alkaline phosphatase,alanine transaminase,aspartate transaminase,total bilirubin,total cholesterol,triglyceride,and low-density lipoprotein cholesterol and lessening the decrease in high-density lipoprotein cholesterol and albumin.p-coumaric acid also raised the levels of glutathione peroxidase,superoxide dismutase,and catalase,as well as decreased lipid peroxidation in liver tissue and hepatic IL-1βexpression.Additionally,histopathological study confirmed the protective effect of p-coumaric acid against liver damage.Conclusions:p-coumaric acid can alleviate adriamycin-induced hepatotoxicity.

关键词： Adriamycin Hepatotoxicity p-coumaric acid Antioxidant IL-1β

Simultaneous determination of gallic acid and p-coumaric acid in rat plasma by UpLC-MS/MS and its application to a comparative pharmacokinetic study after oral administration of monomer compound and red wine extract

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Journal of polyphenols 2019年第1期1卷 1-11页

作者： Huijie Lv Mengyu Zou Weichao Yu Baoshan Sun Yan Cui School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Jiangsu Hengrui pharmaceutical Co. LtdLianyungang 222002China School of pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China pólo Dois portos Instituto National de Investigação Agrária e VeterináriaI.P.Quinta da AlmoinhaDois Portos 2565-191Portugal

A rapid,sensitive and selective ultra high performance liquid chromatography-tandem mass spectrometry(UpLCMS/MS)method was developed and validated for simultaneous determination of gallic acid(GA)and p-coumaric acid(CA)in rat plasma.plasma samples were extracted by methanol and separated on an ACQUITY UpLC BEH C18 column(1.7μm,100 mm×2.1 mm)using gradient elution consisting of acetonitrile–0.2%formic acid within a runtime of 4.0 min.The detection was performed in multiple reaction monitoring(MRM)mode with negative ionization.The linear range was 20–20000 ng/mL for both GA and CA,with lower limits of quantification of 20 ng/mL.Intra-day and inter-day precisions were within 5.4%and 10.0%,respectively and the accuracy(relative error,RE,%)was less than 7.2%and–4.9%,respectively.The mean absolute extraction recoveries of both analytes and IS from rat plasma were all more than 82.6%.The validated method was successfully applied to the comparative pharmacokinetic study of GA and CA in rat plasma after oral administration of GA and CA monomers and red wine extract,respectively.It was found that both the area under the curve(AUC)and t1/2 of the two constituents were remarkably increased for red wine extract group than that in monomer group,indicating the priority of intake of red wine to active component monomer.

关键词： gallic acid p-coumaric acid red wine extract UpLC-MS/MS pharmacokinetics

Combinatorial engineering of L-tyrosine biosynthesis pathway for improved p-coumaric acid production in Saccharomyces cerevisiae

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Combinatorial engineering of L-tyrosine biosynthesis pathway...

Mono-and dioleyl p-coumarate phenolipids and their antioxidant activity in a muscle food model system

中国生物化学与分子生物学会2016年全国学术会议

作者： Jiwei Mao Yuzhen Wu Yiming Cheng Xiaofei Song Yanling Bai Haijin Xu Xiuming Zhang Mingqiang Qiao Key Laboratory of Molecular Microbiology and Technology Ministry of Education Nankai University Department of Microbiology College of Life Sciences Nankai University

S.cerevisiae has been extensively engineered as a cell factory platform for flavonoids production.The first step of flavonoids biosynthesis pathway is catalyzed the conversion of tyrosine to p-coumaric acid by tyrosine ammonia lyase,which is also a rate-limiting step for many secondary metabolites in plants.Here we designed a combinatorial metabolic engineering

关键词： Saccharomyces cerevisiae L-tyrosine p-coumaric acid metabolic engineering gene over-expression

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Food Production, Processing and Nutrition

Food production, processing and Nutrition 2022年第1期4卷 72-84页

作者： Jiankang Wang Xiaojia Hu Yan Huang Ye Zou Linxiao Han Daoying Wang Fereidoon Shahidi School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi’an710021People’s Republic of China Institute of Agricultural products processing Jiangsu Academy of Agricultural SciencesNanjing210014People’s Republic of China Department of Biochemistry Memorial University of NewfoundlandSt.John’sNLA1C 5S7Canada

Response surface methodology (RSM) was used to optimize the degree of esterification of p-coumaric acid to triolein via lipase-catalyzed acidolysis, and enzyme load, reaction time and mole ratio of substrates were selected as variables in the experimental design. The results showed that the model employed was highly sufficient for determining the effectiveness and interaction of three selected variables, enzyme load, reaction time and the mole ratio of substrates, on the dependent variable, the degree of esterification. Although the optimization point was not found in the selected range of the three variables, the steepest ascent analysis suggested that an increase of these three variables might lead to a stationary point. However, based on the limitations on increasing the range of tested variables, including possible oxidation of synthesized lipids and increased cost, the degree of esterification so yielded in the designed central composite design should be the one closest to the possible ideal optimized degree. The p-coumarates so produced exhibited varying antioxidant performance in the tested muscle food model, which could be explained by their different lipophilicity. Moreover, the potential health benefits of synthesized phenolic lipids have been discussed.

关键词： Response surface methodology acidolysis p-coumaric acid Monooleyl p-coumarates Dioleyl p-coumarates Antioxidant activity

Induced Effects of Exogenous phenolic acids on Allelopathy of a Wild Rice Accession(Oryza longistaminata,S37)

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Rice science 2010年第2期17卷 135-140页

作者： Xu Gao-feng ZHANG Fu-dou LI Tian-lin Wu Di ZHANG Yu-hua Agricultural Environment ＆ Resource Research Institute Yunnan Academy of Agricultural Sciences Kunming 650205 China

Four exogenous phenolic acids, including salicylic acid, fumalic acid, p-coumaric acid and p-hydroxybenzonic acid, were used to investigate the regulatory effects on allelopathy of a wild rice accession of S37 （Oryza Iongistaminata）, which is a known allelopathic rice. The four exogenous phenolic acids induced the enhancement of the allelopathic potential of wild rice S37 in target weeds though the weed-suppressive activities were low, and the inducible effects were dependent on the specific phenolic acid, concentration and treatment time. After foliar application of exogenous phenolic acids, the inhibition rates for plant height, root length and fresh weight of barnyard grass （Echinochioa crus-galli） were significantly higher than those of the control. Especially at the concentration of 100 mg/L, the inhibition rates for plant height and fresh weight of barnyard grass by fumalic acid were 38.12% and 26.31% higher than those of the control, showing that fumalic acid was more effective compared with other phenolic acids in inhibiting monocotyledon weed growth. Furthermore, the weedsuppressive activity of aqueous extract from the leaves of wild rice S37 treated with exogenous phenolic acids was increased, and it peaked at 48 h after the treatment with the aqueous extract, and then gradually declined.

关键词： salicylic acid fumalic acid p-coumaric acid p-hydroxybenzoic acid phenolic acid allelopathy inducible effect Oryza Iongistaminata