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oral glucose tolerance test in diabetes,the old method revisited

World Journal of Diabetes 2021年第6期12卷 786-793页

作者： Feng Yu Kuo Kai-Chun Cheng Yingxiao Li Juei-Tang Cheng Cardiovascular Center Veterans General HospitalKaohsiung 82445Taiwan Department of Pharmacy College of Pharmacy and Health CareTajen UniversityPingtung 90741Taiwan Pharmacological Department of Herbal Medicine and Department of Psychosomatic Internal Medicine Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshima 890-8544Japan Department of Nursing Tzu Chi University of Science and TechnologyHualien 973302Taiwan Department of Medical Research Chi-Mei Medical CenterTainan 71004Taiwan

The oral glucose tolerance test(OGTT)has been widely used both in clinics and in basic research for a long *** is applied to diagnose impaired glucose tolerance and/or type 2 diabetes mellitus in ***,it has been employed in research to investigate glucose utilization and insulin sensitivity in *** main aim of each was quite different,and the details are also somewhat ***,the time or duration of the OGTT was the same,using the 2-h post-glucose load glycemia in both,following the suggestions of the American Diabetes ***,the use of 30-min or 1-h post-glucose load glycemia in clinical practice has been recommended by several *** this review article,we describe this new view and suggest perspectives for the ***,quantification of the glucose curve in basic research is also *** in clinical practice,the incremental area under the curve is not suitable for use in the studies involving animals receiving repeated treatments or chronic *** discuss the potential mechanisms in ***,variations between bench and bedside in the application of the OGTT are ***,the newly identified method for the OGTT must achieve a recommendation from the American Diabetes Association or another official unit *** conclusion,we summarize the recent reports regarding the OGTT and add some of our own perspectives,including machine learning and others.

关键词： oral glucose tolerance test Impaired glucose tolerance glucose Utilization Type 2 diabetes Area under the curve

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Changes of ghrelin following oral glucose tolerance test in obese children with insulin resistance

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World Journal of Gastroenterology 2008年第12期14卷 1919-1924页

作者： Xiu-Min Wang You-Jun Jiang Li Liang Li-Zhong Du Department of endocrinology The Children's Hospital of ZhejiangUniversity School of Medicine 57 Zhugan Xiang Hangzhou310003 Zhejiang Province China

AIM： To characterize changes in ghrelin levels in response to oral glucose tolerance test （OGTT） and to correlate changes in ghrelin levels with changes in insulin and glucose following OGTT in Chinese obese children of Tanner Ⅰ and Ⅱ stage with insulin resistance. METHODS： 22 obese children with insulin resistance state were divided into four groups according to their Tanner stage and gender： boys of Tanner Ⅰ （fir- Ⅰ ）, boys of Tanner Ⅱ（BT-Ⅱ ）, girls of Tanner Ⅰ （GT- Ⅰ ）, girls of Tanner Ⅱ （GT-Ⅱ）. Ghrelin, insulin and glucose were measured at 0, 30, 60 and 120 rain following OGTT. The control children with normal BMI were divided into control boys of Tanner Ⅰ （CBT- Ⅰ, n = 6）, control boys of Tanner Ⅱ （CBT-Ⅱ, n = 5）, control girls of Tanner Ⅰ （CGT- Ⅰ, n = 6）, control girls of Tanner Ⅱ （CGT-Ⅱ, n = 5）. Fasting serum ghrelin levels were analyzed. RESULTS： Ghrelin levels were lower in obese groups. Ghrelin levels of control group decreased in Tanner Ⅱ stage （CGT- Ⅰ vs CGT-Ⅱ t = -4.703, P = 0.001; CBT- Ⅰ vs CBT- Ⅱ t = -4.794, P = 0.001）. Basal ghrelin levels in fir-Ⅱ decreased more significantly than that in BT- Ⅰ group （t = 2.547, P = 0.029）. Ghrelin levels expressed a downward trend after OGTT among obese children. The decrease in ghrelin levels at 60 min with respect to basal values was 56.9% in BT- Ⅰ. Ghrelin concentrations at 0 min correlated directly with glucose level at 0 min in fir- Ⅰ （r = 0.898, P = 0.015）. There wasn＇t a significant correlation of ghrelin changes with glucose changes and insulin changes during OGTT in obese children with insulin resistance. CONCLUSION： In conclusion, in obese children with insulin resistance, ghrelin levels decreased with advancing pubertal stage. Ghrelin secretion suppression following OGTT was influenced by gender and pubertal stage. Baseline ghrelin levels and ghrelin suppression after OGTT did not significantly correlate with the degree of insulin resistance and insulin sensitivity.

