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A Case of Low-Grade Appendiceal Mucinous Neoplasm of Its Difficultly to Distinguish from a Right ovarian tumor Due to Postmenopause

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1140-1146页

作者： Tsutomu Muramoto Kyosuke Kamijo Megumi Sano Yuki Ibuki Atushi Mori Yaeko Kobayashi Nagano Municipal Hospital Department of Obstetrics and Gynecology Nagano Japan

We here present a rare case of appendiceal tumor mimicking ovarian tumor in menopause woman. The patient was a 56-year-old woman, G1P1, who presented to our hospital with a right adnexal cyst diagnosed at another hospital. Transvaginal echocardiography showed a cyst in the right adnexal region, and pelvic contrast-enhanced MRI revealed a small cyst in the same region. The left ovary was atrophic and identifiable. It was unclear whether the cyst was contiguous with the gastrointestinal tract. Blood tests showed no elevation of tumor markers. We considered its possibility of a gastrointestinal origin, but since right normal ovary was not found, we thought the tumor was of ovarian origin and decided on a laparoscopic resection of the right adnexa. Intraoperatively, we observed atrophied bilateral normal ovaries, and the pelvic tumor was contiguous to the appendix. Surgeons performed a laparoscopic appendectomy after consultation with us. After resection we searched the abdominal and pelvic cavities, but found no obvious disseminated lesions. The histological diagnosis was low-grade appendiceal mucinous neoplasm (LAMN), a rare benign tumor of the appendix. Appendiceal tumors can be difficult to differentiate from right ovarian tumors due to their close anatomic location in the pelvis. It is possible to determine whether the tumor is of ovarian or appendiceal origin by identifying normal ovaries and the location of the feeding vessels into the tumors. In our case, there were no lesions other than the appendix, but LAMN can metastasize to the ovary, cause pseudomyoxoma peritonei, or be an overlapping tumor with an ovarian tumor. If an appendiceal tumor is diagnosed after surgery for ovarian tumor, the intra-abdominal cavity should be searched for metastasis or dissemination, and a thorough search for ovarian lesions should be performed with the possibility of an overlapping tumor in mind.

关键词： Low-Grade Appendiceal Mucinous Neoplasm ovarian tumor Menopause Woman

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Premature Puberty Revealing an ovarian tumor in a Five-Year-Old Girl

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Open Journal of Pediatrics 2023年第2期13卷 153-157页

作者： Senkaye-Lagom Aimée Kissou Yacouba Traoré Oumar Ganamé Aïda Traoré/Tankoano Mariane Kabré Emile Bandré Departement of Pediatrics CHU Sourô SANOU (CHUSS) Bobo-Dioulasso Burkina Faso Higher Institute of Health Sciences (INSSA) Nazi Boni University (UNB) Bobo-Dioulasso Burkina Faso Pediatric Surgery Service CHUSS Bobo-Dioulasso Burkina Faso Medical Imaging Service CHUSS Bobo-Dioulasso Burkina Faso Anatomical Pathology Service CHU-YO Bobo-Dioulasso Burkina Faso

Background: ovarian tumors in the girl child are sometimes revealed by the development of secondary sexual characteristics. The authors report the case of a five-year-old girl in whom the disease was revealed by early puberty. Case presentation: A five-year-old girl with an enlarged abdomen for about four months. The onset of pain and the sensation of a mass prompted the consultation. The development of secondary sexual characteristics (SSC) noted by the family had not been mentioned. The patient was classified as pubertal stage 2 according to the Tanner classification. An abdominal ultrasound and a CT scan showed a large left ovarian mass, an enlarged uterus for the patient’s age and a normal right ovary. The hormonal workup was not contributive. The treatment consisted only of a left salpingo-ovarectomy, without complementary chemotherapy. Anatomic pathological examination of the surgical specimen concluded to a juvenile tumor of the granulosa. The evolution was good with a beginning of regression of the HSC one month after the ovarectomy. Discussion: Granulosa tumors are sometimes secretory cancers, generally with a low potential for malignancy and therefore a very good prognosis. Surgery based on total adnexectomy is the first-line treatment. The large size of the tumor, the presence of ascites and capsular rupture are factors of poor prognosis, hence the importance of early diagnosis. Conclusion: Routine comprehensive physical examination should be de rigueur for abdominal masses in girls, especially in the context of various beliefs that may impede early referral to care.

