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ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation

International Journal of Ophthalmology(English edition) 2023年第7期16卷 1138-1144页

作者： Shu-Xian Fan Wen-Hui Wang Peng Zeng Ke-Zhi Huang Yu-Xin Hu Jing Wang Yi-Qing Li Jian-Hui Xiao Department of Ophthalmology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina Department of Hematology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina

AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT).METHODS:Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020.They completed two questionnaires:the ocular surface disease Index(OSDI)and the quality-of-life scale for Chinese patients with visual impairment(SQOL-DV1).ocular conditions and systemic conditions were also assessed.RESULTS:Eye damage was correlated with total bilirubin(P=0.005),and gamma-glutamyl transferase(GGT)(P=0.021).There was no significant correlation between the overall QOL score and OSDI(P=0.8226)or SQOLDV1(P=0.9526)scores.The OSDI and the overall QOL score were not correlated with ocular conditions,including best-corrected visual acuity(BCVA),intraocular pressure,Schirmer tear test II,sodium fluorescein staining,tear film breakup time,and tear meniscus height.SQOLDV1 was correlated with BCVA(P=0.0007),sodium fluorescein staining(P=0.007),and tear film breakup time(P=0.0146).CONCLUSION:In some patients,early ocular symptoms are not evident after ALLO-HSCT,while ocular surface complications can be observed after a comprehensive ophthalmological examination.Especially for those with elevated total bilirubin or GGT,regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease(o GVHD),especially for patients with elevated total bilirubin or GGT.

关键词： allogeneic stem cell transplantation ocular graft versus host disease ocular surface disease quality of life quality-of-life scale for Chinese patients with visual impairment ocular surface disease Index

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Inflammation and dry eye disease——where are we?

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 820-827页

作者： Srinivas K Rao Rishi Mohan Nikhil Gokhale Himanshu Matalia Paras Mehta Darshan Eye Care&Surgical Centre ChennaiTamil NaduIndia MM Eyetech Institute of Ophthalmology New DelhiIndia Gokhale Eye Hospital MumbaiMaharashtraIndia Narayana Nethralaya Electronic CityBangaloreKarnatakaIndia Sameep Eye Hospital and Corneal Center VadodaraGujaratIndia

The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear dysfunction.It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease.This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed.

关键词： dry eye disease inflammation meibomian gland dysfunction vicious cycle ocular surface disease

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Pterygium associated with light-emitting diode use:a case report

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Annals of Eye Science 2022年第4期7卷 65-68页

作者： Fiona S.Lau Stephanie L.Watson Kenneth Gek-Jin Ooi Ophthalmology Department Prince of Wales HospitalRandwickNSWAustralia Faculty of Medicine School of Medical SciencesUniversity of New South WalesRandwickNSWAustralia Cornea Unit Sydney Eye HospitalSydneyNSWAustralia Save Sight Institute Discipline of OphthalmologySydney Medical SchoolThe University of SydneySydneyNSWAustralia Sydney Eye Clinic DarlinghurstNSWAustralia

Background:Pterygium is a sun-related ocular surface disease secondary to ultraviolet(UV)radiation exposure.Outdoor occupational UV exposure is known to occur secondary to sun exposure.We present a unique case of pterygium associated with indoor occupational light-emitting diode(LED)exposure not previously described in the literature.Case Description:A mobile phone repairer presented with blurred vision and a superotemporal pterygium of his dominant left eye associated with a magnifying glass LED work lamp was diagnosed.This was excised routinely with conjunctival autografting to the defect.Histopathology confirmed benign pterygium and recovery was uncomplicated with resolution of blur.Conclusions:The development of pterygium in our patient may have arisen due to the LED lamp’s wavelengths possibly falling within the UV as well as the upper end of the visible light radiation spectrum.Given the increasing reliance on LED light sources in modern life,ocular conditions arising from exposure to these radiation sources may now need to be listed in the differential diagnoses of patients with pterygium.Appropriate UV protection counselling for these types of lights may also now need to be considered.

关键词： Pterygium light-emitting diode(LED) ultraviolet light damage ocular surface disease case report

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Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 730-737页

作者： Qin Long Ya-Gang Zuo Xue Yang Ting-Ting Gao Jie Liu Ying Li Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

AIM： To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy（IVCM） in patients with ocular cicatricial pemphigoid（OCP）.· METHODS： A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. The results of direct immunofluorescence（DIF） biopsies and indirect immunofluorescence（IIF） were also recorded. Local and systemic immunosuppressive therapy were administered and adjusted according to response.·RESULTS： A total of 12 consecutive OCP patients（7male, 5 female; mean age 60.42 ±10.39y） were recruited.All patients exhibited bilateral progressive conjunctival scarring and recurrent chronic conjunctivitis was the most frequent clinical pattern. The mean duration of symptoms prior to diagnosis of OCP was 2.95 ±2.85y（range： 5mo to 10y）. The Foster classification varied from stage I to IV and 20 eyes（83%） were within or greater than Foster stage Ⅲ on presentation. Two of the 12patients（17%） demonstrated positive DIF; 3 of the 12（25%） patients reported positive IIF. The mean duration of the follow-up period was 20.17 ±11.88mo（range： 6 to48mo）. IVCM showed variable degrees of abnormality in the conjuctiva-cornea and conjuctival scarring was detected in all the involved eyes. Corneal stromal cell activation and dendritic cell infiltration presented asocular surface inflammation, ocular surface keratinization along with the destroyed Vogt palisades was noted in eyes with potential limbal stem cell deficiency. After treatment, remission of ocular surface inflammation was achieved in all the patients, 18 eyes（75%） remained stable, 6 eyes（25%） had recurrent conjunctivitis and cicatrization in 2 eyes（8%） was progressing.· CONCLUSION： As an autoimmune disease, OCP manifests as variable degrees of clinical and laboratory abnormalities with both local and systemic immunosuppressive treatment playing important roles in disease therapy. IVCM can be as a valuable non-invasive techni

关键词： ocular cicatricial pemphigoid ocular surface disease in vivo confocal microscopy

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