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Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities

Natural Products and Bioprospecting 2011年第1期1卷 33-36页

作者： Guang-Yu YANG Yin-Ke LI Xing-Jie ZHANG Xiao-Nian LI Liu-Meng YANG Yi-Ming SHI Wei-Lie XIAO Yong-Tang ZHENG Han-Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Key Laboratory of Tobacco Chemistry of Yunnan Province Yunnan Academy of Tobacco ScienceKunming 650106YunnanChina School of Chemistry and Biotechnology Yunnan Nationalities UniversityKunming 650031YunnanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunnanChina

Three new highly oxygenated nortriterpenoids,wilsonianadilactones D-F(1-3),were isolated from the leaves and stems of Schisandra *** structures were established by means of spectroscopic *** 1-3 showed weak anti-HIV-1... 详细信息

关键词： nortriterpenoid wilsonianadilactone Schisandra wilsoniana

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Limonoids from seeds of Azadirachta indica ***. and their cytotoxic activity

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Acta Pharmaceutica Sinica B 2018年第4期8卷 639-644页

作者： Jian Chen Xiaona Fan Jianhua Zhu Liyan Song Zhiwei Li Fei Lin Rongmin Yu Hanhong Xu Jiachen Zi Biotechnological Institute of Chinese Materia Medica Jinan University School of Life Sciences Sun Yat-Sen University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural University

Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin(1), 28-deoxo-2,3-dihydronimbolide(2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin(3) and 12-acetoxy-3-Oacetyl-7-O-methacryloylvilasinin(4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 7.68±1.74 μmol/L, and 5 inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC_(50) 12.00±2.08, 17.44±2.11, and 13.95±5.74 μmol/L, respectively.

关键词： Azadirachta indica nortriterpenoid Limonoid Spectroscopy Cytotoxic activity

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Terpenes from Schisandra sphenanthera

Terpenes from Schisandra sphenanthera

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2010年全国中药学术研讨会

作者： Yan Jiang~a,Zhi-Nan Mei~a,Guang -Zhong Yang~(*a),Mao-Chuan Liao~a,Yu Chen~b a Laboratory for Natural Product Chemistry,College of Pharmacy,South Central University for Nationalities,Wuhan 430074,P.R.China b College of Chemistry and Material Sciences,South Central University for Nationalities,Wuhan 430074,P.R.China

One novel highly oxygenated nortriterpenoid,schintrilactone C,and four known compounds,were isolated from the rattan of Schisandra *** structures were determined by analysis of 1D and 2D NMR spectroscopic *** C is the third example of Wuweiziartane-type skeleton nortriterpenoids,bearing a modified five-membered D ring and aδ-lactone E ring and a spirocyclic moiety at the C(13) side chain.

关键词： Schisandra sphenanthea Terpene nortriterpenoid Schintrilactone

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