检索结果-南通市图书馆

Feasibility of cabazitaxel in octogenarian prostate cancer patients

Current Urology 2023年第3期17卷 153-158页

作者： Paolo Tralongo Sebastiano Bordonaro Giuseppe Di Lorenzo Ugo De Giorgi NicolòBorsellino Gaetano Facchini Sabrina Rossetti Giuseppe Fornarini Vito Longo Antonino Carmelo Tralongo Francesca Caspani Massimiliano Spada Nicola Calvani Paolo Carlini Medical Oncology Unit RAO-Umberto I HospitalSiracusa96100Italy Department of Medicine and Health Sciences‘Vincenzo Tiberio' University of MoliseCampobassoItaly Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(IRST)IRCCS Meldola(FC)Italy Medical Oncology Unit Ospedale Buccheri La FerlaFatebenefratelliPalermoItaly Medical Oncology Unit Santa Maria delle Grazie di PozzuoliNapoliItaly Departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale TumoriIRCCSFondazione G.PascaleNapoliItaly Medical Oncology 1 IRCCSOspedale Policlinico San MartinoGenovaItaly Istituto Tumori Giovanni PaoloⅡI.R.C.C.S. BaOspedale di CircoloVareseItaly Medical Oncology Unit ASSTSETTE LAGHIOspedale di CircoloVareseItaly Medical Oncology Unit Fondazione Istituto G.Giglio di CefalùPalermoItaly Medical Oncology Division&Breast Unit Sen.A.Perrino HospitalBrindisiItaly Medical Oncology 1 Istituto Nazionale Tumori Regina ElenaRomaItaly

Background:To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged>80 years,we performed a retrospective study on a sample of patients from 11 Italian cancer *** and methods:Fifty-seven patients aged>80 years were treated with cabazitaxel after previous failure with docetaxel;39 completed a comprehensive geriatric assessment questionnaire(34 fit and 5 vulnerable)and 8 patients(14%)had an Eastern Cooperative Oncology Group performance status(PS)>2,while most had a PS of 0-1(86%).Cabazitaxel was administered at a dose of 25 mg/m^(2)in 30(52%)patients and 20 mg/m^(2)or adapted schedules in 27(48%)*** schedules were adopted mainly in patients>85 years(75%),with a PS>2(87.5%),and those classified as vulnerable(100%).Results:The duration of treatment was 4.8 months and was comparable in all subgroups;disease control rate was reported in 36 patients(63%);prostate-specific antigen response was recorded in 18 patients(31.5%).Median overall survival was 13.1 months regardless of age(85 years),but overall survival was reduced in vulnerable(7.2 months)and PS>2 patients(6.8 months).The most frequently documented grade 3-4 toxicities were neutropenia(14%)and diarrhea(10.5%).Six patients(10.5%)dropped out due to severe ***:octogenarian patients can be treated with cabazitaxel with reduced doses or alternative schedules that are associated with less toxicity and fewer treatment *** geriatric assessment could facilitate more appropriate patient selection.

关键词： Cabazitaxel Cancer octogenarian Prostate

来源：评论

学校读者我要写书评

暂无评论

octogenarian PARTY MEMBER

引用

Beijing Review 2018年第27期61卷 10-11页

Nlu Ben, an 83-year-old actor, was encouraged by President Xi Jinping to play a vanguardand exemplary rote as a member of the Communist Party of China （CPC） in a letter on June25.

关键词： octogenarian PARTY MEMBER CPC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Random forests to predict survival of octogenarians with brain metastases from nonsmall-cell lung cancer

引用

Brain Science Advances 2024年第1期10卷 39-56页

作者： Lijun Song Yu Wang Xue Li Yi Liu Bingyi Yin Daorui Li Hongsheng Lin Yuqi Zhang Department of Neurosurgery Yuquan HospitalTsinghua UniversityBeijing 100040China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

Background:To create and validate nomograms for the personalized prediction of survival in octogenarians with newly diagnosed nonsmall-cell lung cancer(NSCLC)with sole brain metastases(BMs).Methods:Random forests(RF)were applied to identify independent prognostic factors for building nomogram *** predictive accuracy of the model was evaluated based on the receiver operating characteristic(ROC)curve,C-index,and calibration ***:The area under the curve(AUC)values for overall survival at 6,12,and 18 months in the validation cohort were 0.837,0.867,and 0.849,respectively;the AUC values for cancer-specific survival prediction were 0.819,0.835,and 0.818,*** calibration curves visualized the accuracy of the ***:The new nomograms have good predictive power for survival among octogenarians with sole BMs related to NSCLC.

