检索结果-南通市图书馆

Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

Bioactive Materials 2024年第3期33卷 396-423页

作者： Ravi Raj Singh Indranil Mondal Taskeen Janjua Amirali Popat Ritu Kulshreshtha Department of Biochemical Engineering and Biotechnology Indian Institute of Technology DelhiNew DelhiIndia School of Pharmacy The University of QueenslandBrisbaneQLD4072Australia Department of Functional Materials and Catalysis Faculty of ChemistryUniversity of ViennaWahringer Straße 421090 ViennaAustria University of Queensland-IIT Delhi Academy of Research(UQIDAR)

Glioblastoma(GBM)is an aggressive malignancy of the central nervous system(CNS)that remains incurable despite the multitude of improvements in cancer *** conventional chemo and radiotherapy post-surgery have only been able to improve the prognosis slightly;however,the development of resistance and/or tumor recurrence is almost *** is a pressing need for adjuvant molecular therapies that can successfully and efficiently block tumor *** the last few decades,non-coding RNAs(ncRNAs)have emerged as key players in regulating various hallmarks of cancer including that of *** levels of many ncRNAs are dysregulated in cancer,and ectopic modulation of their levels by delivering antagonists or overexpression constructs could serve as an attractive option for cancer *** therapeutic potential of several types of ncRNAs,including miRNAs,lncRNAs,and circRNAs,has been validated in both in vitro and in vivo models of ***,the delivery of these RNA-based therapeutics is highly challenging,especially to the tumors of the brain as the blood-brain barrier(BBB)poses as a major obstacle,among ***,since RNA is extremely fragile in nature,careful considerations must be met while designing a delivery *** this review we have shed light on how ncRNA therapy can overcome the limitations of its predecessor conventional therapy with an emphasis on smart nanomaterials that can aide in the safe and targeted delivery of nucleic acids to treat ***,critical gaps that currently exist for successful transition from viral to non-viral vector delivery systems have been ***,we have provided a perspective on the future directions,potential pathways,and target areas for achieving rapid clinical translation of,RNA-based macromolecular therapy to advance the effective treatment of GBM and other related diseases.

关键词： Glioblastoma(GBM) Non-coding RNAs(ncRNA) nucleic acid therapy Oligonucleotide therapy Nanocarriers Nanoparticles RNA delivery system Gene therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Albumin-based nanoparticles: a promising strategy to overcome cancer drug resistance

引用

Cancer Drug Resistance 2020年第4期3卷 930-946页

作者： Islam Hassanin Ahmed Elzoghby Department of Biotechnology Institute of Graduate studies and ResearchAlexandria UniversityAlexandria 21526Egypt Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt Department of Industrial Pharmacy Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Circumvention of cancer drug resistance is one of the major investigations in *** this regard,nanotechnology-based drug delivery has offered various ***,protein-based nanocarriers have been a versatile choice compared to other nanomaterials,provided by their favorable characteristics and safety ***,albumin-based nanoparticles have been demonstrated to be an effective drug delivery system,owing to the inherent targeting modalities of albumin,through gp60-and SPARC-mediated receptor ***,surface functionalization was exploited for active targeting,due to albumin’s abundance of carboxylic and amino ***-responsive drug release has also been pertained to albumin ***,albumin-based nanocarriers could potentially overcome cancer drug resistance through bypassing drug efflux,enhancing drug uptake,and improving tumor ***,albumin nanocarriers improve the stability of various therapeutic cargos,for instance,nucleic acids,which allows their systemic *** review highlights the recent applications of albumin nanoparticles to overcome cancer drug resistance,the nano-fabrication techniques,as well as future perspectives and challenges.

关键词： Albumin active targeting cancer therapy drug delivery multi-drug resistance nanoparticles stimuliresponse release nucleic acid therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：