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ocular development in children with unilateral congenital cataract and persistent fetal vasculature

International Journal of Ophthalmology(English edition) 2022年第3期15卷 426-431页

作者： Shu-Yi Zhang Hui Chen Jing-Hui Wang Wan Chen Qi-Wei Wang Jing-Jing Chen Xiao-Shan Lin Zhuo-Ling Lin Duo-Ru Lin Hao-Tian Lin Wei-Rong Chen State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM: To investigate the ocular development of patients who had unilateral congenital cataract(CC) combined with persistent fetal vasculature(PFV).METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral *** length(AL), keratometry, anterior chamber depth(ACD), lens thickness, and vitreous length were *** ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated ***: A total of 110 patients were included and divided into 4 groups: group 1(18 patients with CC and PFV, 0.05).CONCLUSION: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24 mo and longer in those older than 24 mo;the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24 mo and similar with those younger than 24 *** findings provide further understanding of ocular development in patients with both CC and PFV.

关键词： ocular development congenital cataract persistent fetal vasculature axial length keratometry

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Molecular aspects of eye development and regeneration in the Australian redclaw crayfish,Cherax quadricarinatus

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Aquaculture and Fisheries 2019年第1期4卷 27-36页

作者： Tomer Ventura Michael J.Stewart Jennifer C.Chandler Bronwyn Rotgans Abigail Elizur Alex W.Hewitt GeneCology Research Centre Faculty of ScienceHealthEducation and EngineeringUniversity of the Sunshine CoastSunshine CoastQueensland 4556Australia Lions Eye Institute University of Western AustraliaPerthWestern Australia 6330Australia School of Medicine Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTasmania 7005Australia

The compound eye evolved over 500 million years ago and enables mosaic vision in most arthropod *** molecular regulation of the development of the compound eye has been primarily studied in the fruit fly Drosophila ***,due to the nature of holometabolous insects halting growth after their terminal metamorphosis into the adult form,they lack the capacity to ***,unlike holometabolous insects,continue to grow during adulthood,achieved through regular shedding of their exoskeleton,in a cyclic process known as *** therefore offers crustaceans as a highly suitable model to study ocular regeneration in the adult arthropod *** have assessed the regenerative capacity of the retinal section of the Cherax quadricarinatus(red-claw crayfish)eye,following ablation and successive post-metamorphic *** work then provides a transcriptomic description of the outer,pigmented retinal tissue(the ommatidia and lamina ganglionaris)and the basal,non-pigmented neuroendocrine ocular tissue(the X-organ Sinus Gland complex,hemiellipsoid body and optic nerve).Using comparative analysis,we identified all the transcripts in the *** ocular transcriptome that are known to function in compound eye development in *** and uniquely transcribed genes of the retina are described,suggesting proposed mechanisms that may regulate ocular regeneration in decapod *** research exemplifies the application *** holds as an optimal model to study the regulation of ocular *** in-depth transcriptomic analyses are now required,sampled throughout the regeneration process to better define the regulatory mechanism.

关键词： ocular development Regeneration Compound eye Crustacean Cherax quadricarinatus Transcriptome

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