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Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

Virologica Sinica 2015年第2期30卷 130-145页

作者： Denis Avey Brittany Brewers Fanxiu Zhu Department of Biological Science Florida State University Tallahassee 32306 USA

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.

关键词： Kaposi’s sarcoma-associated herpesvirus(KSHV) Kaposi’s sarcoma epigenetic epigenome herpesvirus oncovirus chromatin

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Viral integration detection strategies and a technical update on Virus-Clip

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BIOCELL 2021年第6期45卷 1495-1500页

作者： DANIEL WAI-HUNG HO XUEYING LYU IRENE OI-LIN NG Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

oncovirus infection is crucial in human *** oncoviruses can lead to structural variations in the human genome known as viral genomic integration,which can contribute to *** viral integration detection tools differ in their underlying algorithms pinpointing different aspects or features of viral integration *** discuss about major procedures in performing viral integration *** importantly,we provide a technical update on Virus-Clip to facilitate its usage on the latest human genome builds(hg19 and hg38)and the adoption of multi-thread mode for faster initial read *** comparing the execution of Virus-Clip using single-thread and multi-thread modes of read alignment on targeted-panel sequencing data of HBV-associated hepatocellular carcinoma patients,we demonstrate the marked improvement of multi-thread mode in terms of significantly reduced execution time,while there is negligible difference in memory *** together,with the current update of Virus-Clip,it will continue supporting the in silico detection of oncoviral integration for better understanding of various human malignancies.

关键词： oncovirus Viral genomic integration In silico detection Tumorigenesis Human malignancies

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Cytomegalovirus in human brain tumors:Role in pathogenesis and potential treatment options

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World Journal of Experimental Medicine 2015年第1期5卷 1-10页

作者： Cecilia Soderberg-Nauclér John Inge Johnsen Experimental Cardiovascular Research Unit Department of MedicineSolnaCenter for Molescular MedicineKarolinska InstitutetKarolinska University Hospital171 76 StockholmSweden Childhod Cancer Research Unit Department of Women’s and Children’s HealthKarolinska InstitutetS-171 76 StockholmSweden

During the last years increasing evidence implies that human cytomegalovirus(CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.

关键词： Cytomegalovirus oncovirus Glioblastoma Medulloblastoma Brain tumor

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