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nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.

Frigid Zone Medicine 2022年第2期2卷 103-108页

作者： Yan Liu Xiaohui Rong Yuanhang Chang Juan Pan Wei Guan Haixue Kuang Bingyou Yang Key Laboratory of Basic and Application Research of Beiyao(Heilongjiang University of Chinese Medicine) Ministry of EducationHarbin 150040China Key Laboratory of Forest Plant Ecology Ministry of EducationNortheast Forestry UniversityHarbin 150040China

Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(***)has been found to contain bioactive components similar to the fruit of ***,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of ***:The chemical components of ethyl acetate extract from 70%ethanol extract from *** fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of *** isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,***:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of *** for the first *** them,compounds 6-8 showed significant anti-gastric cancer *** postulated that the fruit stalk of *** could be used as an anti-gastric cancer drug.

关键词： nortriterpenoids Schisandra chinensis(Turcz.)Baill. fruit stalk cytotoxicity MGC-803 cells

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