关键词： Ghrelin oral glucose tolerance test Insulinresistance Obese children

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The role of oral glucose tolerance test in screening for diabetes mellitus in the elderly of Harbin, China

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Chinese Medical Journal 2005年第5期118卷 418-420页

作者： ZHANGYan-qiao ZHANGYi-na CUICan FANYing CHANGMan-li YUWei-gang LIUFeng-chen TANNing ZHANGJin-chao DepartmentofGeriatricsSecondAffiliatedHospitalofHarbinMedicalUniversity Harbin150086China ClinicalLaboratoryCenterSecondAffiliatedHospitalofHarbinMedicalUniversity Harbin150086China DepartmentofEndocrinologySecondAffiliatedHospitalofHarbinMedicalUniversity Harbin150086China

Though diabetes is common worldwide, the proportion of cases diagnosed is not high. Nearly fifty percent of patients with diabetes mellitus (DM) in US are undiagnosed.~1 The ratio might be higher in China. It has been suggested that diabetes may be present 4 to 7 years before diagnosis.~2 (Many of) the complications appear to be present at the time of diagnosis of the diabetic status.~1 (Screening for) diabetes in early stage of diabetes is thus a worthwhile exercise.

关键词： oral glucose tolerance test diabetes mellitus diagnosis optimal fasting plasma glucose cut-point

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Utility of oral glucose tolerance test in predicting type 2 diabetes following gestational diabetes:Towards personalized care

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World Journal of Diabetes 2021年第10期12卷 1778-1788页

作者： Riad Abdel Latif Bayoumi Amar Hassan Khamis Muna A Tahlak Taghrid F Elgergawi Deemah K Harb Komal S Hazari Widad A Abdelkareem Aya O Issa Rakeeb Choudhury Mohamed Hassanein Jeyaseelan Lakshmanan Fatheya Alawadi Department of Basic Medical Sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates Department of Biostatistics HBMDCMohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates Department of Obstetrics and Gynecology Dubai Health AuthorityDubai 123United Arab Emirates Department of Endocrinology Dubai Health AuthorityDubai 123United Arab Emirates Department of Biostatistics Mohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates

BACKGROUND Women with gestational diabetes mellitus(GDM)are at a seven-fold higher risk of developing type 2 diabetes(T2D)within 7-10 years after childbirth,compared with those with normoglycemic *** raised fasting blood glucose(FBG)levels has been said to be the main significant predictor of postpartum progression to T2D,it is difficult to predict who among the women with GDM would develop ***,we conducted a cross-sectional retrospective study to examine the glycemic indices that can predict postnatal T2D in Emirati Arab women with a history of *** To assess how oral glucose tolerance test(OGTT)can identify the distinct GDM pathophysiology and predict possible distinct postnatal T2D *** The glycemic status of a cohort of 4603 pregnant Emirati Arab women,who delivered in 2007 at both Latifa Women and Children Hospital and at Dubai Hospital,United Arab Emirates,was assessed retrospectively,using the International Association of Diabetes and Pregnancy Study Groups(IADPSG)*** the total,1231 women were followed up and assessed in *** FBG and/or the 2-h blood glucose(2hrBG)levels after a 75-g glucose load were measured to assess the prevalence of GDM and T2D,according to the IADPSG and American Diabetes Association(ADA)criteria,*** receiver operating characteristic curve for the OGTT was plotted and sensitivity,specificity,and predictive values of FBG and 2hrBG for T2D were *** Considering both FBG and 2hrBG levels,according to the IADPSG criteria,the prevalence of GDM in pregnant Emirati women in 2007 was 1057/4603(23%),while the prevalence of pre-pregnancy T2D among them,based on ADA criteria,was 230/4603(5%).In the subset of women(n=1231)followed up in 2016,the prevalence of GDM in 2007 was 362/1231(29.6%),while the prevalence of prepregnancy T2D was 36/1231(2.9%).Of the 362 pregnant women with GDM in 2007,96/362(26.5%)developed T2D;142/362(39.2%)developed impaired fasting glucose;29/36

