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Journal of Environmental Sciences 2018年第11期30卷 9-19页

作者： Yang Li Tinglin Huang Xinlin Tan Zizhen Zhou Weixing Ma Key Laboratory of Northwest Water Resource Environment and EcologyMOEXi'an University of Architecture and Technology Shaanxi Key Laboratory of Environmental Engineering Xi'an University of Architecture and Technology

Thermal stratification is a common phenomenon in lakes and reservoirs and has a significant influence on water quality dynamics. Heihe Reservoir is a canyon-shaped reservoir in Shaanxi Province with strong thermal stratification. Therefore, eight water-lifting aerators （WLAs） were installed in this reservoir, which could overcome thermal stratification and increase oxygenation with gas flows between 20 and 50 m3/hr, and oxygenate the hypolimnion with gas flows less than 20 m3/hr. To examine the destratification efficiency of the WLA system, we used a three- dimensional hydrodynamic module based on MIKE 3 to simulate the thermal structure of Heihe Reservoir and compared the simulations with measured data. Results showed that operation of the WLA system promoted water mixing and effectively oxygenated the hypolimnion. Through the established energy utilization assessment method, the energy utilization efficiency of the WLA system was between 5.36% and 7.30%, indicating the capability of the technique for destratification in such a large reservoir. When the surface water temperature dropped to the theoretical mixed water temperature calculated by the energy utilization assessment method, reducing gas flow could save energy. This would prevent anaerobic conditions from occurring in the bottom water and maintain good water quality in Heihe Reservoir.

关键词： Reservoir Thermal stratification Numerical simulation Water-lifting aerator Mixing oxygenation

oxygenation alleviates waterlogging‑caused damages to cherry rootstocks

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Molecular Horticulture 2023年第1期3卷 283-305页

作者： Yuxuan Wang Yan Xu Jieming Xu Wanxia Sun Zhengxin Lv Muhammad Aamir Manzoor Xunju Liu Zhiyu Shen Jiyuan Wang Ruie Liu Matthew DWhiting Songtao Jiu Caixi Zhang Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Department of Horticulture Washington State UniversityProsserWA 99350USA

Waterlogging has occurred more frequently in recent years due to climate change,so it is a huge threat to crop yield and *** cherry,a fruit tree with a high economic value,is sensitive to waterlogging *** of the most effective methods for enhancing the waterlogging tolerance of sweet cherries is to select waterlogging-tolerant ***,the waterlogging tolerance of different cherry rootstocks,and the underlying mechanism remains ***,we first evaluated the waterlogging resistance of five sweet cherry rootstocks planted in *** data showed that‘Gisela 12’and‘Colt’were the most waterlogging-sensitive and-tolerant among the five tested varieties,*** effectively alleviated the adverse impacts of waterlogging stress on cherry ***,we found that the waterlogging group had lower relative water content,Fv/Fm value,net photosynthetic rate,and higher antioxidant enzyme activities,whereas the oxygenated group performed better in all these ***-Seq analysis revealed that numerous DEGs were involved in energy production,antioxidant metabolism,hormone metabolism pathways,and stress-related transcription *** findings will help provide management strategies to enhance the waterlogging tolerance of cherry rootstocks and thereby achieve higher yield and better quality of cherries.

关键词： Cherry Waterlogging Hypoxia oxygenation Transcriptome analysis

A smart MnO_(2)-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

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Acta Pharmaceutica Sinica B 2021年第3期11卷 823-834页

作者： Peng Liu Xin Xie Miao Liu Shuo Hu Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China School of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic ***,tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants,such as glutathione(GSH),which greatly restricts the therapeutic ***,a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic *** our system,a novel multifunctional nanosystem based on MnO_(2)-doped graphene oxide(GO)was developed to co-load cisplatin(Cis Pt)and a photosensitizer(Ce6).With Mn O_(2)doping,the nanosystem was equipped with intelligent functionalities:(1)catalyzes the decomposition of H_(2)O_(2)into oxygen to relieve the tumor hypoxia;(2)depletes GSH level in tumor cells,and(3)concomitantly generates Mn^(2+)to proceed Fenton-like reaction,all of which contribute to the enhanced anti-tumor ***,the surface hyaluronic acid(HA)modification could facilitate the targeted delivery of the nanosystem into tumor cells,thereby resulting in amplified cellular toxicity,as well as tumor growth inhibition in nude mice *** work sheds a new light on the development of intelligent nanosystems for synergistic combination therapy via regulating tumor microenvironment.

