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DYNAMIC optical coherence elastography:A REVIEW

Journal of Innovative optical Health Sciences 2010年第4期3卷 221-233页

作者： XING LIANG VASILICA CRECEA STEPHEN A.BOPPART Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Department of Physics Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Departments of Electrical and Computer Engineering Bioengineering and Internal MedicineBeckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Biophotonics Imaging Laboratory Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA

With the development of optical coherence tomography,the application optical coherence elastography(OCE)has gained more and more attention in biomechanics for its unique features including micron-scale resolution,real-time processing,and non-invasive *** this review,one group of OCE techniques,namely dynamic OCE,are introduced and discussed including external dynamic OCE mapping and imaging of ex vivo breast tumor,external dynamic OCE measurement of in vivo human skin,and internal dynamic OCE including acoustomotive OCE and magnetomotive *** techniques overcame some of the major drawbacks of traditional static OCE,and broadened the OCE application *** by scientific needs to engineer new quantitative methods that utilize the high micron-scale resolution achievable with optics,results of biomechanical properties were obtained from biological *** results suggest potential diagnostic and therapeutic clinical *** from these studies also help our understanding of the relationship between biomechanical variations and functional tissue changes in biological systems.

关键词： optical coherence tomography optical coherence elastography biomechanics tissue characterization scattering phase measurements

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Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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Journal of Innovative optical Health Sciences 2017年第6期10卷 51-63页

作者： Vladimir Y.Zaitsev Alexandr L.Matveyev Lev A.Matveev Ekaterina V.Gubarkova Alexandr A.Sovetsky Marina A.Sirotkina Grigory V.Gelikonov Elena V.Zagaynova Natalia D.Gladkova Alex Vitkin Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46 Nizhny Novgorod 603950 Russia Nizhny Novgorod State Medical Academy 10/1 Minina Square Nizhny Novgorod 603005 Russia University of Toronto and University Health Network 610 University Avenue Toronto ON M5G 2M9Canada

In this paper,we point out some practical obstacles arising in realization of compressional optical coherence elastography(OCE)that have not attracted sufficient attention ***-cally,we discuss(i)complications in quantification of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor,(i)distorting influence of tisue suface curvature/corrugation on the subsurface strain distri-bution mapping,(ii)ways of signal-to-noise mtio(SNR)enhancement in OCE strain mapping when periodic averaging is not realized,and(iv)potentially significant infuence of tissue elastic nonlinearity on quantification of its *** pnactical approaches to mitigate the effects of these complications are also described.

关键词： optical coherence elastography optical coherence tomography phase-resolved methods strain mapping stiffness characterization

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