关键词： Type 2 diabetes Type 2 diabetes subtypes oral glucose tolerance test Diabetes Gestational diabetes mellitus subtypes

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Repetitiveness of the oral glucose tolerance test in children and adolescents

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World Journal of Clinical Pediatrics 2021年第3期10卷 29-39页

作者： Eirini Kostopoulou Spyridon Skiadopoulos Ioanna Partsalaki Andrea Paola Rojas Gil Bessie E Spiliotis Division of Paediatric Endocrinology and Diabetes Department of PaediatricsUniversity of Patras School of MedicinePatras 26504Greece Department of Medical Physics School of MedicineUniversity of PatrasPatras 26504Greece Department of Nursing University of PeloponneseTripolis 22100Greece

BACKGROUND Data regarding the most suitable diagnostic method for the diagnosis of glucose impairment in asymptomatic children and adolescents are ***,limited data are available on the reproducibility of the oral glucose tolerance test(OGTT)in children and adolescents who are obese(OB).AIM To investigate the usefulness of the OGTT as a screening method for glucose dysregulation in children and *** Eighty-one children and adolescents,41 females,either overweight(OW),OB or normal weight(NW)but with a strong positive family history of type 2 diabetes mellitus(T2DM),were enrolled in the present observational study from the Outpatient Clinic of Paediatric Endocrinology of the University Hospital of Patras in *** or two 3-h OGTTs were performed and glucose,insulin and Cpeptide concentrations were measured at several time points(t=0 min,t=15 min,t=30 min,t=60 min,t=90 min,t=120 min,t=180 min).RESULTS Good repetitiveness was observed in the OGTT response with regard to T2DM,while low repetitiveness was noted in the OGTT response with regard to impaired glucose tolerance(IGT)and no repetitiveness with regard to impaired fasting glucose(IFG).In addition,no concordance was observed between IFG and *** the 1st and 2nd OGTTs,no significant difference was found in the glucose concentrations between NW,OW and OB patients,whereas insulin and C-peptide concentrations were higher in OW and OB compared to NW patients at several time points during the ***,OW and OB patients showed a worsening insulin and C-peptide response during the 2nd OGTT as compared to the 1st *** In mild or moderate disorders of glucose metabolism,such as IFG and IGT,a diagnosis may not be reached using only one OGTT,and a second test or additional investigations may be *** glucose metabolism is profoundly impaired,as in T2DM,one OGTT is probably more reliable and adequate for establishing the *** weight and/or a positiv

关键词： oral glucose tolerance test Obesity Impaired fasting glucose Impaired glucose tolerance Children Adolescents

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The Use of Glycated Albumin in the Diagnosis of Gestational Diabetes Mellitus

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Journal of Biosciences and Medicines 2024年第1期12卷 19-28页

作者： Atochi Prince Woruka Celestine Osita John Obstetrics and Gynecology Department University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Obstetrics and Gynecology Department University of Port Harcourt Port Harcourt Nigeria

