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Single low-dose lipopolysaccharide preconditioning:neuroprotective against axonal injury and modulates glial cells

Neuroimmunology and Neuroinflammation 2017年第1期4卷 6-15页

作者： Ryan C.Turner Zachary J.Naser Brandon P.Lucke-Wold Aric F.Logsdon Reyna L.Vangilder Rae R.matsumoto Jason D.Huber Charles L.Rosen Department of Neurosurgery West Virginia UniversitySchool of MedicineMorgantownWV26506USA Center for Neuroscience West Virginia UniversitySchool of MedicineMorgantownWV 26506USA Department of Basic Pharmaceutical Sciences West Virginia UniversitySchool of PharmacyMorgantownWV 26506USA Center for Health Restoration West Virginia UniversitySchool of NursingMorgantownWV 26506USA

Aim:Over 7 million traumatic brain injuries (TBI) are reported each year in the United ***,treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly *** (LPS) administration before controlled cortical impact can contribute to ***,the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains ***:The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight *** was administered 7 days prior to *** administration reduced locomotion,which recovered completely by time of ***:LPS preconditioning significantly reduced the post-injury gliosis response near the corpus callosum,possibly by downregulating the oncostatin m *** novel findings demonstrate a protective role of LPS preconditioning against diffuse axonal *** preconditioning successfully prevented neurodegeneration near the corpus callosum,as measured by fluorojade ***:Further work is required to elucidate whether LPS preconditioning confers long-term protection against behavioral deficits and to elucidate the biochemical mechanisms responsible for LPS-induced neuroprotective effects.

关键词： Lipopolysaccharide preconditioning oncostatin m receptor diffuse axonal injury gliosis neuroprotection

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