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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

International Journal of oral Science 2013年第2期5卷 92-97页

作者： Abdullah Seckin Ertugrul Ugur Arslan Recep Dursun Sema Sezgin Hakki Department of Periodontology Faculty of DentistryYuzuncu Yil University Department of Microbiology Selcuklu Medical FacultySelcuk University Department of Dermatology Baskent Research Hospital Department of Periodontology Faculty of DentistrySelcuk University

oral lichen planus （OLP） is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms （Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 （18 chronic periodontitis （OLPP） and 9 gingivitis （OLPG）） patients diagnosed with OLP along with 26 （13 chronic periodontitis （HP） and 13 gingivitis （HG）） healthy non-OLP patients. The multiplex polymerase chain reaction （PCR）with subsequent reverse hybridization method （micro-IDent） was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients （OLPG and OLPP） were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients （HG and HP）, these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens＇ percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathoRenic microorganisms in the progress of periodontal diseases of OLP.

关键词： Aggregatibacter actinomycetemcomitans oral lichen planus Porphyromonas gingivalis Prevotel/a intermedia Tannerel/a forsythia Treponema denticola

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The Prevalence of Hepatitis C Virus Infection in oral lichen planus in an Ethnic Chinese Cohort of 232 Patients

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International Journal of oral Science 2010年第2期2卷 90-97页

作者： Yu Zhou Lu Jiang Jie Liu Xin Zeng Qian-ming Chen State Key Laboratory of oral Diseases West China College of Stomatology Sichuan University Chengdu China Section of oral Biology College of Dentistry the Ohio State University Columbus USA

Aim oral lichen planush （OLP） is a chronic inflammatory disease, and has been reported to have a correlation with hepatitis Cvirus （HCV） infection in some regional investigations. In this study, we investigated the prevalence of HCV in patients with oral lichen planus in an ethnic Chinese cohort. Methodology The antibody of HCV infection was detected by using enzymelinked immunosorbent assay. Moreover, the clinical characteristics of whole the cohort have also been studied, such as the gender, age, clinical type, habits and social factors. Results Of all 232 patients, the antibody of HCV infection was detected positive in 4 patients （1.72%） using enzyme-linked immunosorbent assay. It was lower than that in control group of 2.5%, but not significant （P=0.309）. The positive rate of HCV antibody in the erosive type ones （4.2%） was higher than that in the reticular type ones （1.0%）, but this difference was proved to be not significant （P=0.389）. The clinical characteristics of whole cohort, such as the gender, age, clinical type, habits and social factors, showed the outcome obtained in the present study were similar to thao of our previous study. Conclusion HCV may play no etiological role in oral lichen planus in ethnic Chinese OLP patients.

关键词： hepatitis Cvirus oral lichen planus epidemiology Chinese cohort

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Implications of Th1 and Th17 Cells in Pathogenesis of oral lichen planus

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第3期32卷 451-457页

作者：谢三祥丁蕾熊志刚朱声荣 Department of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

oral lichen planus （OLP） is considered a T cell-mediated autoimmune disease with unknown aetiology. T helper cells appear to play an important role in the pathogenesis of OLP. We investigated the possible role of T helper cells, Th1 and Th17, in the lesions and circulation of patients with OLP. Forty patients with OLP and 15 healthy volunteers were recruited. Double immunofluorescence staining was used to detect Th1 and Th17 cells in the OLP lesions, and intracellular cytokine staining and flow cytometry to evaluate the proportion of Th1 and Th17 cells in peripheral blood. The levels of serum interferon （IFN）-γ and interleukin （IL）-17 were assessed by using an enzyme-linked immunosorbent assay. It was found that Th17 cells, as well as Th1 cells, were present in OLP lesions. The proportion of peripheral Th1 and Th17 cells was significantly increased in patients with OLP. The proportion of Th17 cells in atrophic-erosive OLP was elevated as compared with that in reticular OLP. Serum IL-17 levels in OLP patients were significantly higher than in controls, and those in the atrophic-erosive OLP group were increased as compared with the reticular OLP group. However, the levels of serum IFN-γ were slightly decreased in OLP patients. Our data suggested that Th1 and Th17 cells in the local lesions and peripheral blood may be associated with the pathogenesis of OLP, and that IL-17 may be an important proinflammatory cytokine in OLP. These findings enhance our understanding of OLP pathogenesis.

关键词： interferon-γ interleukin-17 oral lichen planus Th1 Th17

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Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus

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International Journal of oral Science 2014年第1期6卷 22-26页

作者： Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen College of Stomatology Chongqing Medical University Chongqing Research Center for oral Diseases and Biomedical Science State Key Laboratory of oral Diseases West China Hospital of Stomatology Sichuan University

Our previous salivary study had demonstrated an apparent T helper 2 （Th2）-predominance in saliva of oral lichen planus （OLP） patients and suggested a potential of salivary interleukin-4 （IL-4） as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-γ （IFN-γ） and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP （40 of the erythematous/ulcerative form and 20 of the reticular form） were recruited for this study, with 40 age-sex-matched healthy volunteers as control group. IFN-γ and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-γ/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-γ and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine- predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP.