Gestational diabetes mellitus is the most common endocrine disorder in pregnancy and a cause of maternal and fetal morbidities and mortalities. The oral glucose tolerance test is the gold standard for diagnosing gestational diabetes mellitus. Nevertheless, the oral glucose tolerance test is time-consuming and requires patient preparation. On the contrary, Glycated albumin does not require patient preparation or administration of any substance. Most studies on glycated albumin in pregnancy were among the non-African population, and black Americans have higher glycated albumin levels than Caucasians. This study determined the use of glycated albumin in diagnosing gestational diabetes mellitus among pregnant women. The study was a prospective study of 160 pregnant women between 24 and 28 weeks of gestation at the University of Port Harcourt Teaching Hospital. The diagnosis of gestational diabetes mellitus was based on the World Health Organization 2013 criteria. The diagnostic value of glycated albumin was determined using the area under the receiver operator characteristic curve. The prevalence of gestational diabetes mellitus was 9.4% and the mean glycated albumin was 16.91% (±2.77). The area under the receiver operator characteristic curve for glycated albumin was 0.845 (95% CI 0.733 - 0.956;p = 0.0001). The optimal cut-off value of glycated albumin in the diagnosis of gestational diabetes mellitus was 18.9%. Glycated albumin was useful in the diagnosis of gestational diabetes mellitus at 24 to 28 weeks of gestation.

关键词： Glycated Albumin Gestational Diabetes Mellitus oral glucose tolerance test University of Port Harcourt Teaching Hospital

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Insulin Expression in Rats Exposed to Cadmium

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Biomedical and Environmental Sciences 2007年第4期20卷 295-301页

作者： LI-JIAN LEI TAI-YI JIN YUAN-FEN ZHOU Department of Occupational Health School of Public Health Fudan University Shanghai 200032 China

To investigate the effects of cadmium exposure on insulin expression in rats. Methods Eighteen adult SD rats were administered cadmium subcutaneously （0.5, 1.0, and 2.0 mg/kg bw）. The effects on endocrine of pancreas were assessed. The levels of cadmium and zinc in pancreas, blood and urine glucose, serum insulin and urine NAG （N-acyetyl-β-glucosaminidase） were determined. The gene expressions of metallothionein （MT） and insulin were also measured, and the oral glucose tolerance tests （OGTT） were carried out. Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group, which was associated with slight increase of zinc in pancreas. Cadmium-exposed rats （1.0 and 2.0 mg/kg bw） demonstrated a marked glucose intolerance. But the levels of serum insulin did not change significantly after cadmium administration, and the UNAG had no change in Cd-treated group. The gene expression of insulin decreased in 1.0 and 2.0 mg/kg bw cadmium-exposed groups, compared with the control group. The expression of MT-I was higher in the groups exposed to 1.0 and 2.0 mg/kg bw cadmium while the expression of MT-II was higher in the group exposed to 2.0 mg/kg bw cadmium. Conclusions Cadmium may be accumulated in the pancreas, resulting in the change of the expression of insulin, MT-I and MT-Ⅱ genes. Cadmium can influence the biosynthesis of insulin, but does not induce the release of insulin. The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium.

关键词： Cadmium Endocrine Insulin Metallothionein oral glucose tolerance test

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Study on the correlation and predictive value of serum pregnancyassociated plasma protein A, triglyceride and serum 25-hydroxyvitamin D levels with gestational diabetes mellitus

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World Journal of Clinical Cases 2020年第5期8卷 864-873页

作者： Zhuo Ren Dong Zhe Zhi Li Xin-Ping Sun Kai Yang Li Lin Department of Obstetrics and Gynecology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory Peking University International HospitalBeijing 102206China

BACKGROUND Gestational diabetes mellitus(GDM)is a concern due to its rapid increase in incidence in recent *** To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PAPP-A),triglyceride(TG),and 25-hydroxyvitamin D[25-(OH)D]with GDM in early *** A total of 99 patients in early pregnancy admitted to Peking University International Hospital from November 2015 to September 2017 were included,and underwent a fasting glucose test and oral glucose tolerance test screening at 24-28 wk of *** these cases with GDM,51 were assigned to group A and the remaining 48 cases without GDM were enrolled in group *** PAPP-A,TG and 25-(OH)D in the two groups were compared and their correlation with blood sugar was *** addition,their diagnostic value in GDM was determined using receiver operating characteristic(ROC)curve *** Group A had markedly lower serum PAPP-A and 25-(OH)D levels and a significantly higher serum TG level than group B,with statistical significance(Pglucose(FBG)levels(r=-0.605,P<0.001),(r=-0.597,P<0.001),while TG and FBG levels were positively correlated(r=0.628,P<0.001).The sensitivity,specificity,area under the curve(AUC)and optimal cut-off value of serum PAPP-A level in the diagnosis of GDM were 72.55%,82.35%,0.861 and 16.340,respectively,while the sensitivity of TG in diagnosing GDM was 86.27%,the specificity was 66.67%,the AUC was 0.813,with an optimal cut-off value of *** corresponding sensitivity,specificity,AUC and optimal cut-off value of serum 25-(OH)D were 64.71%,70.59%,0.721 and 23.140,***,multivariate logistic regression analysis revealed that FBG,vascular endothelial growth factor,Flt-1,serum PAPP-A,TG,and 25-(OH)D were related risk factors leading to GDM in *** Serum PAPP-A,TG,and 25-(OH)D levels

