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osteoporosis treatment:When to Discontinue and When to Re-start

Bone Research 2013年第4期1卷 323-335页

作者： Silvano Adami Luca Idolazzi Elena Fracassi Davide Gatti Maurizio Rossini Rheumatology Unit Universityof Verona

A number of effective therapies for the treatment of osteoporosis have become available in recent years. However, uncertainty exists regarding their long-term use and effectiveness. Bisphosphonate treatment, unlike hormone replacement, denosumab or teriparatide, is associated with benefits extended even after treatment discontinuation. The extended benefits are most apparent for alendronate （ALN） and zoledronate （ZOL）. A drug holiday might be considered in patients compliant with treatment, and who have had a response fractures the decision to consider a drug holiday should treatment. at low-moderate risk and who have been fully to treatment. In patients at low-moderate risk of be balanced also with the safety profile of each

关键词： osteoporosis treatment bisphosphonates duration of osteoporosis treatment

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Dual regulation of osteoclastogenesis and osteogenesis for osteoporosis therapy by iron oxide hydroxyapatite core/shell nanocomposites

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Regenerative Biomaterials 2021年第5期8卷 1-13页

作者： Mengye Li Shengxiang Fu Zhongyuan Cai Danyang Li Li Liu Di Deng Rongrong Jin Hua Ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China

osteoporosis is a skeletal disorder resulted in significant structural and functional changes,arousing a wide concern for the high prevalence and *** between osteoclastogenesis and osteogenesis have been verified as a main pathology etiology and considered an efficient therapy target in both clinical and pre-clinical *** recent years,inorganic nanomaterials have shown provable activities on osteoclastogenesis inhibition and osteogenesis promotion,***,in this study,a class of hydroxyapatite coated superparamagnetic iron oxide nanoparticles(SPIO@HA)were developed with a coreshell structure for targeting both osteoclastogenesis and *** optimal ratio of SPIO@15HA(Fe/Ca¼1:15,mol/mol)was screened to obtain dual function for inducing both bone formation and preventing bone *** obtained nanocomposites significantly prevented the bone loss of ovariectomized(OVX)mice and increased bone mineral density(BMD)by 9.4%,exhibiting high bone accumulation in magnetic resonance imaging evaluation and reasonable biosafety *** mechanism study revealed that SPIO@15HA can suppress bone marrow monocyte derived osteoclast differentiation through TRAF6p62CYLD signaling complex ***,it could activate MSC osteogenic differentiation by TGF-b,PI3K-AKT and calcium signaling pathway ***,incubation of SPIO@15HA with MSC resulted in several cytokines overexpression such as osteoprotegerin(OPG),CSF2,CCL2 etc.,which are responsible for maintaining the bone remodeling *** dual function of as-prepared SPIO@15HA may find a new way for designing of inorganic components containing core/shell nanomaterials for osteoporosis treatment.

关键词： hydroxyapatite superparamagnetic iron oxide osteoporosis treatment nanocomposites

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