关键词： ovarian tumor Juvenile Granulosa tumor Early Puberty Early Diagnosis Surgery

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CLINICAL DIAGNOSIS AND TREATMENT OF SMALL ovarian tumor IN POSTMENOPAUSAL WOMEN

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Chinese Journal of Cancer Research 2006年第3期18卷 229-234页

作者：吴震溟狄文 Department of Obstetrics and Gynecology Renji Hospital Shanghai Jiaotong University Shanghai 200001

Objective： To investigate the clinical symptom, ultrasonographic scan finding, serum CA125 value, histopathological type and treatment of small ovarian tumor （〈5 cm） in postmenopausal women. Methods： Retrospective analysis was carried out for 52 clinical materials of ovarian tumor cases in women more than one year after menopausal between Jan 1997 and Dec 2004. The largest diameter of the ovarian mass is less than 5 cm. Results： There were 11 ovarian cancers and 1 borderline ovarian tumor among 52 small ovarian tumors （23.1%）. 10 ovarian cancers were epithelial neoplasms and 2 were sex cord-stromal tumors, and 8 cases were in late stage according to FIGO staging system （33.3%）. Compared with benign tumor, there is no significant difference in the onset age, interval after menopausal and duration of history. The main clinical feature is abdominal symptoms, such as abdominal pain and distension in the malignant cases. The patients with benign tumors often showed the ovarian mass during the annual screening or admitted into hospital for other causes. The ultrasonography finding and serum CA125 level showed much difference between benign and malignant cases. Unilocular smooth-walled ovarian cysts mostly were found in benign tumor and the CA125 values were always less than 35 U/ml; but the solid or complex sonographic structures （multilocular, or with a papillary projections on the wall） often indicated a high risk of cancer, especially there was ascites in the pelvic cavity. Serum CA125 level in many cancer cases was elevated （〉35 U/ml）, over 300 U/ml in more than half of the patients. Surgery is still the first choice to treat ovarian cancer, and chemotherapy would be an auxiliary method. Till now, 3 ovarian cancer patients died of complications of cancer and 2 cases had recurrence. Conclusion： Small ovarian tumor in postmenopausal women has a comparatively low malignant occurrence but more in later stage. Many are epithelial carcinoma. If there is complex or parenchym

关键词： ovarian tumor Postmenopausal CA125 Ultrasonography

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Detection of Laminin in Serum and Ascites from Patients with Epithelial ovarian tumor

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第1期22卷 58-59,68页

作者：初永丽杨元先林美华王泽华 Department of Obstetrics and Gynecology Xiehe Hospital Tongji Medical College of Huazhong University of science and Technology Wuhan

The change in serum laminin (LN) level and its clinical significance in epithelial ovarian tumor were investigated. The LN levels in serum and ascites samples from 69 patients with epithelial ovarian tumor and 42 cases as control group before and after operation were analyzed by radioimmunoassay. The results showed that the serum LN levels in the patients with malignant tumors (157.85 ±14.37 ng/ml) were significantly higher than that in the control group (125.14 ±7.03 ng/ml) and in the patients with benign tumors (128.36±8.75 ng/ml)(both P tumors was higher than those in moderate differentiated tumors and high differentiated tumors ( P tumors. The serum LN levels in the patients with lymph node metastasis (165.41±19.91 ng/ml) was obviously higher than those without lymph node metastasis (152.35±10.34 ng/ml)( P ovarian tumors, suggesting that LN might be one of important diameters reflecting tumor biological characteristics.

关键词： ovarian tumor laminin radioimmunoassay

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THE MODIFIED RADIOIMMUNOASSAY OF SERUM INHIBIN AND ITS VALUE IN MONITORING ovarian tumor

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Chinese Journal of Cancer Research 1999年第2期11卷 142-146页

作者：隋龙张令浩王成海由振东刘东罗建华金志军朱明伟 Department of Obstetrics and Gynecology Changzheng Hospital Second Military Medical University Shanghai China Department of Neurobiology Second Military Medical University Shanghai China Research Laboratory of Obstetrics and Gynecology Shanghai Medical University Shanghai China

