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Crosstalk between bone and other organs

Medical Review 2022年第4期2卷 331-348页

作者： Wanqiong Yuan Chunli Song Department of Orthopedics Peking University Third HospitalBeijingChina Beijing Key Laboratory of Spinal Disease BeijingChina Engineering Research Center of Bone and Joint Precision Medicine BeijingChina Department of Orthopedics Peking University Third HospitalNo.49North Garden RoadHaidian DistrictBeijing 100919China

Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus,traditionally.Recently,further study of bone has revealed additional functions as an endocrine organ connecting systemic organs of the whole body.Communication between bone and other organs participates in most physiological and pathological events and is responsible for the maintenance of homeostasis.Here,we present an overview of the crosstalk between bone and other organs.Furthermore,we describe the factors mediating the cross-talk and review the mechanisms in the development of potential associated diseases.These connections shed new light on the pathogenesis of systemic diseases and provide novel potential targets for the treatment of systemic diseases.

关键词： bone crosstalk endocrine organs osteocalcin osteokines receptor activator for nuclear factor-κB ligand

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Exercise-Dependent Modulation of Bone Metabolism and Bone Endocrine Function:New Findings and Therapeutic Perspectives

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Journal of Science in Sport and Exercise 2019年第1期1卷 20-28页

作者： Giovanni Lombardi IRCCS Istituto Ortopedico Galeazzi Laboratory of Experimental Biochemistry and Molecular BiologyVia Riccardo Galeazzi420161 MilanItaly Department of Physiology and Pharmacology Gdańsk University of Physical Education and SportKazimierza Górskiego 180-336 GdańskPomorskiePoland

Physical inactivity is the fourth leading cause of mortality worldwide;regardless of geographic location and income,it is a contributing risk factor to the other three causes.Physical activity is really a drug,a poly-pill;its“regular use”can reduce this risk throughout the activation of a plethora of responses in virtually all the body tissues.The beneficial effects of physi-cal activity on cardiovascular function and hemodynamics are mainly mediated by skeletal muscle,adipose tissue and the immune system via the usage,delivery and distribution of metabolic substrates and improvement in inflammatory status.There is emerging evidence for exercise-dependent changes in bone metabolism as well;with improved bone quality,reduced fracture risk and increased bone endocrine function,the last of which modulates energy metabolism through its effects on pancreatic islet cells,skeletal muscle and adipose tissue.Bone endocrine function relies on the integration of biomechani-cal stimuli and endocrine signals from other organs and tissues.Here I review current concepts about exercise-dependent modulation of bone endocrine function and its beneficial effects on whole-body metabolism.Several molecular mechanisms have been identified that support this exercise-stimulated bone-mediated metabolic effect and,among these,Wnt signaling,fibroblast growth factor-23,bone morphogenic protein-7,osteocalcin,RANK/RANKL/OPG axis,and lipocalin-2 gave the largest evidences.In conclusion,beside the controversies surrounding technical aspects of the exercise,the efficacy of physi-cal activity in preventing/treating metabolic and inflammatory dysfunctions also passes throughout the bone.

关键词： Bone metabolism Bone endocrine function osteokines Biomechanical loading

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