关键词： Cisplatin Nanoparticles Photosensitizer Tumor microenvironment oxygenation GSH depletion Nanozyme Targeting

Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

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Neural Regeneration Research 2019年第4期14卷 666-672页

作者： Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud Laboratory of Clinical Neuroscience Faculty of Medicine Department of Neurosurgery University Hospital of Fez Laboratory of Neuroendocrinology and Nutritional and Climatic Environment Faculty of Sciences Dhar El Mahraz Department of Biophysics and Clinical MRI Methods Faculty of Medicine Department of Radiology and Clinical Imaging University Hospital of Fez Department of Psychiatry University Hospital of Fez Aix Marseille Université INSERM INS Institut de Neurosciences des Systèmes

Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.

关键词： Parkinson’s disease emotion processing Blood oxygenation level-dependent functional magnetic resonance imaging brain activation dopamine neural regeneration

Synthesis, oxygenation and catalytic performance of manganese complex with p-aminomethyl benzoic acid Schiff base

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Journal of Central South University of Technology 2007年第6期14卷 793-797页

作者：刘丰良李元建黄可龙肖震 School of Chemistry and Chemical Engineering Central South University School of Pharmeutical Central South University

The amino acid Schiff base complex (Sal-AMBA-Mn) was prepared with p-amino-methylbenzoic acid, salicylaldehyde and Mn(OAc)2·4H2O. Its structures was characterized with IR and UV spectra. oxygenation mechanism of the complex in N, N-dimethylformamide solution was investigated. The results show that lower temperature is in favor of the oxygenation, and energy, enthalpy and entropy are -3.8 kJ/mol, -4.2 J/mol and -161.44 J/(mol·K), respectively. In the presence of the manganese complex, dehydroepiandrosterone acetate is effectively oxidized by molecular oxygen and the corresponding enone 7-ketodehydroepiandrosterone acetate is obtained. The yield is 62.1% when the oxidation is carried out under the reaction conditions of 60 ℃, 2 MPa of O2 pressure, C5H5N as a solvent and molar ratio of the substrate to the complex of 1:10.

关键词： amino acid Schiff base manganese complex oxygenation catalysis dehydroepiandrosterone acetate aerobic oxidation

Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy

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Bioactive Materials 2022年第4期7卷 131-144页

作者： Meiqi Chang Wei Feng Li Ding Hongguang Zhang Caihong Dong Yu Chen Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444PR China College of Pharmacy Qiqihar Medical UniversityQiqihar161006PR China Department of Ultrasound Zhongshan HospitalFudan Universityand Shanghai Institute of Medical ImagingShanghai200032PR China

Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy(PDT).Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT,but is limited by scant penetration depth and efficiency of external ***,aiming at the dual purposes of reducing biological toxicity induced by long-term light irradiation and alleviating hypoxia,we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material(PLM)as the in vivo light source after pre-excited in *** ingenious construction of blue-emitting PLM with“optical battery”characteristics activates cyanobacterial cells and verteporfin simultaneously,which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation,resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition *** in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic *** work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment,which is expected to promote the clinical progress of microbial-based photonic therapy.

关键词： Photodynamic therapy Cyanobacteria Persistent luminescence oxygenation Irradiation-free

Enhancing oxygenation of patients with coronavirus disease 2019: Effects on immunity and other health-related conditions

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World Journal of Clinical Cases 2021年第19期9卷 4939-4958页

作者： Ayman Mohamed Motaz Alawna Department of Physiotherapy and Rehabilitation Istanbul Gelisim UniversityIstanbul 34522Turkey Department of Basic Science and Biomechanics Faculty of Physical TherapyBeni Suef UniversityBeni Suef 62521Egypt Department of Physiotherapy and Rehabilitation Faculty of Allied Medical SciencesArab American UniversityJenin 24013Palestine

Coronavirus disease 2019(COVID-19)distresses the pulmonary system causing acute respiratory distress syndrome,which might lead to *** is no cure for COVID-19 ***-19 is a self-limited infection,and the methods that can enhance immunity are strongly *** oxygenation is one safe and effective intervention to enhance immunity and pulmonary *** review deliberates the probable influences of enhancing oxygenation on immunity and other health-connected conditions in patients with *** extensive search was conducted through Web of Science,Scopus,Medline databases,and EBSCO for the influence of enhancing oxygenation on immunity,pulmonary functions,psycho-immune hormones,and COVID-19 risk *** search included clinical trials and literature and systematic *** search revealed that enhancing oxygenation has a strong effect on improving immunity and pulmonary functions and psycho-immune ***,enhancing oxygenation has a self-protective role counter to COVID-19 risk ***,this search revealed the recommended safe and effective exercise protocol to enhance oxygenation in patients with *** oxygenation should be involved in managing patients with COVID-19 because of its significant effects on immunity,pulmonary functions,and COVID-19 risk factors.A mild to moderate cycling or walking with 60%-80%Vo2max for 20-60 min performed 2-3 times per week could be a safe and effective aerobic exercise program in patients with COVID-19 to enhance their immunity and pulmonary functions.

