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Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure

Neural Regeneration Research 2013年第27期8卷 2566-2572页

作者： Yinxu Wang Xiaoming Wang Sha Ke Juan Tan Litian Hu Yaodan Zhang Wenjuan Cui Department of Neurology Affiliated Hospital of North Sichuan Medical College

Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alographic parameters in rats with chronic epilepsy and explored the mechanism underlying repeti-tive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was estab-lished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. nonlinear elec-electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.

关键词： neural regeneration repetitive transcranial magnetic stimulation electroencephalogram nonlinearanalysis nonlinear parameters epilepsy epileptic seizure epileptic discharge grant-supportedpaper neuroregeneration

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Experimental study of wave propagation characteristics on a simplified coral reef

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Journal of Hydrodynamics 2020年第2期32卷 385-397页

作者： Jia-yi Xu Shu-xue Liu Jin-xuan Li Wei Jia State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian116024China

The wave transformation over slope topography is widely studied,but most of studies are for common coastal slopes.This paper presents an experimental study of 2-D regular and irregular wave transformations on a simplified coral reef with a steep slope of 1:5 and a horizontal reef flat,focusing on the characteristics of the waves that break on the reef flat.The analyzed results show that the estimates of the wave breaking made by using the well-known previous formulae do not agree completely with the experimental results.When the waves break on a reef flat,the relative breaking wave height(H/d)b is related to the incident deep-water wave steepness and the relative water depth db/L0.Hence,a new criterion for breaking waves on a reef flat is proposed.Furthermore,in view of the fact that the local Ursell number is commonly used to parameterize the wave nonlinearity,the relationships among the skewness,the asymmetry,and the local Ursell number are also presented.Experimental data confirm that when the Ursell number is greater than 30,the absolute values of the skewness and the asymmetry on a reef flat are greater than those on a steep slope.

关键词： Coral reef bathymetry wave breaking wave height attenuation representative wave parameter nonlinear parameters

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