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Ginsenoside 3β-O-Glc-DM(C3DM) Enhances the Antitumor Activity of Taxol on Lewis lung cancer by Targeting the Interleukin-6/Jak2/STAT3 and Interleukin-6/AKT Signaling Pathways

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 432-440页

作者： Mei Tang Lu-Lu Huang Qian-Qian Du Chen Yan An-Di Gu Jin-Ling Yang Yan Li Department of Pharmacology Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Department of Pharmacology Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Department of Biosynthesis State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning CommissionInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Objective:nonsmall-cell lung cancer(NSCLC)is an aggressive,highly chemoresistant *** is an effective chemotherapeutic drug widely used for the treatment of ***,the clinical use of Taxol is limited due to the occurrence of adverse side effects under high therapeutic ***,it is desirable to explore combination therapy to reduce the dose of chemotherapeutic drugs and achieve excellent outcomes.A biosynthetic ginsenoside,3-O-β-D-glucopyranosyl-dammar-24-ene-3β,20 S-diol(3β-O-Glc-DM,C3 DM)is obtained from microbial fermentation by metabolic *** on previous study findings,we aimed to explore the mechanism of combination therapy with C3 DM and Taxol and its increasing antitumor effect on Lewis lung cancer(LLC)in this *** and Methods:A thiazolyl blue tetrazolium bromide(MTT)assay was performed to evaluate cell viability;the apoptotic effect was studied using cell apoptosis *** Lewis tumor xenograft experiment was performed to determine the effects of C3 DM combined with Taxol on tumor growth in vivo,and western blotting was performed to analyze protein ***:C3 DM effectively inhibited the proliferation of NSCLC ***,C3 DM increased the antiproliferative activity of Taxol and significantly enhanced cell apoptosis induced by Taxol in Lewis lung cancer cells.C3 DM alone also suppressed Lewis tumor growth and enhanced the antitumor activity of Taxol in *** blot analysis revealed that the effects of the antiproliferation and apoptosis induction of C3 DM treatment alone or in combination with Taxol on Lewis lung cancer were mediated by inhibiting the interleukin-6(IL-6)/Jak2/STAT3 and IL-6/AKT signaling ***:The results showed that C3 DM has the potential to be used in combination therapy with Taxol against NSCLC.

关键词： Combination therapy enhancing antitumor activity ginsenoside C3DM nonsmall-cell lung cancer paclitaxel

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