检索结果-南通市图书馆

osteoimmunology in bone malignancies:a symphony with evil

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of the National Cancer Center

Journal of the National Cancer Center 2024年第4期4卷 354-368页

作者： Churui Song Tie Tong Biqi Dai Yue Zhu Elina Chen Min Zhang Weijie Zhang Department of Breast Surgery and Oncology Cancer Institutethe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Life Sciences Institute Zhejiang UniversityHangzhouChina College of Natural Sciences University of Texas at Austin110 Inner Campus DriveAustinUSA Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology Life Sciences Instituteand Department of Orthopaedic Surgerythe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina

Bone marrow is pivotal for normal hematopoiesis and immune responses,yet it is often compromised by *** bone microenvironment(BME),composed of bone and immune cells,maintains skeletal integrity and blood *** emergence of primary or metastatic tumors in the skeletal system results in severe complications and contributes significantly to cancer-related *** tumors set offa series of interac-tions among cancer,bone,and immune cells,and disrupt the BME locally or ***,the drivers,participants,and underlying molecules of these interactions are not fully *** review explores the crosstalk between bone metabolism and immune responses,synthesizing current knowledge on the intersection of cancer and osteoimmune *** outlines how bone marrow immune cells can either facilitate or hinder tumor progression by interacting with bone cells and pinpoints the molecules responsible for immunosuppression within bone ***,it discusses how primary tumors remotely alter the BME,leading to systemic immune suppression in cancer *** knowledge provides critical rationales for emerging immunotherapies in the treatment of bone-related *** together,by summarizing the intricate relationship between tumor cells and the BME,this review aims to deepen the understanding of the diversity,complexity,and dynamics at play during bone tumor ***,it highlights the potential of targeting bone-tumor interactions to correct aberrant immune functions,thereby inhibiting tumor growth and metastasis.

关键词： Bone metastasis Osteosarcoma osteoimmunology Bone microenvironment Immunotherapies

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第11期6卷 4014-4026页

作者： Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Key Laboratory for Organic Electronics&Information Displays(KLOEID) Institute of Advanced Materials(IAM)and School of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210000China

The treatment of large-area bone defects still faces many difficulties and ***,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone *** clot gel platform as natural biomaterials can be engineered from autologous *** implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different ***,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and *** find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser *** further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease *** to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation.

关键词： Blood clot BMP-2 osteoimmunology Photothermal therapy Bone repair

osteoimmunology research in rheumatoid arthritis:From single-cell omics approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第14期136卷 1642-1652页

作者： Nan Hu Jing Wang Bomiao Ju Yuanyuan Li Ping Fan Xinxin Jin Xiaomin Kang Shufang Wu Department of Rheumatology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Center for Translational Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China

Cellular immune responses as well as generalized and periarticular bone loss are the key pathogenic features of rheumatoid arthritis(RA).Under the pathological conditions of RA,dysregulated inflammation and immune processes tightly interact with skeletal system,resulting in pathological bone damage via inhibition of bone formation or induction of bone *** omics technologies are revolutionary tools in the field of modern biological *** enable the display of the state and function of cells in various environments from a single-cell resolution,thus making it conducive to identify the dysregulated molecular mechanisms of bone destruction in RA as well as the discovery of potential therapeutic targets and ***,we summarize the latest findings of single-cell omics technologies in osteoimmunology research in *** results suggest that single-cell omics have made significant contributions to transcriptomics and dynamics of specific cells involved in bone remodeling,providing a new direction for our understanding of cellular heterogeneity in the study of osteoimmunology in RA.

关键词： Rheumatoid arthritis osteoimmunology Single-cell omics Single-cell RNA sequencing scATAC-seq

Degradation particles derived from high-purity magnesium inhibit osteogenic differentiation through regulation of macrophage polarization

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第8期139卷 113-119页

作者： Yu Sun Han Yu Hongzhou Peng Xinbao Kang Zhaoxiang Peng Xieping Dong Wenhui Wang Yang Song Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Orthopaedic Surgery Ningbo Medical Treatment Center Lihuili HospitalNingbo 315040China Department of Orthopaedic Surgery Jiangxi People’s HospitalNanchang 330006China Suzhou Origin Medical Technology Co.Ltd. Jiangsu 215513China

Magnesium(Mg)and its alloys have great potential as orthopedic implant candidates,which could release various bioactive substances during *** particles(DPs)are one of the degradation products,but the osteoimmunology effects are still *** this study,the effect of DPs on the polar-ization of macrophages and their release of cytokines was *** results verify that excessive generation of DPs from biodegradable Mg can induce macrophages to realize polarization of proinflamma-tory M1 ***,macrophages secrete proinflammatory cytokines to inhibit the osteogenic differentiation of rat bone marrow stem cells(rBMSCs).This suggests that the effects of DPs should be considered when evaluating Mg-based *** continuously produced with the degradation of Mg-based implants may influence osseointegration.

