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Discovery of Aquaporin-3 as a sperm protein essential for postcopulatory sperm osmoadaptation

Discovery of Aquaporin-3 as a sperm protein essential for po...

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“细胞活动生命活力”——中国细胞生物学学会全体会员代...

作者： Qi Chen~(1,2,*),Hongying Peng~(1,*),Li Lei~(1,2,*),Ying Zhang~(1,2),Haibin Kuang~(1,2),Yujing Cao~1,Qi-xian Shi~3, Tonghui Ma~4,Enkui Duan~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China 2.Graduate School of Chinese Academy of Sciences,Beijing 100049,China 3.Unit of Reproductive Physiology,Zhcjiang Academy of Medical Sciences,Hangzhou 310013,China 4.Central Research Laboratory,Bethune Second Hospital of Jilin University,265 Ziqiang Street,Changchun 130041,China.

In the journey from the male to female reproductive tract,mammalian sperm experience a natural osmotic decrease(e.g.,in mouse,from～415 mOsm in the cauda epididymis to～310 mOsm in the uterine cavity).At one hand,the hypotonic stress upon ejaculation is beneficial for mouse sperm motility "start-up"(evolutionary trait from fish sperm);However,the hypotonic stress could also cause potential harms to sperm function by inducing un-wanted cell *** counteract this negative impact, mammalian sperm have acquired mechanisms to drive rapid transmembrane water movement for efficient cell volume *** physiological and pharmacological studies have shown that ion channel-controlled water influx/efflux is actively involved in the process of sperm volume regulation;however,no specific sperm proteins have been found responsible for this rapid *** this study,we demonstrated that aquaporin3(AQP3) is localized in sperm tail membrane of mice and humans. Aqp3-deficient sperm show normal motility activation in response to hypotonicity but display increased vulnerability to hypotonic cell swelling,characterized by increased tail bending after entering *** sperm defect is a result of impaired sperm volume regulation and progressive cell swelling in response to physiological hypotonic stress during male-female reproductive tract ***-lapse imaging revealed that the cell volume expansion begins at cytoplasmic droplet,forcing the tail to angulate and form a hairpin-like structure due to mechanical membrane *** tail deformation hampered sperm migration into oviduct,resulting in impaired fertilization and reduced male *** data revealed AQP3 as an essential membrane pathway for sperm regulatory volume decrease(RVD) upon physiological hypotonicity,balancing the "trade-off’ between hypotonic induced sperm motility and cell swelling, thereby optimizing postcopulatory sperm *** the similar expression pattern of AQP3

关键词： aquaporin-3(AQP3) sperm osmoadaptation regulatory volume decrease(RVD) mechanosensing

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