关键词： octogenarian NSCLC brain metastases random forests nomogram

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical efficacy of different treatments and their impacts on the quality of life of octogenarians with coronary artery disease

引用

Chinese Medical Journal 2019年第22期132卷 2657-2663页

作者： Xiang-Yu Wu Tao Ying Cheng-Qian Yin Su Wang Yu-Long Gao Yu-Tong Cheng Zhao Li Zhi-Zhong Li Department of Cardiology Ward 5 Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Background:Coronary artery disease(CAD)in octogenarians(age of>80 years)has a high risk of mortality and high *** shows that the prevalence of CAD is higher among octogenarians than that among younger people,but few such patients undergo percutaneous coronary intervention(PCI)or coronary artery bypass grafting(CABG).This study aimed to evaluate different treatments w让h respect to their clinical effects and impacts on quality of life of octogenarians with ***:Data of 519 octogenarians with CAD consecutively treated at Beijing Anzhen Hospital,Capital Medical University(Beijing,China)from January 2010 to January 2016 were collected in this *** patients were categorized into three groups based on the treatments they received:the PCI group(n=292),CABG group(n=110),and medical treatment group(n=117).The followings were recorded during follow-up:clinical data,death(all-cause and cardiovascular-related),re-hospitalization time,Seattle Angina Questionnaire(SAQ)score,and occurrence of hemorrhagic events(cerebral bleeding,gastrointestinal bleeding,and dermal ecchymosis).Results:The median follow-up duration was 25.0(25th,75th percentile:17.0,55.5)months among 417 *** all-cause death rates(28.2%vs.12.0%and 14.6%,respectively)and cardiovascular-related death rates(15.4%us.3.8%and 6.4%,respectively)were significantly higher in the medical treatment group than those in the PCI group and CABG group(all P<0.05).The re-hospitalization rate for cardiovascular events was significantly lower in the CABG group than those in the PCI group and medical treatment group(3.8%vs.12.8%and 14.9%,respectively)(x^2=8.23&P=0.018).The SAQ scores of physical limitation,angina frequency,treatment satisfaction,and disease perception were significantly higher in the PCI group and CABG group than those in the medical treatment group(all P<0.05).No significant difference in the angina stability score was observed among the three groups(F=3.179,P=0.204).Conclusion:PCI an

关键词： Coronary artery disease octogenarian Percutaneous coronary intervention Coronary artery bypass graft Death Life quality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of long stent implantation in diffuse coronary lesions for octogenarians

引用

Journal of Geriatric Cardiology 2005年第1期2卷 29-35页

作者： Osamu Katoh Shigeru Nakamura Cardiovascular Center Kyoto Katsura Hospital 17 Yamada Hirao-choNishikyo-kuKyoto 615-8256Japan

Objective To evaluate angiographic and clinical outcomes of ≥ 20mm long stents or overlapped stent implantation in diffuse coronary lesions for octogenarians, in comparison with patients under sixty. Methods Two groups (Group O: 47 lesions in 44 octogenarians, aged 81± 3 years; Group Y: 64 lesions in 58 patients under sixty, aged 54 ± 4 years) were compared with a 6-month follow-up. Results Success rate of the procedures was 100%. None had in-hospital major adverse cardiac events (MACE). There was no significant difference in angiographic restenosis between the groups at follow-up (Group O vs Group Y, 29.8 % vs 26.6 %, P = NS). The revascularization of target vessel and MACE was less in Group Y, but these showed no statistical significance (15.6% vs 23.4% and 20.7% vs 25.0%, respectively). Conclusions Long stent implantation for diffuse coronary lesions in octogenarians appears safe and feasible, with high procedural success and favorable long-term outcomes.