关键词： oral lichen planus saliva serum T helper cytokines

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Predicting the Activity of oral lichen planus with Glycolysis-related Molecules:A Scikit-learn-based Function

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Current Medical Science 2023年第3期43卷 602-608页

作者： Yan YANG Pei HU Su-rong CHEN Wei-wei WU Pan CHEN Shi-wen WANG Jing-zhi MA Jing-yu HU Department of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T *** metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic *** present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring *** Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was *** The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy ***,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)*** glycolysis-related molecules were positively correlated to the RAE *** these,LAC had a strong *** univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more *** It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present *** intervention of the glycolytic pathway may provide a potential therapeutic strategy.

关键词： oral lichen planus glycolysis lactic acid linear regression machine learning

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Dysregulation of Notch signaling related genes in oral lichen planus

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 666-669页

作者： Nunthawan Nowwarote Thanaphum Osathanon Mineralized Tissue Research Unit Faculty of Dentistry Chulalongkorn University Bangkok 10330 Thailand Department of Anatomy Faculty of Dentistry Chulalongkorn University Bangkok 10330 Thailand Craniofacial Genetics and Stem Cells Research Group Faculty of Dentistry Chulalongkorn University Bangkok 10330 Thailand

Objective: To investigate a dysregulation of Notch signaling in oral lichen planus(OLP)using public available microarray ***: A m RNA expression profiling dataset from Gene Expression Omnibus was downloaded. Differential gene expression between OLP and normal oral epithelium was examined using Network Analyst. The dysregulated genes related to Notch signaling were ***: Thirteen genes in Notch signaling pathway were significantly differential expressed between OLP and normal epithelium. OLP samples significantly increased the m RNA levels of HEYL, APH1 B, CNTN1 and PSEN2. Whilst, ITCH, HES1, TLE2, DLK2,DTX2, NOTCH3, JAG2, RFNG, and SPEN were downregulated in OLP ***: Notch signaling was dysregulated and may participate in pathophysiologic process in OLP.

关键词： Notch signaling oral lichen planus Expression analysis Genes

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Detection of microRNA expressions in tissues and exfoliative cells reveals the potential role of miR-203 in oral lichen planus

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Journal of Chinese Pharmaceutical Sciences 2014年第5期23卷 279-286页

作者：冯震东史闻蔡志刚华红周德敏北京大学医学部天然药物及仿生药物国家重点实验室药学院化学生物学系北京100191 北京大学口腔医学院北京100191

oral lichen planus （OLP） is a chronic inflammatory disorder and premalignantlesion, of which the mechanisms are still obscure. In the present study, the expression levels of miR-96/182/183 cluster, miR-203, miR-375, and miR-769-5p in both tissues and exfoliative cells of OLP patients as well as healthy volunteers were detected, differentially expressed miRNAs were identified and their correlation with OLP was evaluated by a biplot method. Experimental results show that miR-203 is significantly up-regulated in patient lesion tissues in comparison to volunteer mucosa tissues. Moreover, the contra- dictory insignificant expression changes of miR-203 as well as miR-96/182/183 cluster in comparisons of exfoliative cell samples suggest that different cell compositions in OLP lesion have distinct miRNA regulation, which accords with the histological heterogeneity of OLP. Finally, biplot analyses indicate the expression of miR-203 and miR-96/182/183 cluster are positively correlated in patient lesions. These results provide miR-203 as a molecular indicator of heterogeneity of OLP, and also a potential diagnostic biomarker or therapeutic target that deserves further studies.

关键词： oral lichen planus microRNA RT-qPCR Biplot method miR-203

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Semaphorin 4D-plexin-B2 signal orchestrates CD8+ T cell proliferation and activation in the pathogenesis of oral lichen planus

Semaphorin 4D-plexin-B2 signal orchestrates CD8+ T cell prol...

