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Chronic progression of recurrent orthokeratinized odontogenic cyst into squamous cell carcinoma:A case report

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World Journal of Clinical Cases 2019年第13期7卷 1686-1695页

作者： Ruo-Yi Wu Zhe Shao Tian-Fu Wu The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan 430072 Hubei Province China Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Wuhan 430072 Hubei Province China

BACKGROUND Orthokeratinized odontogenic cyst (OOC) is a benign odontogenic cyst. It is a variant of the common odontogenic keratocyst (OKC). This case report describes a rare malignant transformation of OOC, with the aim of raising awareness of the malignant potential of OOC and distinguishing it from OKC. CASE SUMMARY In August 2018, a 52-year-old man was referred to the Department of Oral Maxillofacial and Head–Neck Oncology of Wuhan University. The patient presented with severe pain in the left mandible for 2 mo, and had a 5-year history of osteomyelitis and mandibular cyst with three recurrences. His latest diagnosis by pathological examination was OOC of the left mandible with mild-tomoderate local proliferation. However, the cyst showed malignant potential by radiographic examination. We performed partial mandibulectomy and sent the lesion tissue for pathological examination. As expected, the cyst had deteriorated to moderately differentiated squamous cell carcinoma. During postoperative follow-up, the patient went for chemotherapy in September 2018 and successfully completed four cycles. CONCLUSION Surgeons should be more aware of OOC, which is usually benign but can become malignant.

关键词： Orthokeratinized odontogenic cyst Cancerization Cancer recurrence Squamous cell carcinoma odontogenic keratocyst Case report

Ghost cell odontogenic carcinoma of the jaws: Report of two cases and a literature review

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World Journal of Clinical Cases 2019年第3期7卷 357-365页

作者： Meng-Qi Jia Jun Jia Li Wang Hai-Xiao Zou State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Department of Pathology School and Hospital of Stomatology Wuhan University Department of Stomatology the Second Affiliated Hospital of Nanchang University

BACKGROUND Ghost cell odontogenic carcinoma(GCOC) is a rare malignant odontogenic epithelial tumor with features of benign calcifying odontogenic cysts. Herein, we report two new cases of GCOC and systematically review the previous *** SUMMARY In case 1, a 46-year-old man complained of painless swelling of the right maxilla for 3 years, with a 1-mo history of hemorrhinia in the right nasal cavity. In case 2,a 72-year-old man was referred to our hospital with a chief complaint of painful swelling of the right mandible. Initially, the preliminary diagnoses were ameloblastomas. Thus, the two patients underwent resection of the tumor under general anesthesia. Finally, immunohistochemical examination confirmed the diagnosis of GCOC. The patient in case 1 was followed for 2 years, with no evidence of recurrence. However, the patient in case 2 was lost to *** GCOC is a rare malignant odontogenic epithelial tumor with high *** extensive resection is necessary for the definitive treatment of GCOC.

关键词： Ghost cell odontogenic carcinoma Pathological features Treatment Prognosis Case report

Extensive odontogenic Myxoma of the Maxilla: A Case Report and Review of Literature

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第6期3卷 364-370页

作者： Sally Nguyen Simon-Pierre Charbonneau Julien E. Ghannoum Eric Bissada Department of Otolaryngology and Head & Neck Surgery Centre Hospitalier de l’Université de Montréal Montreal Canada Department of Stomatology Centre Hospitalier de l’Université de Montréal Montreal Canada

odontogenic myxomas (OM), also called odontogenic fibromyxomas, are rare tumours of the jawbones. They are benign tumours that can be locally invasive and aggressive, but seldom undergo malignant transformation and do not give rise to metastases. They are often asymptomatic and present as painless swelling. We present herein the case of a 24-year-old patient, with an incidental finding of a maxillary lesion. The lesion expanded to the surrounding soft tissues of the face, the maxillary sinus, the nasal cavity and the ethmoidal cells. After confirmation of OM on biopsy, the patient underwent an extended right radical en bloc maxillectomy with immediate reconstruction of the inferior orbital rim. A literature review of clinical symptoms, radiological presentation, differential diagnosis and surgical management of OM is discussed.