关键词： Early pregnancy Serum pregnancy-associated plasma protein A level Triglyceride Serum 25-hydroxyvitamin D Gestational diabetes mellitus oral glucose tolerance test

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Prevalence and characteristics of MAFLD in Chinese adults aged 40 years or older:A community-based study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 154-161页

作者： Jing Zeng Li Qin Qian Jin Rui-Xu Yang Guang Ning Qing Su Zhen Yang Jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Endocrinology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrinology and MetabolismShanghai Clinical Center for Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

Background: Nonalcoholic fatty liver disease(NAFLD) was recently proposed to be renamed metabolic dysfunction-associated fatty liver disease(MAFLD) with the diagnostic criteria revised. We investigated the similarities and differences in the prevalence and clinical characteristics of MAFLD and NAFLD in Chinese adults. Methods: A cross-sectional study of 9980 Chinese individuals aged 40 years or older was performed between 2011 and 2012 using randomized, stratifed cluster sampling in Shanghai, China. A detailed questionnaire and the results of abdominal ultrasonography, a standardized 2-h 75-g oral glucose tolerance test and blood biochemical examinations were collected. Results: A total of 9927 subjects were included in this study. The prevalence of MAFLD(40.3%) was significantly higher than that of NAFLD(36.9%)( P glucose(35.7%) and impaired glucose tolerance(40.9%). High risk of advanced fbrosis based on fbrosis-4 was highly prevalent(14.7%) in lean MAFLD with T2DM. Among 9927 subjects, 3481(35.1%) fulflled the diagnostic criteria for MAFLD and NAFLD(MAFLD + NAFLD +), 521(5.2%) MAFLD + NAFLD-, and 181(1.8%) MAFLD-NAFLD +. The MAFLD + NAFLD-group had more signifcant metabolic disorders than those in the MAFLD + NAFLD + group(all P < 0.05). Among MAFLD-NAFLD + subjects, 82.9% had metabolic disorders. Conclusions: The new defnition of MAFLD may better reflect the pathogenesis related to metabolism. Future research should focus on studying the natural history, pathogenesis and treatment effectivity of the overlap and non-overlap of NAFLD and MAFLD subjects.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Prevalence oral glucose tolerance test

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Design,synthesis and primary activity of thiomorpholine derivatives as DPP-Ⅳinhibitors

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Chinese Chemical Letters 2012年第3期23卷 297-300页

作者： Bei Han Jing Long Liu Yi Huan Peng Li Qi Wu Zi Yun Lin Zhu Fang Shen Da Li Yin Hai Hong Huang Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation Institute of Materia MedicaPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100050China

Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV（DPP-IV） inhibitors, with natural and non-natural L-amino acids as the starting *** structures were characterized by ~1H NMR,^（13）C NMR and *** target compounds were screened for the DPP-IV inhibition,and the preliminary SAR result was ***, compounds 4c,4d and 4f with good DPP-IV inhibition in vitro were further evaluated through a mouse oral glucose tolerance test （OGTT）.The preliminary result showed the potential value for further studies on those thiomorpholine-bearing compounds as DPP-IV inhibitors.

关键词： Thiomorpholine Dipeptidyl peptidaseⅣinhibitor Synthesis Structure-activity relationship oral glucose tolerance test

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