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non-arteritic anterior ischaemic optic neuropathy in Malaysia: a 5 years review

International Journal of Ophthalmology(English edition) 2011年第3期4卷 272-274页

作者： Abdulrahman Bawazir Reza Gharebaghi Adil Hussein Wan Hazabbah Wan Hitam Department of Ophthalmology School of Medical SciencesUniversiti Sains Malaysia

AIM: To evaluate the clinical presentations and visual outcomes of non-arteritic anterior ischaemic optic neuropathy (NAION).METHODS: A retrospective study was conducted involving 18 consecutive patients (20 eyes) with NAION attending Hospital Universiti Sains Malaysia from January 2005 until December ***: Most patients were Malay (94.4%),and followed by Chinese (5.6 %).The female-to-male ratio was 3.5:*** age of patients ranged from 36 to 85 years (mean,57.1 years).The main risk factors in systemic diseases were hypertension (55.5%),diabetes mellitus (44.4%),and ischaemic heart disease (11.1%).Most patients (77.8%) presented with acute loss of vision while gradual onset was in 22.3% of *** had visual acuity worse than 1/60 (80%).The most common fundoscopic findings were peripapillary splinter haemorrhage (90%),sectorial swollen optic disc (60%) and hyperemic disc (60%).During follow up,20% of the patients showed stabilization in visual acuity,and 80% showed worsening of ***: Majority of patients with NAION presented with acute poor vision involving middle-aged and elderly *** and diabetes mellitus were among the main risk factors *** can lead to permanent visual loss despite treatment.

关键词： non-arteritic anterior ischaemic optic neuropathy hypertension diabetes

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Risk factors of non-arteritic anterior ischaemic optic neuropathy and central retinal artery occlusion

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 869-876页

作者： Chu-Han Ma Cong-Yao Wang Ting-Ting Dai Ting-Ting Chen Wen-Hui Zhu Department of Ophthalmology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(CRAO)and develop a predictive diagnostic ***:The study included 37 patients with monocular NAION,20 with monocular CRAO,and 24 with ***,age,and systemic diseases were *** routine,lipids,hemorheology,carotid and brachial artery doppler ultrasound,and echocardiography were *** optic disc area,cup area,and cup-to-disc ratio(C/D)of the unaffected eye in the NAION and CRAO group and the right eye in the hypertension group were ***:The carotid artery intimal medial thickness(C-IMT)of the affected side of the CRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION *** with hypertension patients,NAION patients had higher whole blood reduced viscosity low-shear(WBRV-L)and erythrocyte aggregation index(EAI;P=0.045,0.037),and CRAO patients had higher index of rigidity of erythrocyte(IR)and erythrocyte deformation index(EDI;P=0.004,0.001).The optic cup and the C/D of the NAION group were smaller than the other two groups(P<0.0001).The diagnostic prediction model showed high diagnostic specificity(83.7%)and sensitivity(85.6%),which was highly related to hypertension,the C-IMT of the affected side,FMD,platelet(PLT),EAI,and C/***:CRAO patients show thicker C-IMT and worse endothelial function than *** and CRAO may be related to abnormal hemorheology.A small cup and small C/D may be involved in *** diagnostic nomogram can be used to preliminarily identify NAION and CRAO.

关键词： non-arteritic anterior ischaemic optic neuropathy central retinal artery occlusion risk factors diagnostic prediction model nomogram

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Imageology of internal carotid artery siphon in nonarteritic anterior ischaemic optic neuropathy

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1941-1947页

作者： Zhi-Yong Fu Hong-Yang Li Yan-Ling Wang Department of Ophthalmology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

AIM:To evaluate whether narrowing of internal carotid artery siphon(ICAS)may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy(NAION).METHODS:Totally 30 consecutive patients who had unilateral NAION and 30 gender-matched control subjects were recruited in the present *** diameter of ICAS of all the participants were measured using head-and-neck computed tomographic angiography(CTA).Color doppler flow imaging(CDI)was used to measure the haemodynamics parameters of ICAS and short posterior ciliary arteries(SPCAs)in all *** of parameters between the NAION patients and controls as well as between the two sides within the patients were *** correlation between the diameter of ICAS and NAION was ***:A comparison of parameters between the affected side of the NAION patients and the controls,including the diameter of ICAS,the resistance index(RI)of ICAS,the blood flow velocities of SPCAs and RI of SPCAs,showed significantly difference(P<0.01),while there was no significant difference in terms of the mean blood flow velocity(Vm)of ICAS;Similar results were found while comparing all the measurements of the affected and unaffected side of patients(P for RI of SPCAs<0.05).No marked difference was detected in nearly all parameters except for RI of ICAS and SPCAs between the unaffected side of the NAION patients and the controls(P<0.05).The diameter of ICAS were significantly positive correlated with both peak systolic velocity(PSV)of SPCAs and end diastolic velocity(EDV)of SPCAs in patients with NAION(r=0.514,P<0.01 and r=0.418,P<0.05,respectively).CONCLUSION:Narrowing of ICAS may increase the risk of developing NAION.

关键词： internal carotid artery siphon imageology haemodynamics parameter non-arteritic anterior ischaemic optic neuropathy

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