关键词： odontogenic Myxoma odontogenic Fibromyxoma Maxilla

Histopathological Examination and Literature Review of Orthokeratinized odontogenic Cyst

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Open Journal of Stomatology 2019年第5期9卷 125-135页

作者： Hirotoshi Iwai Takehiro Suzuki Tomoko Suzuki Juri Muramori Hiroyuki Seto Mitsuko Nakayama Tadahiko Utsunomiya Masaaki Suemitsu Kayo Kuyama Satoshi Hirayama Department of Operative Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan

Background: With transitions in the disease concept of orthokeratinized odontogenic cyst (OOC), the pathogenesis and etiology have not been sufficiently elucidated. Objectives: OOC cases were reclassified and observed to understand the clinico-histopathological characteristics. In addition, literature review of OOC was performed to better organize the pathology. Materials and methods: Subjects with jawbone cysts lined by keratinized stratified squamous epithelium from 2005 to 2018 were reclassified, and clinico-histopathological findings were analyzed. Previous reports of OOC/orthokeratinized-type odontogenic keratocyst (OKC) from 1980 to 2019 were organized. Results: Five cases of OOC were diagnosed, representing 2.1% of odontogenic developmental cysts (total, 239 cases). Mean age was 37.6 years, with a female predominance. The mandibular molar area was the frequent site, and all cysts were solitary. Sixty percent involved an impacted tooth. Mean maximum diameter of the cyst was 2.2 cm. Histopathologically, 4 cases were unilocular, and partial palisading of the basal layer and scattered epithelial islands were observed in 2 cases each and formation of daughter cysts was noted in 3 cases. Previous papers described that most were unilocular and related to impacted teeth. Mean age ranged between 20 and 40 years, and the mandibular molar region was dominant. Recurrence rates were low. Conclusion: OOC shows a different biological attitude to OKC and is closer to dentigerous cyst. Meanwhile, OOC shows a similar histology of epidermoid cysts accompanying the granular layer. We thus surmised that OCC represents an independent concept as an odontogenic developmental cyst.

关键词： Orthokeratinized odontogenic Cyst (OOC) odontogenic Developmental Cyst Literature Review

A unique case of a calcifying cystic odontogenic tumor

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Open Journal of Stomatology 2013年第6期3卷 314-317页

作者： Shoko Gamoh Yukako Nakashima Hironori Akiyama Kimishige Shimizutani Takuro Sanuki Junichiro Kotani Koji Yamada Shosuke Morita Kazuya Tominaga Masahiro Wato Akio Tanaka Department of Anesthesiology Osaka Dental University Osaka Japan Department of Oral and Maxillofacial Surgery Osaka Dental University Osaka Japan Department of Oral Pathology Osaka Dental University Osaka Japan Department of Oral Radiology Osaka Dental University Osaka Japan

The calcifying odontogenic cyst was first reported by Gorlin et al. in 1962. At that time, it was classified as a cyst related to the odontogenic apparatus, although it was later renamed as a calcifying cystic odontogenic tumor by the WHO calcification in 2005 due to its histological complexity, morphological diversity and aggressive proliferation [2]. Here, we describe a case of a calcifying cystic odontogenic tumor in a 4- year-old boy. The lesion was surgically removed, and the histopathological examination revealed it to be a cystic tumor with ghost cells, a stellate reticulum and small amount of dentinoid tissue in the cystic wall.

关键词： Calcifying Cystic odontogenic Tumor Diagnostic Imaging Computed Tomography

Calretinin Expression in Unicystic Ameloblastoma and odontogenic Cysts

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Journal of Biosciences and Medicines 2020年第4期8卷 111-120页

作者： Efetobo Victor Orikpete Osawe Felix Omoregie Michael Akin Ojo University of Port Harcourt Port Harcourt Nigeria University of Benin Benin Nigeria

Background: Unicystic ameloblastoma arises from similar tissues as the odontogenic cysts. It may also arise from the epithelial lining of these cysts. Furthermore, the epithelial lining of unicystic ameloblastoma is variable and may be almost completely nondescript, which may lead to diagnostic confusion with odontogenic cysts. Calretinin is a calcium-binding protein that has been suggested to be a specific immunohistochemical marker for ameloblastic tissues. The aim of this study was to investigate the usefulness of calretinin in the differentiating unicystic ameloblastoma from odontogenic keratocyst, dentigerous cyst and radicular cyst of the jaws. Materials and Methods: Formalin-fixed, paraffin embedded tissue blocks of 23 unicystic ameloblastomas, 6 odontogenic keratocysts, 8 dentigerous cysts and 10 radicular cysts were utilized. Five micrometer thick sections were made from the tissue blocks and mounted on silanized glass slides. Immunohistochemical staining was done using a 1:100 dilution of mouse monoclonal anti-calretinin primary antibodies (Abcam, SA;Clone 1F5H1) and incubating overnight at 4°C. The staining reaction was visualised using diaminobenzidine substrate solution. Stained tissue sections were evaluated for the presence, distribution, and intensity of staining of the immunoreactive cells. Data analysis was done using SPSS version 23. Statistical tests employed were Chi square test and Kruskal-Wallis test. The level of significance was set at 95% (p-value Results: Calretinin expression was seen in 14 (60.9%) cases of unicystic ameloblastoma, 3 (50.0%) cases of odontogenic keratocyst and a lone (12.5%) case of dentigerous cyst. None of the 10 cases of radicular cyst showed positive expression of calretinin. Staining in unicystic ameloblastoma was mostly localized to the superficial layers, whereas in odontogenic keratocyst it involved all layers of the epithelial lining. There was significant association between lesion type and the immunohistoch

