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Fourteen Days Post-Ovariectomy Estrogens Decline Is Associated with Anxiogenic Effects on Wistar Rats

Journal of Pharmacy and Pharmacology 2017年第12期5卷 869-876页

作者： Zemo Gamo Franklin Djiogue Sefirin Ketcha Wanda Germain Jean Magloire Seke Etet Paul Faustin Yonkeu Tatchou Floriane Gaelle Djikem Tadah Rudig Nikanor Awounfack Charline Florence Njamen Dieudonne Department of Animal Biology and Physiology Faculty of Science University of Yaounde L Yaounde P.O. Box 812 Cameroon Department of Psychology Faculty of Arts Letters and Social Science University of Yaounde L Yaounde P.O. Box 7011 Cameroon Department of Basic Health Sciences College of Applied Medical Sciences Qassim University Al-Qaseem 51452 Saudi Arabia

On study of the effects of estrogen deficiency on anxiety disorder by using ovariectomised animals, one discrepancy was the difference in behavioral testing delay following ovariectomy and the paradigms used. Thus, the aim of this study was to evaluate the anxiogenic effects of fourteen-day estrogen decline subsequent to ovariectomy on Wistar rats using EPM （elevated plus-maze） and open field.tests. As results, fourteen days of estrogens decline has induced an increase of anxiety-related behaviour by a reduction of the percentage of the number of entries into the open arm （p 〈 0.01） and an increase of the percentage of the number of entries into the closed arm （/9 〈 0.01） during the elevated plus-maze test. This anxiety-like behaviour was confirmed on the open field.test by a reduction of time spent in the centre of the arena （p 〈 0.05） as well as a reduction of crossing （p 〈 0.05） and an increase of the weight of faecal boli （p 〈 0.05） and grooming （p 〈 0.01）. Meanwhile, the administration of diazepam or estradiol valerate （1 mg/kg BW each） has corrected the anxious-like behaviour in both tests paradigms. These results suggest that fourteen days of estrogens decline was associated with an anxiety-related behaviour. This experimental model can constitute an excellent tool for the study of anxiolytic substances in menopause-related anxiety.

关键词： Ovariectomy estrogen decline anxiety EPM open field.

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