关键词： percutaneous coronary intervention octogenarian diffuse lesion coronary stenting follow-up

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Outcomes of elective laparoscopic colorectal operations in octogenarians at a district general hospital in South East England

引用

World Journal of Gastrointestinal Surgery 2013年第1期5卷 9-11页

作者： Roland Fernandes Irshad Shaikh Samer Doughan Deparment of Colorectal Surgery Queen Elizabeth The Queen Mother HospitalMargate CT9 4ANUnited Kingdom

AIM:To assess the outcomes of laparoscopic colorectal cancer resection in the octogenarian population at our ***:Retrospective analysis of registry data accumulated prospectively were used in conjunction with the data obtained from patient notes to identify outcome data for octogenarians who had undergone elective laparoscopic colorectal cancer ***:Laparoscopic colorectal cancer resections were performed in 68 octogenarians between 2003 and 2011 at our *** operations(6%) were converted to an open *** were twelve cases of morbidity(18%) and two cases of mortality(3%).The overall median hospital stay was 8 *** median time for a patient to be deemed surgically fit for discharge was 5 d reflecting a delay in provision of social care or stoma ***:Our results support the view that laparoscopic surgery in octogenarians is safe,feasible and with a reduced length of *** is well reflected in our results which are compatible with United Kingdom national figures.

关键词： Laparoscopic surgery Colorectal disease octogenarian Mortality Morbidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of age on long term survival following transcatheter aortic valve implantation

引用

Journal of Geriatric Cardiology 2019年第3期16卷 265-271页

作者： Nuray Kahraman Ay Department of Cardiology Bezmialem Vakif University

Objective To compare the long-term survival following transcatheter aortic valve implantation (TAVI) in an octogenarian population with that in a younger *** This retrospective study included 274 patients that underwent TAVI for severe symptomatic aortic *** study group was divided into two age groups,as those with an age ≥ 80 years (octogenarians,n = 132),and age < 80 (younger patients,n = 142).The two groups were compared in terms of clinical outcomes and *** addition,significant predictors of survival were *** Non-cardiac mortality (during follow-up)(21.9% vs.10.5%,P = 0.01) and in-hospital stroke (8.3% vs.2.8%,P = 0.01) were more common among *** two groups did not differ in terms of mean survival (41.0 ± 2.1 vs.38.2 ± 2.2 months,respectively,P =0.18).Multivariate analysis identified left ventricular ejection fraction < 35%(OR: 2.17,95% CI: 1.17–4.03;P = 0.01),preoperative of moderate to severe mitral insufficiency (OR: 1.88,95% CI: 1.15–3.06;P = 0.01),postoperative major and life-threating bleeding (OR: 2.49,95% CI: 1.05–5.89;P =0.03),and in-hospital stroke (OR: 2.29,95% CI: 1.04–5.04;P = 0.03) as potential predictors of poor *** In this study,similarly favorable survival outcomes were achieved in the elderly population as in younger patients,despite the presence of comorbid conditions.A consideration should be given to non-surgical management of severe aortic stenosis with the TAVI procedure in elderly patients,in the absence of co-existent conditions associated with shortened life expectancy.

关键词： Aortic stenosis Clinical outcome Non-surgical management octogenarian The elderly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between Physical Inactivity and Long-term Outcome in Patients Aged ≥80 Years with Acute Coronary Syndrome

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 64-69页

作者：李世军 Salim Barywani Michael FU Section of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Section of Cardiology Department of MedicineSahlgrenska University Hospital/Ostra Hospital Gothenburg Sweden

Physical inactivity is very common in ***,association between physical inactivity and mortality in octogenarians with acute coronary syndrome（ACS） remains *** this study,we aimed to investigate association between physical inactivity and allcause mortality in octogenarian patients with *** this study,we included a total of 353 hospitalized patients,aged ≥80 years,with ACS during the period of 5-year *** association between physical inactivity and all-cause mortality was analyzed by multivariable Cox *** the enrolled patients,132（37.4%） were defined as physically inactive,and 221（62.6%） as physically *** with physical inactivity tended to have lower survival rate（21.2% vs.56.5%,P〈0.001） and higher mortality rate（78.8% vs.43.5%,P〈0.001）,and had a worse long-term outcome than those with physical activity（chi-square=27.52,and log rank P〈0.001）.The physical inactivity was still an independent predictor for long-term allcause mortality independent of confounders including age,prior heart failure,stroke,ejection fraction,beta-blocker,clopidogrel and percutaneous coronary intervention（HR：2.35,95% CI：1.26–4.37,P=0.007）.Our study demonstrates that physical inactivity is independently related to increased all-cause mortality in octogenarians with ACS.

关键词： physical inactivity octogenarian acute coronary syndrome mortality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：