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Efficacy of Sitagliptin on nonalcoholic fatty liver disease in High-fat-diet-fed Diabetic Mice

Current Medical Science 2022年第3期42卷 513-519页

作者： Shu-tong ZHOU Wen CUI Li KONG Xun YANG Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Quality Management Zhumadian Central HospitalHuanghuai UniversityZhumadian 463000China

Objective nonalcoholic fatty liver disease(NAFLD)is a common cause of clinical liver dysfunction and an important prepathological change of liver cirrhosis.Central obesity,type 2 diabetes mellitus,dyslipidemia,and metabolic syndrome are the major risk factors for NAFLD.Sitagliptin(Sig)is a novel hypoglycemic agent that improves blood glucose levels by increasing the level of active incretin.Sig has been shown to prevent the development of fatty livers in mice on a fructose-rich diet.The purpose of this study was to observe the efficacy of Sig on NAFLD in type 2 diabetic mice.Methods The diet-induced obesity mouse model was established,and the diabetic mice were screened by an intraperitoneal glucose tolerance trial.The mice were randomly divided into four groups for 8 weeks of intervention:high-fat diet(HFD)group,Sig group,metformin(Met)group,and Sig+Met group.After the intervention,the liver function indexes as well as the blood glucose and blood lipid levels of the mice were measured.In addition,the wet weight of the liver was measured;the pathological sections of the liver tissues were stained to observe the hepatocyte fatty degeneration,inflammation,necrosis,and fibrosis;and the hepatic histological injury was recorded as the NAFLD activity score(NAS).Results Compared with the normal control group,the body weight,liver weight,blood glucose level,insulin resistance(IR),blood lipid level,and transaminase level of the mice in the HFD group were significantly increased,showing typical metabolic syndrome.After treatment with Sig and/or Met,the mice gained less weight,had lower levels of blood glucose,triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and transaminase,and had improved IR compared with the HFD group.The liver pathological NASs in the Sig group(P=0.01),Met group(P=0.028),and Sig+Met group(Pliver inflammation.In terms of fibrosis,there was no fibrosis

关键词： nonalcoholic fatty liver disease sitagliptin insulin resistance nonalcoholic fatty liver disease activity score

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