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Fos expression　incatecholaminergic　medullary　neu-rons　induced　by　chemical　stimulation　of　stomach　projecting　to　the　paraventricular　nucleus　of　hypothalamus　in　rats

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World Journal of Gastroenterology 1997年第2期3卷 15-17页

作者： DONG Yuan Xiang, XIONG Kang Hui, RAO Zhi Ren and SHI Ji Wu

Ｆｏｓｅｘｐｒｅｓｓｉｏｎｉｎｃａｔｅｃｈｏｌａｍｉｎｅｒｇｉｃｍｅｄｕｌａｒｙｎｅｕｒｏｎｓｉｎｄｕｃｅｄｂｙｃｈｅｍｉｃａｌｓｔｉｍｕｌａｔｉｏｎｏｆｓｔｏｍａｃｈｐｒｏｊｅｃｔｉｎｇｔｏｔｈｅｐａｒａｖｅｎｔ... 详细信息

Ｆｏｓｅｘｐｒｅｓｓｉｏｎｉｎｃａｔｅｃｈｏｌａｍｉｎｅｒｇｉｃｍｅｄｕｌａｒｙｎｅｕｒｏｎｓｉｎｄｕｃｅｄｂｙｃｈｅｍｉｃａｌｓｔｉｍｕｌａｔｉｏｎｏｆｓｔｏｍａｃｈｐｒｏｊｅｃｔｉｎｇｔｏｔｈｅｐａｒａｖｅｎｔｒｉｃｕｌａｒｎｕｃｌｅｕｓｏｆｈ...

关键词： medulla oblongata paraventricular hypothalamic nucleus neurons immunochemistry

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Medicine in the future-with subspecialists in medullary neurology and brain dentistry

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World Journal of Neurology 2015年第4期5卷 107-112页

作者： J Howard Jaster Department of Medicine London Corporation

The solitary tract nucleus of the medulla with its limited watershed vascular capacity may occasionally be the focus of transient ischemia caused by the increased metabolic demands associated with frequent and intense neuronal stimulation from other organs and other parts of the brain. Case reports have suggested that these ischemic changes may sometimes result in the initiation of intense autonomic discharges, which can occasionally be fatal. Therapeutic interventions for the medulla oblongata are hamperedby its limited accessibility. Systemically administered pharmaceuticals may have some usefulness in future years. Previous experience with vagus nerve stimulation in the treatment of epilepsy suggests that it may have some usefulness in stabilizing medullary autonomic discharges. Computerized electronic stimulation of other cranial nerves may be helpful as well, especially the chorda tympani nerve, and may be most easily accomplished from implanted dental appliances, especially molar modules, transmitting signals via secondary transmitters procedurally placed on cranial nerves. Future technology may enable wireless signaling from the implanted dental appliance to the secondary transmitter placed at the nerve site. By the year 2050 subspecialists in medullary neurology and brain dentistry may use computerized electronic stimulation of cranial nerves to prevent sudden unexpected death and treat "chest pain from the brain".

关键词： Solitary tract nucleus Ischemic autonomic umbra Medulla oblongata Molar module Chorda tympani nerve Medullary brain lesion Medullary neurology Chest pain from the brain Sudden unexpected death Brain dentistry Vagus nerve stimulation

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Neuroprotection by Melatonin on Mercury Induced Toxicity in the Rat Brain

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Pharmacology & Pharmacy 2011年第4期2卷 375-385页

作者： Mandava V. Rao Anshita R. Purohit 不详

Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants and overproduction or incorporation of free radicals from environment to living systems leads to serious damage. It also attacks nervous system resulting in neural-degeneration. In order to evaluate the neurotoxic effect on the brain parts of mercury in our study, oxidative stress indices of enzymatic and non enzymatic components were measured in rats intoxicated with mercury (2 mg and 4 mg/kg body weight) for 60 days to adult rats. Along with gravimetry, tissue burden was also recorded. Alterations in these indices were further supported by ultrastructural studies carried out in the brain as indicated by myelin disintegration, cell organelle alterations and neuronal loss by mercury poisoning. Treatment with the antioxidant melatonin (N-acetyl 5-methoxy tryptamine, 5 mg/kg) prevented mercury exerted toxicity due to its antioxidant property. The pathological changes were also ameliorated in the brain region comparatively to support biochemical profile of brain. Thus, melatonin produced neuroprotection against mercury poisoning in rats.

关键词： Mercuric Chloride Melatonin Neuroprotection Cerebral Hemisphere Cerebellum Medulla oblongata Rats

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