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Different effects of orexin-A on AMPA receptor-mediated currents of on- and off-type ganglion cells in rat retina

Different effects of orexin-A on AMPA receptor-mediated curr...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Chao ZHENG,Fei LIU,Xiong-Li YANG~*,Yong-Mei ZHONG~* Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Objective Two novel neuropeptides,orexin-A and orexin-B,are identified as endogenous ligands of two orphan G-protein-coupled receptors:orexin 1 and orexin 2 receptors(OXR and OXR).This neuropeptide system is involved in a variety of physiological processes,such as sleep/wake regulation,feeding behaviors *** most of the mammalian suprachiasmatic nucleus(SCN) circadian clock is photoentrained by photic signals from the retina through the retinohypothalamic tract,little is known about the distribution and function of orexins in *** purpose of this study is to investigate how orexins and OXRs are expressed in the rat retina and how orexin-A modulates AMPA receptors in retinal ganglion cells(GCs).Methods Western blot analysis and immunocytochemistry were used to explore the distribution of orexins and OXRs in rat *** of orexin-A on AMPA receptor-mediated currents were investigated in freshly dissociated GCs by whole cell patchclamp recording *** By immunocytochemistry,we show that orexin-A and orexin-B are strongly expressed in horizontal,bipolar,amacrine cells(ACs) and ***,OXR immunoreactivity is observed in most of GCs and all dopaminergic ACs,as well as in both outer and inner plexiform *** contrast,no obvious OXR immunostaining is detectable in the rat *** patch-clamp whole-cell recording,we first characterized AMPA receptor-mediated currents of ***,we found that 100 nM orexin-A suppressed AMPA-induced currents in 53 out of 59 OFF-type GCs *** average,following the perfusion of 100 nM orexin-A,the AMPAinduced currents were reduced to 62.0±2.1%of control(P 1).In contrast,100 nM orexin-A increased AMPAinduced currents in 11 out of 14 ON-type GCs to 153.7±8.5%of control(P 1).The effects of orexin-A were completely blocked by TCS1102,an antagonist for both OXR and OXR(n = 7).In most of ON- and OFF-GCs,the effects of orexin-A were eliminated by SB334867,a selective OXR antagoni

关键词： orexin-A orexin 1 receptor AMPA receptor neurotransmission retina ganglion cells

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orexin excites airway vagal preganglionic neurons in ventral medulla in rat

Orexin excites airway vagal preganglionic neurons in ventral...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：王继江陈咏华葛登云闫先侠郭玉红复旦大学上海医学院生理与病理生理系

Airway functions are under the control of the vagus nerve which centrally originates from airway-related vagal preganglionic neurons(AVPNs)in the nucleus ambiguus(NA)and the dorsal motor nucleus of the vagus(DMV)in medulla *** AVPNs may be regulated by orexin,a peptide produced by hypothalamic neurons and proved to regulate multiple physiological functions including *** this study,we investigated 1)the expression of orexin receptors in the AVPNs which were retrogradely labeled by fluorescent injected into the trachea wall;2)the effect of orexin on the AVPNs in brainstem slices using patch-clamp techniques;3)the physiological effects of centrally administrated orexin in anesthetized *** found that the AVPNs in the NA were stained for orexin 1 receptors;bath application of orexin-A increased the excitability of AVPNs and enhanced the synaptic inputs of AVPNs,including glutamatergic,GABAergic and glycinergic transmissions;central administration of orexin-A into the cisterna magna of juvenile rats produced a significant increase in airway resistance(RL and Re)and a significant decrease in dynamic compliance(Cdyn).These results indicate that orexin regulates the activities of AVPNs and have a role in the control of airway functions.

关键词： orexin airway vagal preganglionic neuron orexin 1 receptor synaptic transmission airway resistance

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