关键词： oxygenation COVID-19 Immunity Pulmonary functions Psycho-immune hormones COVID-19 risk factors

Unexpected complication during extracorporeal membrane oxygenation support: Ventilator associated systemic air embolism

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World Journal of Clinical Cases 2018年第9期6卷 274-278页

作者： Se-Min Ryu Sung-Min Park Department of Thoracic and Cardiovascular Surgery Kangwon National University Hospital School of Medicine Kangwon National Univerity

Systemic air embolism through a bronchovenous fistu-la(BVF) has been described in patients undergoing positive-pressure ventilation. However, no report has mentioned the potential risks of systemic air embolism through a BVF in patients undergoing extracorporeal membrane oxygenation(ECMO). Positive-pressure ventilation and ECMO support in patients with lung injury can increase the risk of systemic air embolism through a BVF. Increased alveolar pressure, decreased pulmonary venous pressure, and anticoagulation are thought to be the factors that contribute to this complication. Here, we present a case of systemic air embolism in a patient with ECMO and mechanical ventilator support.

关键词： Air embolism Extracorporeal membrane oxygenation Cerebral embolism Positive-pressure ventilation Cardio-pulmonary resuscitation

Supraglottic jet oxygenation and ventilation(SJOV) for resuscitation of injured soldiers and people in war field

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Military Medical Research 2022年第6期9卷 757-758页

作者： Hua-Feng Wei Department of Anesthesiology and Critical Care Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Dear Editor,Soldiers or people in battlefield settings are frequently injured with acute trauma, resulting in respiratory depression, hypoxia and associated morbidity and mortality. Traumatic brain injury(TBI) is with as much as 80%–90% of mild to moderate in combat casualties and contributed significantly to morbidity and mortality in battlefield settings. Correction of hypoxia at as capable as possible is expected to reduce or minimize the morbidity/mortality due to acute brain injury. An easy, quick and safe setup to promote oxygenation/ventilation of injured military personnel or peoples by non-medical personnel in battlefield settings immediately after acute injury before transfer to hospital is expected to reduce the morbidity/mortality due to injury mediated respiratory depression.

关键词： Battlefield War Trauma Acute injury Respiratory depression Hypoxia oxygenation Resuscitation Supraglottic jet oxygenation and ventilation(SJOV)

Proton beam therapy in apneic oxygenation treatment of an unresectable hepatocellular carcinoma: A case report and review of literature

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World Journal of Hepatology 2018年第10期10卷 772-779页

作者： Yi-Lan Lin Department of Radiation Oncology Rinecker Proton Therapy Center

Presented here is the clinical course of a 63-yearold patient with a central, large and unresectable hepatocellular carcinoma(HCC) with liver metastases and tumor invasion of the portal and hepatic veins. After the tumor had been diagnosed, the patient was immediately treated with proton beam therapy(PBT), at a total dose of 60 Gy(relative biological effectiveness) in 20 fractions administered within 4 wk. To manage the respiratory movements, at the Rinecker Proton Therapy Center, apneic oxygenation was given daily, under general anesthesia. The patient tolerated both the PBT and general anesthesia very well, and did now show any signs of acute or late toxicity. The treatment was followed by constant reductions in the tumor marker alpha-fetoprotein and the cholestatic parameters gamma-glutamyltransferase and alkaline phosphatase. The patient commenced an adjuvant treatment with sorafenib, given at 6-wk intervals, after the PBT. Follow-up with regular magnetic resonance imaging has continued for 40 mo so far, demonstrating remarkable shrinkage of the HCC(maximal diameter dropping from approximately 13 cm to 2 cm). To date, the patient remains free of tumor recurrence. PBT served as a safe and effective treatment method for an unresectable HCC with vascular invasion.

关键词： Particle therapy Proton beam therapy Apneic oxygenation Unresectable Vascular invasion Hepatocellular carcinoma Intrahepatic metastasis