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Application of the Reactive oxygen-based Cervical Exfoliated Cell Staining Solution in Clinical Cervical Cancer Screening

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Wuhan University Journal of Natural Sciences 2019年第3期24卷 233-237页

作者： GAO Fei Lü Qiongying ZHANG Wei XIAO Chengrong XIANG Qunying LI Lijia State Key Laboratory of Hybrid Rice/College of Life Sciences Wuhan University Gynecological Department Zhongnan Hospital of Wuhan University Central China Institutes of Biomedical Sciences Maternity and Child Care Hospital

We developed a special methylene blue solution for staining of cervix shedding cells based on catalytic oxidizing chromogenic reaction, which shows a potential for cervical cancer cytology screening. We screened a total of 1 922 women for cervical cancer with the special methylene blue staining method and a conventional Pap smear method using cervix shedding cells. Then, the patients with positive indicators of the Pap smear or this special solution staining method were examined by the electron colposcopy and histopathological examination. Staining of cervical exfoliated cells with this reactive oxygen-based special solution showed that the number of positive cases was 140(7.28%). Among them, 21 cases showed dark green(1.09%), and 119 cases showed purple black(6.19%). The results of the Pap smear method showed that the number of positive cases was 123(6.40%), of which ASCUS was 105(5.46%), ASC-H was 5(0.26%), and LSIL was 9(0.47%), and HSIL was 4(0.21%). For cervical exfoliated cell special staining solution for screening cervical intraepithelial neoplasia(CIN-Ⅱ, CIN-Ⅲ) and cervical cancer, sensitivity was 83.33%, specificity was 65.52%, accuracy was 74.29%, missed diagnosis rate was 13.33%, positive coincidence rate was 51.43%, and the negative coincidence rate is 86.67%. Our results proved the value of this method for early screening of cervical cancer through clinical practice in China.

关键词： preliminary screening of cervical cancers a reactive oxygen-based method for staining of cervix shedding cells sensitivity specificity

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