Objectives and Methods: A modified radioimmunoassay (RIA) of serum inhibin (INH) was developed and applied to measure serum INH contents in 39 fertile and 16 postmenopausal women. Thirty-three cases of ovarian tumors, including granulosa cell tumors and other kinds of ovarian tumors, were monitored by serum INH RIA. Results: The mean value of serum INH contents in follicular, peri-ovulatory and mid-luteal phases of fertile women were 9.48±7.10 pg/ml (2.04～18.53pg/ml), 19.04±9.73 pg/ml (3.49～33.26 pg/ml) and 131.13±110.81 pg/ml (3.49～ 341.10 pg/ml), respectively. Serum INH concentration was negatively correlated with serum FSH concentration, (rs=?0.483,Povarian granulosa cell tumor, thecoma, mucinous cystadenocarcinoma and malignant teratoma cases were significantly higher than that of other ovarian tumors, (Povarian granulosa cell tumor, thecoma, mucinous cystadenocaricinoma and endometrioid carcinoma cases with serum CA-125 values in normal range before operation, but serum INH contents decreased to normal range within one week after operation. And consecutive serum INH RIA could be a valuable tool in monitoring for therapeutic effect. Conclusion: Modified INH RIA was of convenient, time-saving and quantitative characteristics, especially with its high sensitivity (ovarian tumor. INH RIA combined with the measurement of serum CA-125 would be helpful to the early diagnosis, treatment and follow-up for ovarian cancer.

关键词： Inhibin ovarian tumor Granulosa cell tumor Radioimmunoassay CA-125

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Construction of Human ScFv Phage Display Library against ovarian tumor

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第5期26卷 497-499页

作者：夏劲松毕昊姚琴屈伸宗义强 Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong Universty of Science and TechnologyWuhan 430030China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In order to construct a single chain fragment variable （ScFv） phage display library against ovarian tumor, by using RT-PCR, the human heavy chain variable region genes （VH） and light chain variable region genes （VL） were amplified from lymphocytes of ovarian tumor patients and subsequently assembled into ScFv genes by SOE. The resulting ScFv genes were electrotransformed into E. coli TG1 and amplified with the co-infection of helper phage M13KO7 to obtain phage display library. The capacity and titer of the resulting library were detected. The phage antibody library with a capacity of approximately 3 × 10^9 cfu/μg was obtained. After amplification with helper phage, the titer of antibody library reached 5 μ 10^12 cfu/mL. Human ScFv library against ovarian tumor was constructed successfully, which laid a foundation for the screening of ovarian tumor specific ScFv for the radioimmunoimaging diagnosis of ovarian tumor.

关键词： ScFv phage display library ovarian tumor SOE radioimmunoimaging

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Endocrine-Disrupting Chemicals: Possible Genesis of ovarian tumors

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1025-1037页

作者： Kasonde Chanda Ziwei Wang Shen Ning Xue Bin Yingxiao Yan Department of Obstetrics and Gynecology Second Affiliated Hospital of Nanjing Medical University Nanjing China Core Laboratory Department of Clinical Laboratory Sir Run Run Hospital Nanjing Medical University Nanjing China China Exposomics Institute (CEI) Precision Medicine Co. Ltd. Shanghai China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing China

Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to several ovarian pathologies. Exposure to endocrine-disrupting chemicals may start at any time of life from the fetal stage to adulthood resulting in various health complications The purpose of our study is to compare the concentration levels and association of benzopyrene, bisphenol A and genistein in patients with ovarian tumors and normal control group. We also sort to evaluate the predictive performance of benzopyrene, bisphenol A and genistein in patients with ovarian tumors. Methods: A case-control study was conducted for randomly selected participants involving 30 patients and 30 controls. 30 patients with radiologically diagnosed and histopathological confirmed ovarian tumors were included in the study between January 2022 and December 2022. Urine samples from each group were analyzed using liquid chromatography-mass spectrometry. Descriptive analysis for normally distributed continuous variables was done accordingly. Concentration levels of endocrine-disrupting chemicals were assessed using the Mann-Whitney test. The association of endocrine-disrupting chemicals with pathological ovarian tumors was analyzed using binary logistic regression. Evaluation of the diagnostic performance of endocrine-disrupting chemicals was analyzed using the ROC curve. Results: Overall, patients were significantly (P = 0.000) older than the healthy controls. Mean years (SD) were 36.7 (7.90) and 28.8 years (4.89) for patients and normal women respectively. Endometriomas had the highest incidence of 50%. The level of benzopyrene and bisphenol A in patients was significantly higher than those in the control group, while the level of genistein was significantly higher in normal controls. Benzopyrene and bisphenol A were significantly associated with ovarian cysts, and the incidence of pathological ovarian cysts was positively correlated to these EDCs, with OR value 64.79 (

关键词： Environmental Toxicants Endocrine-Disrupting Chemical ovarian Cyst ovarian tumor

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MUTATIONAL SCREEN AT THE OEYTS-JEGHERS (LKB1) LOCUS IN SPORDIC COLON AND ovarian tumorS

