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Dynamic photonic barcodes for molecular detection based on cavity-enhanced energy transfer

Advanced Photonics 2020年第6期2卷 69-77页

作者： Yunke Zhou Zhiyi Yuan Xuerui Gong Muhammad D.Birowosuto Cuong Dang Yu-Cheng Chen Nanyang Technological University School of Electrical and Electronic EngineeringSingapore CINTRA UMI CNRS/NTU/THALES Singapore Nanyang Technological University School of Chemical and Biomedical EngineeringSingapore

optical barcodes have demonstrated a great potential in multiplexed bioassays and cell tracking for their distinctive spectral *** vast majority of optical barcodes were designed to identify a specific target by fluorescence emission spectra,without being able to characterize dynamic changes in response to analytes through *** overcome these limitations,the concept of the bioresponsive dynamic photonic barcode was proposed by exploiting interfacial energy transfer between a microdroplet cavity and binding ***-gallery modes resulting from cavity-enhanced energy transfer were therefore converted into photonic barcodes to identify binding activities,in which more than trillions of distinctive barcodes could be generated by a single *** spectral barcoding was achieved by a significant improvement in terms of signal-to-noise ratio upon binding to target *** studies and experiments were conducted to elucidate the effect of different cavity sizes and analyte *** fluorescence lifetime was implemented to investigate the role of radiative and non-radiative energy ***,microdroplet photonic barcodes were employed in biodetection to exhibit great potential in fulfilling biomedical applications.

关键词： whispering-gallery modes optical barcodes fluorescence resonance energy transfer molecular sensing biointerface cavity-enhancement

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