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Dynamic analysis of beta oscillations in Parkinsonian neural networks with the pedunculopontine nucleus under optogenetic control

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Acta Mechanica Sinica 2024年第6期40卷 125-140页

作者： Yuzhi Zhao Honghui Zhang Ying Yu Lin Du Zichen Deng School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an710072China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introducing the PPN and related synaptic connections to the classic basal ganglia-thalamo-cortical ***,the improved model can not only simulate the basic saturated and beta activities mentioned in previous studies but also produce the normal alpha rhythm that is much closer to physiological ***,the results show that Parkinsonian oscillation activities can be controlled and modulated by the connection strength between the PPN and the globus pallidus internal nucleus(GPi)and the subthalamic nucleus(STN),supporting the fact that PPN is overinhibited in ***,the internal mechanism underlying these state transitions is further explained from the perspective of ***,both deep brain stimulation(DBS)and optogenetic technology are considered effective in terms of abnormal *** when a low-frequency DBS is added to the PPN,beta oscillations can be suppressed,but it is excited again as the DBS’s frequency gradually increases to a larger *** results coincide with the experimental results that low-frequency stimulation of the PPN is effective,and verify the rationality of the ***,we show that optogenetic stimulation of the globus pallidus external(GPe)expressing excitatory channelrhodopsin(ChR2)can effectively inhibit beta oscillations,whereas exciting the STN and PPN has a limited *** results are consistent with experimental reports suggesting that the symptoms of PD’s movement disorder can be alleviated under the GPe-ChR2,but not STN-ChR2,*** the functional role of the PPN and the feasibility of optogenetic stimulation remain to be clinically explored,the results obtained help us understand the mechanisms of beta oscillations in PD.

关键词： Pedunculopontine nucleus Beta oscillations optogenetic Deep brain stimulation Parkinson’s disease

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Temperature‑Gated Light‑Guiding Hydrogel Fiber for Thermoregulation During optogenetic Neuromodulation

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Advanced Fiber Materials 2023年第3期5卷 968-978页

作者： Guoyin Chen Siming Xu Qiangqiang Zhou Yuejiao Zhang Yuhan Song Jing Mi Yuehua Liu Kai Hou Jie Pan Department of Orthodontics Shanghai Stomatological Hospital and School of StomatologyFudan UniversityShanghai 200001China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620China

With the rise of optogenetic manipulation of neurons,the effects of optogenetic heating on temperature-sensitive physi-ological processes,and the damage to surrounding tissues have been *** manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber(TSOHF)using the integrated dynamic wet-spinning *** exhibits a structural tunable diameter,clear core/sheath structure,tunable temperature-sensitivity,excellent light propagation property(0.35 dB cm^(-1),650 nm laser light),and good biocompatibility(including tissue-like Young’s modulus,stable dimensional stability,and low cytotoxicity).Based on these properties,a potential application of optogenetic regulation of neural tissue(hypoglossal nerve),with controllable temperature using TSOHF was designed and ***,this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine.

关键词： Temperature-sensitive Light-guiding Fiber Thermoregulation optogenetic

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All-fiber-transmission photometry for simultaneous optogenetic stimulation and multi-color neuronal activity recording

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Opto-Electronic Advances 2022年第12期5卷 20-34,F0004页

作者： Zhongyang Qi Qingchun Guo Shu Wang Mingyue Jia Xinwei Gao Minmin Luo Ling Fu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China National Institute of Biological Sciences Beijing 102206China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beijing 100191China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Chinese Institute for Brain Research Beijing 102206China School of Life Sciences Tsinghua UniversityBeijing 100084China

Manipulating and real-time monitoring of neuronal activities with cell-type specificity and precise spatiotemporal resolution during animal behavior are fundamental technologies for exploring the functional connectivity, information transmission, and physiological functions of neural circuits in vivo. However, current techniques for optogenetic stimulation and neuronal activity recording mostly operate independently. Here, we report an all-fiber-transmission photometry system for simultaneous optogenetic manipulation and multi-color recording of neuronal activities and the neurotransmitter release in a freely moving animal. We have designed and manufactured a wavelength-independent multi-branch fiber bundle to enable simultaneous optogenetic manipulation and multi-color recording at different wavelengths. Further, we combine a laser of narrow linewidth with the lock-in amplification method to suppress the optogenetic stimulation-induced artifacts and channel crosstalk. We show that the collection efficiency of our system outperforms a traditional epi-fluorescence system. Further, we demonstrate successful recording of dynamic dopamine(DA) responses to unexpected rewards in the nucleus accumbens(NAc) in a freely moving mouse. We also show simultaneous dual-color recording of neuronal Ca2+ signals and DA dynamics in the NAc upon delivering an unexpected reward and the simultaneous optogenetic activating at dopaminergic terminals in the same location. Thus, our multi-function fiber photometry system provides a compatible, efficient, and flexible solution for neuroscientists to study neural circuits and neurological diseases.