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Chinese Journal of Cancer Research 2001年第2期13卷 155-156页

作者：王振军严仲瑜万远廉郭彦彦 Ian Tomlinson 徐文怀 Department of Surgery Peking University First Hospital

Objective: To screen LKB1 mutation in sporadic colon and ovarian tumors. Methods: Using PCR-SSCP analysis, 72 colon cancer, 45 ovarian cancer, 14 granulosa cell tumor were screened for LKB1 mutation. Results: no mutation was in sporadic colon and ovarian adenocarcinomas. Two mutations were detected in one of the granulosa cell tumors: a mis-sense mutation affecting the putative start codon (ATG→ACG, MIT); and a silent change in erxon 7 (CTT→CTA, leucine). Conclusion: LKB1 mutations in sporadic colon and ovarian cancers are rare event and LKB1 is not the target gene lost on chromosome 19p13.3 in ovarian cancers.

关键词： LKB1 Colon cancer ovarian tumor

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Clinical Presentation of ovarian tumors

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Open Journal of Obstetrics and Gynecology 2016年第4期6卷 205-209页

作者： Qamarunissa Muhabat Fakharunissa Waheed Waqarunissa Nigar Jabeen Department of Obstetrics & Gynecology Aga Khan Maternity & Child Care Hospital Hyderabad Sindh Pakistan Department of Obstetrics & Gynecology Indus Tando M. Khan Hyderabad Sindh Pakistan Department of Obstetrics &Gynecology Isra University Hospital Hyderabad Sindh Pakistan Department of Obstetrics & Gynecology Aga khan Maternity & Child Care Hospital Hyderabad Sindh Pakistan

ovarian malignancy is a serious disease affecting women of all ages, more so above 50 years, and they are still difficult to treat, partly because no truly effective therapy has yet been developed although presentation is often vague and non-specific, the symptoms are definitely present. It is important to recognize the symptoms so far, there is no test yet available, which is truly specific and suitable for screening and early detection of epithelial ovarian carcinoma. So, it is concluded that for prognosis and patient survival, early detection and treatment is mandatory.

关键词： Ovaries ovarian tumor Clinical Presentation

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Fully Automatic Segmentation of Gynaecological Abnormality Using a New Viola–Jones Model

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Computers, Materials & Continua 2021年第3期66卷 3161-3182页

作者： Ihsan Jasim Hussein M.A.Burhanuddin Mazin Abed Mohammed Mohamed Elhoseny Begonya Garcia-Zapirain Marwah Suliman Maashi Mashael S.Maashi BIOCORE Research Group Universiti Teknikal Malaysia MelakaMelaka76100Malaysia Director of UTeM International Centre BIOCORE Research GroupUniversiti Teknikal Malaysia MelakaMelaka76100Malaysia College of Computer Science and Information Technology University of AnbarRamadi31001Iraq Department of Computer Science College of Computer Information TechnologyAmerican University in the Emirates503000United Arab Emirates eVIDA Laboratory University of DeustoBilbao48007Spain Medical Laboratory Science Department King Abdulaziz UniversityJeddah21589Saudi Arabia Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11451Saudi Arabia

One of the most complex tasks for computer-aided diagnosis(Intelligent decision support system)is the segmentation of ***,this study proposes a new fully automated method for the segmentation of ovarian and breast ultrasound *** main contributions of this research is the development of a novel Viola–James model capable of segmenting the ultrasound images of breast and ovarian cancer *** addition,proposed an approach that can efficiently generate region-of-interest(ROI)and new features that can be used in characterizing lesion *** study uses two databases in training and testing the proposed segmentation *** breast cancer database contains 250 images,while that of the ovarian tumor has 100 images obtained from several hospitals in *** of the experiments showed that the proposed approach demonstrates better performance compared with those of other segmentation methods used for segmenting breast and ovarian ultrasound *** segmentation result of the proposed system compared with the other existing techniques in the breast cancer data set was 78.8%.By contrast,the segmentation result of the proposed system in the ovarian tumor data set was 79.2%.In the classification results,we achieved 95.43%accuracy,92.20%sensitivity,and 97.5%specificity when we used the breast cancer data *** the ovarian tumor data set,we achieved 94.84%accuracy,96.96%sensitivity,and 90.32%specificity.

关键词： Viola-Jones model breast cancer segmentation ovarian tumor ovarian tumor segmentation breast cancer ultrasound images active contour cascade model

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