关键词： Magnesium Degradation particles Macrophage Phagocytosis osteoimmunology

Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第3期3卷 134-147页

作者： Caiyao Hou Yujue Zhang Zhaoyong Lv Yurun Luan Jun Li Chunxiu Meng Kun Liu Xin Luo Liyu Chen Fengzhen Liu Department of Materials Science and Engineering Liaocheng UniversityLiaocheng 252000China Liaocheng People's Hospital Liaocheng Hospital Affliated Shandong First Medical UniversityLiaocheng 252000China The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250023China

In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication *** play a central role in mediating immune osteogenesis,exosomes derived from them have osteogenic regulation and can be used as cariers in bone tissue ***,there are problems with exosomal therapy alone,such as poor targeting,and the content of loaded molecules cannot reach the therapeutic *** this study,macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone ***3T3-E1 cells were incubated with the culture supermatants of Mo,M1 and M2 macrophages,and it was found that the culture medium of M2 macrophages had the most significant effects in contributing to ***-throughput sequencing identified that miR-365-2-5p was significantly expressed in exosomes derived from M2 *** incubated MC3T3-E1 with exosomes overexpressing or kmocking down miR-365-2-5p to examine the biological function of exosome miR-365-2-5p on MC3T3-E1 *** findings suggested that miR-365-2-5p secreted by exosomes increased the osteogenesis of ***,miR-365-2-5p had a direct influence over osteogenesis for *** analysis combined with dual luciferase detection indicated that miR-365-2-5p binded to the 3'-UTR of *** summary,exosomes secreted by M2 macrophages targeted OLFML1 through miR-365-2-5p to facilitate osteogenesis.

关键词： macrophage exosomes osteogenesis osteoimmunology

Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第4期22卷 404-422页

作者： Jia Li Congrui Zhao Yangbo Xu Lu Song Yanqi Chen Yuzi Xu Yang Ma Siyuan Wang Antian Xu Fuming He Department of Prosthodontics Stomatology HospitalSchool of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhouChina

Osseointegration seems to be a foreign body reaction equilibrium due to the complicated interactions between the immune and skeletal *** heterogeneity of the osteoimmune microenvironment in the osseointegration of implant materials remains ***,a single-cell study involving 40043 cells is conducted,and a total of 10 distinct cell clusters are identified from five different groups.A preliminary description of the osteoimmune microenvironment revealed the diverse cellular heterogeneity and dynamic changes modulated by implant *** increased immature neutrophils,Ly6C+CCR2hi monocytes,and S100a8hi macrophages induce an aggressive inflammatory response and eventually lead to the formation of fibrous capsule around the stainless steel *** enrichment of mature neutrophils,FcgR1hi and differentiated immunomodulatory macrophages around the titanium implant indicates favorable osseointegration under moderate immune ***-depletion mice are conducted to explore the role of neutrophils in *** may improve bone formation by enhancing the recruitment of BMSCs via the CXCL12/CXCR3 signal *** findings contribute to a better knowledge of osteoimmunology and are valuable for the design and modification of‘osteoimmune-smart’biomaterials in the bone regeneration field.

关键词： osteoimmunology Neutrophil Implant Osseointegration Single-cell transcriptomics

Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2022年第1期9卷 107-118页

作者： Xingdan Liu Liping Ouyang Lan Chen Yuqin Qiao Xiaohan Ma Guohua Xu Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesDingxi Road 1295Shanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesYuquan Road 19Beijing 100049China Tongren Hospital Shanghai Jiao Tong University School of Medicine1111 Xianxia RoadShanghai 200336China School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education)Zhengzhou UniversityScience Avenue 100Zhengzhou 450001China Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesWenwei Road 345Ningbo 315300China Department of Orthopedic Surgery Spine CenterChangzheng HospitalNaval Medical UniversityNo.415 Fengyang RoadShanghai 200003China

