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Long-term outcome of olfactory ensheathing cell transplant in chronic spinal cord injured patients with a response to Dobkin’ s article“cellular Transplants in China:Observational Study from the Largest Human Experiment in Chronic Spinal Cord Injury”

Long-term outcome of olfactory ensheathing cell transplant i...

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中国医师协会神经外科医师分会第四届全国代表大会

作者：黄红云 Beijing Hongtianji Neuroscience Academy Department of Neurosurgery Beijing rehabilitation Center Neuroscience Institute of Taishan Medical University

＜正＞Objective The neurorestorative effect of olfactory ensheathing cell（OEC） therapy remains clinically *** purpose of this study was to determine the long - term follow - up outcome of fetal bulb OECs for the patients with chronic spinal cord injury（SCI） while responding to Dobkin’s article,"cellular Transplants in China:Observational Study from the Largest Human Experiment in Chronic Spinal Cord Injury". Methods Of 497 chronic SCI patients（388 Chinese and 109 foreigners ）,following fetal OEC transplant for a period of 3.52 1.07 years,136 patients were followed up *** were divided into two groups based on their rehabilitative training,which including Group A（n = 97） in sufficient rehabilitation and Group B（n = 39） in insufficient *** patients were assessed by using the American Spinal Injury Association（ASIA） standard and the Xishan Hospital Spinal Cord Injury Functional Rating Scale（SCI -FRS）.Some of them were evaluated by magnetic resonance imaging（MRI）,electromyography（EMG）, and,paravertebral sensory evoked potential（PVSEP）. Results No deterioration or complications were found in any of the patients within the follow - up duration.（1） According to ASIA assessment standard,mean motor scores increased from 41.15±21.29 to 46.30±20.80（P ＜0.01 ）,light touch scores from 55.45±26.66 to 67.56±25.71（P ＜0.01 ）,pain scores from 56.45±26.60 to 65.12±25.01（P＜ 0.01 ） from pre - operation to post - operation in Group ***,mean motor scores increased from 37.85±18.39 to 38.69±18.28（P ＜0.05）,light touch scores from 47.08±22.48 to 47.15±22.30（P ＞ 0.05 ）,pain scores from 47.41±23.08 to 47.82±24.07(（P ＞ 0.05） in Group *** Group A with Group B,the score change in terms of motor, light touch,and pain were remarkably different（all P ＜0.01 ）.（2） According to Xishan Hospital SCIFRS assessment standard,the total scores increased from 19.90±11.54 to 24.73±11.57（P ＜0.01 ） in Group A,while the scores from 17.92±9.30 to 19.72±9.20（P ＜

关键词： olfactory ensheathing cell Intraspinal transplantation Chronic spinal cord injury Longterm follow up Clinical study American spinal injury association standard Xishan hospital spinal cord injury functional rating scale Magnetic resonance imaging Electromyography Paravertebral sensory evoked potential Neurorestoratology.

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Transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury:A Web of Science-based literature analysis

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Neural Regeneration Research 2012年第35期7卷 2818-2825页

作者： Xing Zhang Fei Yin Li Guo Dongxu Zhao Gu Gong Lei Gao Qingsan Zhu Department of Spine Surgery the First Hospital of Jilin University Department of Toxicology School of Public Health Jilin University Department of Pathogenobiology Norman Bethune College of Medicine Jilin University Jilin University Mycology Research Center (JUMRC)

OBJECTIVE： To identify global research trends in transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury. DATA RETRIEVAL： We performed a bibliometric analysis of studies on transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury published from 2002 to 2011 and retrieved from the Web of Science, using the key words spinal cord injury along with either neural stem cell, Schwann cell or olfactory ensheathing cell. SELECTION CRITERIA： Inclusion criteria：（a） peer-reviewed published articles on neural stem cells, Schwann cells or olfactory ensheathing cells for spinal cord injury indexed in the Web of Science; （b） original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial materials and news items; and （c） published between 2002 and 2011. Exclusion criteria：（a） articles that required manual searching or telephone access; （b） documents that were not published in the public domain; and （c） corrected papers. MAIN OUTCOME MEASURES：（1）Annual publication output, distribution by journal, distribution by institution and top-cited articles on neural stem cells; （2） annual publication output, distribution by journal, distribution by institution and top-cited articles on Schwann cells; （3） annual publication output, distribution by journal, distribution by institution and top-cited articles on olfactory ensheathing cells. RESULTS： This analysis, based on articles indexed in the Web of Science, identified several research trends among studies published over the past 10 years in transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury. The number of publications increased over the 10-year period examined. Most papers appeared in journals with a focus on neurology, such as Journal of Neurotrauma, Experimental Neurology and Gila. Research institutes publishing on the use of neural stem cells to

关键词： spinal cord neuron nerve fiber neural stem cell Schwann cell olfactory ensheathing cell transplantation genetic engineering tissue engineering neural regeneration

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Culture and purification of human fetal olfactory ensheathing cells using different attachment rates combined with intermittent NT3 nutrition

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Journal of Nanjing Medical University 2007年第5期21卷 307-310页

作者： Qiang Li Xijing He Guozhou Rao Pei Fan Bin Wang Department of Orthopedics the Second Affiliated Hospital of Xi＇ an Jiaotong University Xi＇ an 710004 shanxi province China Hospital of Stomatology Xi＇ an Jiaotong University Xi＇ an 710004 shanxi province China

Objective：To explore a simple and pragmatic method to obtain sufficient olfactory ensheathing cells from human fetus by selective attachment of harvested cells combined with intermittent NT3 nutrition. Methods：DMEM/F12 culture solution including 10% fetal bovine serum or NT3 was used to culture olfactory ensheathing cells intermittently every 48 h. The cell state and growth rates of OECs were observed, and P75 staining was used to estimate the purity of the cells. Results：Human fetal OECs were positive with P75 immunocytochemical staining. OECs in dipolar or tripolar shape formed networks by their processes in vitro. The purity of OECs in ＂good state＂ was about 95% at 9 d and 83% on 12 d, respectively. Conclusion：The method of using different attachment rates combined with intermittent NT3 addition is a simple and effective way to culture and purify OECs.

关键词： olfactory ensheathing cell cell culture purification NT3

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