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Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

Chinese Journal of Natural Medicines 2017年第12期15卷 938-943页

作者： YANG Xue-Yan ZHANG Yi-Fan LIU Li-Jia WANG Yi SHANG Ming-Ying XU Feng LIU Guang-Xue CAI Shao-Qing Department of Natural Medicine School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191China

A new lignan, tirpitzin A(17) together with 20 known compounds(1-16, and 18-21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7-21 were isolated from Linaceae family for the first time. The pharmacological activity of the crude extracts was tested using a mouse inflammation model induced by dimethyl benzene. The results demonstrated that the ethyl acetate soluble fraction had anti-inflammatory activity. Moreover, the cytotoxic and anti-inflammatory activities of some compounds were studied. The new compound 17 showed moderate cytotoxic effect against Bx PC-3 cell line(IC_50 = 19.51μmol·L^(-1)) and Compound 10 showed significant cytotoxicity against Hep G2, HL-60, U87 and Bx PC-3 cell lines with IC_50 values in the range 4.2-8.3μmol·L^(-1). Additionally, Compounds 2, 10, 11, and 13 exhibited potent inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages at the concentration of 50μmol·L^(-1).

关键词： Tirpitzia ovoidea Linaceae Lignans Diterpenes Cytotoxic activity Anti-inflammatory activity

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Investigations into <i>Amanita ovoidea</i>(Bull.) Link.: Edible or Poisonous?

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Natural Resources 2014年第6期5卷 225-232页

作者： Marco Biagi Lisa Martelli Claudia Perini Luigi Di Lella Elisabetta Miraldi Dipartimento di Scienze Fisiche della Terra e dell'Ambiente Sez. Biologia Farmaceutica Università degli Studi di Siena Siena Italy Dipartimento Scienze della Vita Università degli Studi di Siena Siena Italy

It is widely known that the genus Amanita includes various taxa: edible and inedible, dangerous and sometimes even deadly species. Despite the number of studies carried out on this genus, the toxicity of some species, such as the group of white fungi, remains dubious. Hence Amanita ovoidea (Bull.) Link. is considered as edible and even tasty both popularly and in some scientific publications, and as poisonous in others, having caused various cases of poisoning. This study stems from a case of poisoning by A. ovoidea in Siena (Italy). Tests were performed with the aim of finding a scientific answer regarding the real edibility or inedibility of A. ovoidea. Analyses included phytochemical screening, toxicological tests on human ex vivo peripheral blood mononuclear cells, and measurements of soil and mushroom pollution by heavy metals.

关键词： Amanita ovoidea Chemical Composition Cell Viability Heavy Metals Italy

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