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第十二届全国免疫学学术大会

作者： Ke yao Shen Shengxian Qiao Hongjiang Liu Qing Wang Gang Department of oral Medicine School of StomatologyFourth Military Medical University Department of Dermatology Xijing HospitalFourth Military Medical University

oral lichen planus(OLP) is among the most common T cell-mediated autoimmune disorders in oral *** only T cells infiltration is a distinguishing histopathologic feature of OLP,but cytotoxic T lymphocyte(CTL)-mediated apoptosis of basal keratinocyte is believed largely responsible for the ultimate pathological change in ***,litter is known about the mechanism that accounts for the modulation of CD8 T cell proliferation and activation in OLP *** 4 D(Sema4 D/CD100) is constitutively expressed on T cells and plays important roles in T cell functions,but its implication relative to immune regulation in OLP remains *** we demonstrated that CD 100 and its ligand plexin-B2 were abundantly expressed on CD8 T cells in OLP *** vitro,incubation with anti-CD3 antibody significantly boosted the expression of plexin-B2,but not CD72 or plexin-Bl on patient-derived CD8 T cells,compared with that on healthy-derived CD8 T ***,the surface expression pattern of plexin-B2 was rightly correlated with the status of CD8T cell ***,adding anti-plexin-B2 or anti-Sema4 D antibody into the patient-derived CD8 T cells after anti-CD3 antibody treatment sufficiently attenuated CD8 T cell augmentation and the production of granzyme ***,this effect was not replicated in CD8T cells isolated from healthy individuals,indicating Sema4 D-plexin-B2-facilitated T cell regulation probably a pathogenical rather than a physiological *** findings may provide a new insight into the pathogenesis of CTL-mediated tissue-specific autoimmune diseases.

关键词： cytotoxic T lymphocyte CD100 plexin-B2 CD8+ T cells oral lichen planus

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Photodynamic therapy of oral leukoplakia and orallichen planus using methylene blue:A pilot study

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 95-105页

作者： Savarimuthu Wilfred Prasanna Ekta Ingle Prakasa Rao Aruna Chidambaranathan Pravada Dornadula Koteeswaran S.Ganesan Department of Medical Physics Anna University Chennai-600025India Department of oral Medicine and Radiology Meenakshi Ammal Dental College Maduravoyal Chennai-600095India Department of oral Medicine and Radiology Sathyabama University Dental College Chennai-600119India

Premalignant lesions like oral lichen planus(OLP),oral leukoplakia(OL)has a fair probability of transforming into malignancy and they are perverse toward conventional ***-namic therapy(PDT)has been considered as an alternative/complimentary therapeutic mo-dality for the management of premalignant *** this study,methylene blue mediated photodynamic therapy(MB-PDT)was used as a possible alternative method for the treatment of OLP and OL.A total of 15 OLP lesions and 13 OL lesions were enrolled in the *** patients were irradiated 1using metal halide lamp filtered at 630土10nm,with a light exposure dose of 120 J/cm^(2) per *** the OLP lesions,MB-PDT was performed once a week for four weeks and for the OL lesions,MB-PDT was performed twice a week for three *** were evaluated pre-and post-and at follow-u sessions by changes in sign and symptom scores,and size of *** have observed a 53.3%of complete reduction in the treated OLP lesions and their decrease in size,sign and symptom score after treatment and at follow-up session was statistially *** have also observed complete response for one OL lesion of the 13 treated *** result indicates that MB-PDT is an effective modality in management of OLP and *** the two types of premalignancies treated with MB-PDT,OLP lesions responded much better than that of OL.

关键词： Photodynamic therapy methylene blue oral lichen planus oral leukoplakia

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oral manifestations of hepatitis C virus infection

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World Journal of Gastroenterology 2014年第24期20卷 7534-7543页

作者： Marco Carrozzo Kara Scally Centre for oral Health Research Oral Medicine DepartmentUniversity of Newcastle upon TyneNewcastle upon Tyne NE2 4BWUnited Kingdom

Extrahepatic manifestations (EHMs) of hepatitis C virus (HCV) infection can affect a variety of organ systems with significant morbidity and mortality. Some of the most frequently reported EHM of HCV infection, involve the oral region predominantly or exclusively. oral lichen planus (OLP) is a chronic inflammatory condition that is potentially malignant and represents cell-mediated reaction to a variety of extrinsic antigens, altered self-antigens, or super antigens. Robust epidemiological evidence support the link between OLP and HCV. As the virus may replicate in the oral mucosa and attract HCV-specific T lymphocytes, HCV may be implicated in OLP pathogenesis. Sjögren syndrome (SjS) is an autoimmune exocrinopathy, characterized by dryness of the mouth and eyes and a multitude of other systemic signs and symptoms. SjS patients have also an increased risk of non-Hodgkin lymphoma. Patients with chronic hepatitis C do frequently have histological signs of Sjögren-like sialadenitis with mild or even absent clinical symptoms. However, it is still unclear if HCV may cause a disease mimicking SjS or it is directly responsible for the development of SjS in a specific subset of patients. oral squamous cell carcinoma is the most common oral malignant tumour and at least in some part of the world could be linked to HCV.

关键词： Hepatitis C virus lichen planus oral lichen planus Sjogren’ s syndrome Sialadenitis oral squamous cell carcinoma

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