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Clinical and Laboratory Characteristics of Patients with nontuberculous mycobacterium Bloodstream Infection in a Tertiary Referral Hospital in Beijing, China

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Chinese Medical Journal 2016年第18期129卷 2220-2225页

作者： Sai-Nan Bian Li-Fan Zhang Yue-Qiu Zhang Qi-Wen Yang Peng Wang Ying-Chun Xu Xiao-Chun Shi Xiao-Qing Liu Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Clinical Epidemiology Unit International Epidemiology Network Peking Union Medical College Beijing 100730 China Laboratory Department Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： nontuberculous mycobacterium （NTM） bloodstream infection （BSI） is relatively rare. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with NTM BSI. Methods： We retrospectively reviewed the clinical records of inpatients with NTM BSI at our institution between January 2008 and January 2015 and recorded clinical parameters including age, gender, underlying disease, clinical manifestation, organs involved with NTM disease, species of NTM, laboratory data, treatment and outcome of these patients. We also reviewed the reported cases and case series ofNTM BSI by searching PubMed, EMBASE, and Wanfang databases. Data of normal distribution were expressed by mean ~ standard deviation （SD）. Data of nonnormal distribution were expressed by median and interquartile range （IQR）. Results： Among the ten patients with NTM BSI, the median age was 51 years （IQR 29-57 years） and three patients were males. Eight patients were immunocompromised, with underlying diseases including human immunodeficiency virus （HIV） infection （one patient）, rheumatic diseases （two patients）, breast cancer （one patient）, myelodysplastic syndrome （two patients）, and aplastic anemia （two patients）. Other organ（s） involved were lung （two patients）, endocardium （two patients）, brain, spinal cord, and soft tissue （one each patient）. The median lymphocyte was 0.66 x 109/L （IQR 0.24-1 .93 × 10^9/L）. The median cluster of differentiation 4 （CD4） cell count was 179/ mm^3 （IQR 82-19/mm^3）. Five patients died （three with hematological diseases, one with breast cancer, and one with rheumatic disease）, three recovered, and two were lost to follow-up. Conclusions： We reported all cases in our hospital diagnosed with bloodstream NTM infection that was rarely reported. In this group of patients, patients usually had a high fever and could have multiple organ involvements. All patients with poor prognosis had underlying diseases.

关键词： Bloodstream Infection Hematogenous Disseminated nontuberculous mycobacterium

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Bilateral nontuberculous mycobacterial keratitis after laser in situ keratomileusis

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Chinese Medical Journal 2007年第21期120卷 1935-1937页

作者： LIANG Qing-feng SUN Xu-guang LI Ying WANG Zhi-qun LUO Shi-yun LI Ran Department of Ocular Microbiology Beijing Institute of Ophthalmology Beijing Tong Ren Hospital Capital Medical University Beijing 100005 China Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Laser in situ keratomileusis （LASIK） is currently the most popular keratorefractive procedure performed worldwide with generally excellent outcomes. However, infectious keratitis after LASIK is a devastating, vision-threatening complication. The common pathogens were bacteria and fungi. nontuberculous mycobacterium （NTM） accounted for a substantial proportion of these pathogens. Most NTM infections （86% of cases） were involved in unilateral cornea. In this study, we report six patients with bilateral NTM keratitis following LASIK.

关键词： laser in situ keratomileusis nontuberculous mycobacterium keratitis

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Anti-programmed death 1 antibody in the treatment of coexistent mycobacterium fortuitum and lung cancer: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3801-3807页

作者： Cui-Cui Zhang Peng Chen Department of Thoracic Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND nontuberculous mycobacterium(NTM) refers to all mycobacteria except mycobacterium tuberculosis and mycobacterium leprae, also known as environmental mycobacterium. The patients with lung cancer and NTM are somewhat special;the two diseases are inevitably influenced by each other. It brings difficulties and challenges to the choice of treatment. Recently, cancer immunotherapy has been considered one of the pillars for the treatment of lung cancer. However, the clinical experience in the application of immune checkpoint inhibitors is scarce for lung cancer patients with pulmonary tuberculosis, and lung cancer with NTM is even more rare. Although it ameliorates lung cancer, immunotherapy with immune checkpoint inhibitors presents complications of infectious diseases, including tuberculosis and *** SUMMARY A 61-year-old male patient visited a doctor in May 2019. His admitting diagnoses were:(1) Cancer of the left lung with a pathological diagnosis of poorly differentiated non-small cell carcinoma, likely poorly differentiated adenocarcinoma, clinical stage Ⅲb(T3N3M0);and(2) mycobacterium fortuitum(M. fortuitum) infection. We chose to proceed with pembrolizumab treatment. After two treatment cycles, a chest computed tomography scan showed a new irregular subpleural mass in the anterior segment of the left upper lobe of the lung, a reduction in the mediastinal enlarged lymph node, and no other obvious changes. Next, an ultrasound-guided biopsy of the new tumor was performed. Pathological examination showed that a large number of carbon particles were deposited in the alveolar tissue with histiocyte reaction and multinucleated giant cell formation. The tuberculosis(TB) specialist suggested that anti-TB therapy be combined with continued antitumor treatment. The patient continued to be treated with pembrolizumab. After 14 cycles, the lesion shrunk by 79%, there was no recurrence of M. fortuitum infection, and there were no intolerable adverse ***

关键词： mycobacterium fortuitum nontuberculous mycobacterium Non-small cell lung cancer Immune checkpoint inhibitors Case report

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mycobacterium abscessus infection after facial injection of argireline:A case report

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World Journal of Clinical Cases 2021年第8期9卷 1996-2000页

作者： Chao-Feng Chen Jie Liu Shuang-Shuang Wang Yu-Fang Yao Bo Yu Xiao-Ping Hu Department of Dermatology&Venereology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND The incidence of infection with mycobacterium abscessus(***)has increased in recent *** increase is partly associated with invasive cosmetic *** SUMMARY The purpose of this case summary is to increase clinicians'awareness of *** infection and reduce mycobacterial infection caused by cosmetic *** report the case of a 45-year-old woman who received acetyl hexapeptide-8(argireline)injections in the forehead and temples,and erythema,nodules,and abscesses appeared at the injection sites after one *** pus specimens were examined by microbiological culture and confirmed to be positive for *** 500 mg twice daily and moxifloxacin 400 mg once daily were administered for 5 mo and the lesions gradually *** We report here for the first time a case of infection with *** after argireline *** condition is easily misdiagnosed as a common bacterial *** examinations are helpful for diagnosis and standardized cosmetic procedures can prevent infection with ***.

关键词： Argireline mycobacterium abscessus nontuberculous mycobacterium Infection Injection Antibiotic therapy Case report

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