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Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats

International Journal of Ophthalmology(English edition) 2015年第4期8卷 665-669页

作者： Guo-Ling Chen Jing-Jing Zhang Xin Kao Lu-Wan Wei Zhi-Yu Liu Department of Ophthalmology the Second Hospital of Shandong University Department of Ophthalmology the Third People's Hospital of Jinan Department of Anatomy Shandong Univeristy School of Medicine

· AIM: To investigate the effect of emodin on pseudomonas aeruginosa lipopolysaccharides(LPS)-induced corneal inflammation in rats.· METHODS: Corneal infection was induced by pseudomonas aeruginosa LPS in Wistar rats. The inflammation induced by LPS were examined by slit lamp microscope and cytological checkup of aqueous *** tissue structure was observed by hematoxylin and eosin(HE) staining. The activation of nuclear factor kappa b(NF-κb) was determined by Western *** ribonucleic acid(m RNA) of tumor necrosis factor-α(TNF-α) and intercellular adhesion molecule-1(ICAM-1) in LPS-challenged rat corneas were measured with reverse transcription-polymerase chain reaction(RT-PCR).· RESULTS: Typical manifestations of acute corneal inflammation were observed in LPS-induce rat model,and the corneal inflammatory response and structure were improved in rats pretreated with emodin. Treatment with emodin could improve corneal structure, reduce corneal injure by reducing corneal inflammatory response. Emodin could inhibit the decreasing lever of inhibitor of kappa b alpha(Iкbα) express, and the m RNA expression of TNF-α and ICAM-1 in corneal tissues was also inhibited by emodin. The differences were statistically significant between groups treated with emodin and those without treatment(P biting the activation of NF-κb.

关键词： nuclear factor kappa b inhibitor alpha therapy inflammation

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