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Improved optrode array design and neural interface for optogenetics

Improved optrode array design and neural interface for optog...

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中国神经科学学会第十届全国学术会议

作者： Yi LU Cheng ZHONG Jian-Qing PAN Peng-Fei WEI Li-Ping WANG Shenzhen Key Lab of Neuropsychiatric Modulation Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Objective Optogenetics is a technology that combines optical control and genetic targeting using cell-type specific and optically-sensitive proteins for the precise manipulation of neuronal *** technology has been successfully used to understand the mechanisms of neuropsychiatric diseases through the precise spatial and temporal control of specific groups of neurons in a neural ***,it remains a great challenge to integrate optogenetic modulation with electrophysiological and behavioral read out methods as a means to explore the causal,temporally precise,and behaviorally relevant interactions of neurons in the specific circuits of freely behaving ***,the aim of this study is to develop a novel optrode array for long term applications in awaken *** We have designed and fabricated a high spatial resolution,multi-channel,and drivable optrode array for optical stimulating and recording in different brain regions of a rodent model at one ***,we have also developed optimal modification methods to build a low impedance and tissue friendly optrode/neural interface based on electro-active and bio-active materials,such as conducting polymers,hydrogels,neurotrophins and *** According to the requirements in the application of implantable optrode arrays,evaluation processes and characterization of the optrode arrays,both in vitro and in vitro,were exploited and *** investigation includes the electrochemical properties and biocompatibility of the optrode/tissue interface,and the long-term stability of the electrophisiological recording signals in freely-behaving ***,some other devices based on the technique of optogenetics and electrophysiology were developed,which were used to investigate the complex neural circuit processing mechanisms at the functional *** This work will provide theoretic and technical support for the development of a new generation of optrode arrays,a

关键词： optogenetics optorde neural circuits neural modulation brain activity mapping

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