关键词： fiber photometry all-fiber-transmission multi-color optogenetic neuroscience

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optogenetic activation of anterior cingulate cortex inhibits the heroin seeking behavior in rats

Optogenetic activation of anterior cingulate cortex inhibits...

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浙江省神经科学学会2015年会暨第七届宁波大学神经科学高级论坛

作者：赖苗军 Huaqiang Zhu Weisheng Chen Huifeng Liu Fuqiang Zhang Wenhua Zhou Laboratory of Behavioral Neuroscience Ningbo Addiction Research and Treatment CenterSchool of MedicineNingbo University

The aims of present study were to investigate effects of optogenetic activation of anterior cingulate cortex(ACC) on heroin self-administration,heroin seeking behavior induced by cues or heroin priming and learning and memory in *** rats in ACC optogenetic activation group were microinjected with 1μl pAAV-CaMK Ⅱ-hChR-EYFP into ACC(AP:+2.7mm,ML:0.5mm,DV:2.5mm),then implanted optical fiber 0.5mm above site of *** rats in sham operation group were microinjected with AVV-EYFP into *** rats were placed in operant chambers for a daily 4h heroin self-administration session under FR1 for consecutive 14 *** memory was taken eight-arms maze *** activation of ACC by illuminated by light(470 nm,5mW)decreased the enhancement of reference memory errors,working memory errors induced by heroin ***,optogenetic activation of ACC inhibited the heroin seeking behavior induced cues,which could be reversed partially by pretreatment with ***,optogenetic activation of NAc core(AP:+1.2mm,ML:±3.2mm,DV:-6.7mm)also inhibited the heroin seeking induced by *** conclusion,these data demonstrate that activation of ACC can improve the cognitive dysfunction induced by heroin chronic exposure,and projective pathway from ACC to NAc core may be involved in the heroin seeking behavior induced by cues

关键词： optogenetic Cognitive fuction Anterior cingulate cortex Nucleus accumbens Heroin Metabotropic glutamate receptor

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Rapid Antidepressant-Like Potential of Chaihu Shugan San Depends on Suppressing Glutamate Neurotransmission and Activating Synaptic Proteins in Hippocampus of Female Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 692-700页

作者： LU Chao GAO Zi-wei XING Shan WANG Hui-hui HUANG Yun-ke ZHOU Hang WU Lei Department of Chinese Medicine Preparations Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjing210029China College of Chinese Medicine Nanjing University of Chinese MedicineNanjing210046China Department of Chinese Medicine Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

Objective To explore the rapid antidepressant potential and the underlying mechanism of Chaihu Shugan San(CSS)in female *** Liquid chromatography mass spectrometry(LC-MS)/MS was used to determine the content of main components in CSS to determine its *** C57BL/6J mice were randomly divided into 4 groups,including control(saline),vehicle(saline),CSS(4 g/kg)and ketamine(30 mg/kg)*** were subjected to irregular stress stimulation for 4 weeks to establish the chronic mild stress(CMS)model,then received a single administration of *** hours later,the behavioral tests were performed,including open field test,tail suspension test(TST),forced swimming test(FST),novelty suppression feeding test(NSF),and sucrose preference test(SPT).Western blot analysis was used to detect the expression levels of N-methyl-D-aspartate receptor(NMDA)subtypes[N-methyl-D-aspartate receptor 1(NR1),NR2A,NR2B],synaptic proteins[synapsin1 and post synaptic density protein 95(PSD95)],and brain-derived neurotrophic factor(BDNF).Moreover,the rapid antidepressant effect of CSS was tested by pharmacological technologies and optogenetic interventions that activated glutamate receptors,*** Compared with the vehicle group,a single administration of CSS(4 g/kg)reversed all behavioral defects in TST,FST,SPT and NSF caused by CMS(P<0.05 or P<0.01).CSS also significantly decreased the expressions of NMDA subtypes(NR1,NR2A,NR2B)at 2 h in hippocampus of mice(all P<0.01).In addition,similar to ketamine,CSS increased levels of synaptic proteins and BDNF(P<0.05 or P<0.01).Furthermore,the rapid antidepressant effects of CSS were blocked by transient activation of NMDA receptors in the hippocampus(all P<0.01).Conclusion Rapid antidepressant effects of CSS by improving behavioral deficits in female CMS mice depended on rapid suppression of NMDA receptors and activation of synaptic proteins.

关键词： Chaihu Shugan San female rapid antidepressant potential N-methyl-D-aspartate receptor synapticprotein optogenetic Chinesemedicine

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