The adverse immune response mediated by macrophages is one of the main factors that are prone to lead poor osseointegration of polyetheretherketone(PEEK)implants in ***,endowing PEEK with immunomodulatory ability to avoid the adverse immune response becomes a promising strategy to promote bone *** this work,sulfonation and hydrothermal treatment were used to fabricate a 3D porous surface on PEEK and hydroxyapatite(HA)composited *** HA composited PEEK with 3D porous surface inhibited macrophages polarizing to M1 phenotype and downregulated inducible nitric oxide synthase protein expression,which led to a nitric oxide concentration reduction in culture medium of mouse bone marrow mesenchymal stem cells(mBMSCs)under coculture *** decrease of nitric oxide concentration could help to increase bone formation-related OSX and ALP genes expressions and decrease bone resorption-related MMP-9 and MMP-13 genes expressions via cAMP–PKA–RUNX2 pathway in *** summary,the HA composited PEEK with 3D porous surface has the potential to promote osteogenesis of PEEK through immunomodulation,which provides a promising strategy to improve the bone repair ability of PEEK.

关键词： polyetheretherketone three-dimensional porous hydroxyapatite osteoimmunology nitric oxide

Engineered extracellular vesicles:Regulating the crosstalk between the skeleton and immune system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered Regeneration 2022年第3期3卷 270-282页

作者： Wei-Wei Yu Qian-Qian Wan Yu Wei Yu-Tao Li Qi-Hong Li Tao Ye Ke-Hui Xu Jing-Han Song Chen Lei Mei-Chen Wan Kai Jiao Franklin R Tay Li-Na Niu State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of Stomatologythe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Stomatology the Fifth Medical CentreChinese PLA General HospitalDongda StreetBeijing 100071China The Dental College of Georgia Augusta UniversityAugustaGeorgiaUnited States

osteoimmunology has gained momentum in recent years,focusing on the crosstalk between the skeleton and the immune *** vesicles(EVs)are nanoscale vesicles that are potential candidates for cell-free tissue regeneration *** may be used for repairing damaged tissues and regulating the body’s immune system and bone-related metabolic *** of the ability of EVs to deliver bioactive signals and mediate intercellular communication,they can decipher the complex mechanisms of interaction within the“osteoimmune system”at the molecular *** address the lack of targeting ability caused by vesicle heterogeneity in the clinical applications of EVs,these nanoscopical entities may be modified by bioengineering techniques to optimize the interaction between bone repair and immunomodulation for improving treatment efficacy,specificity and *** the present review,the endogenous properties that make EVs natural delivery agents are *** that may be improved by bioengineering are *** therapeutic applications of EVs in the rehabilitation of bone defects are *** opportunities and challenges that need to be addressed for translating this field of research into clinical practice are brought into perspectives.

关键词： Bone defect Crosstalk Engineered extracellular vesicles Immune regulation osteoimmunology

Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第1期6卷 191-207页

作者： Lan Chen Donghui Wang Jiajun Qiu Xianming Zhang Xingdan Liu Yuqin Qiao Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024China

Ds-block elements have been gaining increasing attention in the field of biomaterials modification,owing to their excellent biological properties,such as antibiosis,osteogenesis,***,their function mechanisms are not well understood and conflicting conclusions were drawn by previous studies on this issue,which are mainly resulted from the inconsistent experimental *** this work,three most widely used ds-block elements,copper,zinc,and silver were introduced on titanium substrate by plasma immersion ion implantation method to investigate the rule of ds-block elements in the immune *** showed that the implanted samples could decrease the inflammatory responses compared with Ti *** trend of anti-inflammatory effects of macrophages on samples was in correlation with cellular ROS levels,which was induced by the implanted biomaterials and positively correlated with the number of valence electrons of ds-block *** co-culture experiments of macrophages and bone marrow mesenchymal stem cells showed that these two kinds of cells could enhance the anti-inflammation and osteogenesis of samples by the paracrine manner of *** general,in their steady states on titanium substrate(Cu2+,Zn2+,Ag),the ds-block elements with more valence electrons exhibit better anti-inflammatory and osteogenic ***,molecular biology experiments indicate that the PGE2-related signaling pathway may contribute to the desired immunoregulation and osteoinduction capability of ds-block *** findings suggest a correlation between the number of valence electrons of ds-block elements and the relevant biological responses,which provides new insight into the selection of implanted ions and surface design of biomaterials.

关键词： Ds-block element Valence electron Immune response osteoimmunology Molecular mechanism