关键词： Calretinin odontogenic Cyst Ameloblastoma

Severity Score as a Prognostic Factor for Management of Infections of odontogenic Origin, a Study of 100 Cases

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Open Journal of Stomatology 2017年第1期7卷 25-34页

作者： Roman Mirochnik Shareef Araidy Victoria Yaffe Imad Abu El-Naaj Oral and Maxillofacial Surgery Department “Baruch Padhe” Medical Center Poria Israel Bar Ilan University Israel

Purpose: The main objective of the current study is to determine whether it is possible to correlate the longevity of the hospitalization period (LOS) to efficacy of surgical treatment regime and severity scoring. Materials and Methods: A total of 100 patients met our inclusion criteria. All patient records, including results of hematologic and biochemical parameters, were recorded. The patients were later subcategorized further according to a severity score (“Low, Moderate, Severe”) of their main facial space involvement. The main analysis of the study is a regression analysis model;all the variables (sex, age, CRP, white blood cell count, fever, space, and etiology) were stratified according to the overall hospital stay. A crosstab comparison was performed next;the variables were categorized and combined with hospital stay, and then entered in Spearman’s rank correlation coefficient or Spearman’s rho (ρ), 2-tailed (t) Test, and regression equation. The significance level was set at p Results: The most prevalent anatomical space infection was vestibular space abscess or cellulitis 33%, followed by an infraorbital space abscess or cellulitis 17%. Most commonly involved teeth are lower molars with 43% of the total, upper central sixth with 20% and upper molars with 10%;mandibular origin was found to be the cause in 54%. The regression equation showed no linear relation between CRP with the overall hospital stay (p > 0.05). No systemic temperature values were found to be correlated to any space involved or LOS. Log-rank chi-square effect tests indicated only a significant effect of severity, p =0.00016. The “Moderate & Severe” group compared to the “Low” group had a longer median LOS, 4.5 (2 to 8) vs 3 (1 to 8) respectively. Conclusion: The findings of this study have shown severity scoring to be statistically significant parameter in LOS prediction.

关键词： CRP odontogenic Infection Dental Abscess C-Reactive Protein

A Large Calcifying Cystic odontogenic Tumor Occupying the Maxillary Sinus: A Case Report and Review of Literature

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Open Journal of Stomatology 2017年第5期7卷 291-298页

作者： Hiroshi Nakamura Shigehiro Tamaki Nobuhiro Ueda Nobuhiro Yamakawa Yuichiro Imai Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Nara Japan Department of Oral Surgery Takai Hospital Tenri Japan Department of Oral Surgery Rakuwakai Otowa Hospital Kyoto Japan

Calcifying cystic odontogenic tumor (CCOT) is an uncommon benign cystic neoplasm of the jaw that develops from the odontogenic epithelium. It is clinically characterized as a painless—slow-growing tumor that affects the maxilla as well as the mandible, and generally occurs in young adults in the third or fourth decade of life. Herein, we present the case of a 16-year-old Japanese boy who showed a CCOT in the maxillary sinus. Panoramic radiography showed a unilocular lesion in the left maxillary sinus. Computed tomography showed an approximately 5-cm well-defined unilocular expansile lesion with multiple radiopaque calcific specks, arising from the left maxillary alveolar ridge. The lesion was surgically removed, under general anesthesia, and the patient was followed up for 3 years after the surgery, and there have not been any signs of recurrence.

关键词： Calcifying Cystic odontogenic Tumor Maxillary Sinus Ghost Cells

Calcifying cystic odontogenic tumour manifesting in the maxillary antrum: Case report

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Open Journal of Stomatology 2013年第9期3卷 504-506页

作者： Eunice Kihara Richard Owino Josiah Otwoma Elizabeth Dimba Mark Chindia Department of Oral & Maxillofacial Surgery—Oral Pathology & Oral Medicine University of Nairobi Nairobi Kenya Department of Paediatric Dentistry & Orthodontics University of Nairobi Nairobi Kenya

A case is presented of a 15-year-old boy who manifested the calcifying cystic odontogenic tumour (CCOT) in the left maxillary antrum of an unknown duration. In addition, the patient had a high arched palate and multiple impacted teeth of the normal series and supernumerary type including mesiodens as demonstrated in an orthopantomograph.

关键词： Case Reports odontogenic Cyst Calcifying odontogenic Tumours Maxillary Sinus